Morphogenesis and Complexity of the Tumor Patterns

On the relationship between aging & cancer

“…As emphasized in the introduction, a thermodynamical systems viewpoint may be useful for theory testing, since the adequacy of a postulated mechanism of aging is best judged by its compatibility with senescent changes. 10 Moreover, in previous works, 19 we have shown how the thermodynamic formalism, allows to evaluate the evolution, robustness and complexity of cancer.…”

“…This network of malignant cells could be considered as a nonlinear dynamical system, self-organized in time and space, far from thermodynamic equilibrium, exhibiting high complexity, robustness and adaptability. 19 In general, biological systems can be considered as complex dynamical systems that are self-organized far from the thermodynamical equilibrium. Complexity and diversity of these systems are the main features that have lead to find a multi-factor theory for aging.…”

What Can Be Learned from A Phase Transitions in Tumor Growth?

“…Tumor cell robustness enables a system to maintain its functionality in the face of various external and internal perturbations [4]. Tumor cells exhibit two aspects of robustness: functional redundancy, which appears in cellular heterogeneity, and feedback-control systems [4].…”

What Can Be Learned from A Phase Transitions in Tumor Growth?

“…In such a sense, in a previous work [4] we presented a conceptual definition of the cancer, such as: Cancer is a generic name given to a complex network of interactions of malignant cells, which have lost their specialization and control over normal growth. This network of malignant cells could be considered as a nonlinear dynamical system, self-organized in time and space, far from thermodynamic equilibrium, exhibiting high complexity [5], robustness [6] and adaptability [7].…”