Morphogenesis of the eggshells in Drosophila

Waring, Gail L.

doi:10.1016/s0074-7696(00)98003-3

Cited by 95 publications

(99 citation statements)

References 62 publications

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“…In dipteran insects, the characterized VMPs are proline, serine, glycine and alanine rich [8]. They possess an N-terminal hydrophobic region believed to act as a signal peptide and contain a highly conserved 38 AA hydrophobic core domain (VM domain) towards the C-terminus [32].…”

Section: Discussionmentioning

confidence: 99%

“…In null mutants for the VMP sV23, no e¡ects on the integrity of the follicle were reported [7,8] although the mutant eggs developed collapsed eggshells that were infertile [36]. These observations indicate that a functional VM is not required in Drosophila for maintaining the structure of the follicle but rather that it provides an initial sca¡old for chorion assembly and micropyle formation for fertilization.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to vertebrates in which the VM is secreted by the oocyte [7], in insects such as Drosophila and Bombyx, VM proteins (VMPs) are synthesized by and secreted from the cells of the follicular epithelium [1,8]. In the silkworm, the secretion of electron dense material at the follicular cell^oo-cyte interface at day 3 of pharate-adult development marks the initial stage of VM formation [2].…”

Section: Introductionmentioning

confidence: 99%

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An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

2002

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We have cloned and functionally characterized a novel protein, BmVMP30, which is synthesized by the cells of the follicular epithelium of the ovarian follicles of the domesticated silkworm Bombyx mori, secreted from them and associated with the vitelline membrane. BmVMP30 is a 30 kDa protein that bears limited structural features reminiscent of other insect vitelline membrane proteins. Although BmVMP30 does not share pronounced similarities or signature motifs with other reported proteins, its temporal and spatial expression and its behavior throughout oogenesis suggest that it is a novel member of the insect vitelline membrane protein family. The protein is expressed exclusively in the cells of the follicular epithelium during stages 3 315 to 3 31 of vitellogenesis, secreted from them and, ultimately, localized at the junction between the oocyte and the eggshell, where the vitelline membrane is located. Treatment of follicles with an antisense oligonucleotide that encompasses the translation initiation codon results in the production of an N-terminally truncated protein and disruption of the integrity of the follicular epithelium. Antisense oligonucleotide treatment, however, has no e¡ect on the implementation of the developmental program that directs the autonomous progression of ovarian follicles through the last stages of vitellogenesis and choriogenesis. ß

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

2002

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“…The Drosophila eggshell is a specialized extracellular matrix that is composed of the innermost VM, a wax layer, and an outmost chorion layer (reviewed in Waring, 2000). Drosophila eggs do not contain CGs, perhaps because sperm entry only occurs through a specialized opening in the chorion called the micropyle.…”

Section: Other Modifications To Egg Coveringsmentioning

confidence: 99%

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

Horner

Wolfner

2008

Developmental Dynamics

183

177

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The transition from mature oocyte to developing embryo requires a coordinated series of events, collectively known as egg activation. Egg activation includes changes to egg coverings to prevent polyspermy, release of oocyte meiotic arrest, generation of haploid female and male pronuclei, changes in maternal mRNAs and protein populations, and cytoskeletal rearrangements. In many animals, egg activation is triggered by fertilization, which increases intracellular calcium within the oocyte and thereby regulates molecular events of egg activation. In other animals, fertilization-independent external signals, including mechanical stimulation of eggs and/or changes in ionic milieu, trigger activation. Recent studies have clarified the upstream portion of pathways leading to eggshell changes and cell cycle resumption and have identified activation-induced changes in maternal mRNA and protein profiles that can identify molecular players in the downstream events of egg activation. We review signals that trigger activation and how they link to subsequent molecular events of egg activation. Developmental Dynamics 237:527-544, 2008.

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“…The Drosophila eggshell is an extracellular structure functional to the different roles it absolves, from egg fertilization to the hatching of the larva at the end of embryogenesis (Margaritis, 1985;Margaritis and Mazzini, 1998;Waring, 2000). This framework is laid down during late oogenesis between the oocyte and overlying follicle cells.…”

Section: Eggshell Morphologymentioning

confidence: 99%

Building up the Drosophila eggshell: First of all the eggshell genes must be transcribed

Cavaliere

Bernardi

Romani

et al. 2008

Developmental Dynamics

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The Drosophila eggshell provides a model system for studying the assembly of extracellular matrix. Eggshell formation is a complex process that requires time-coordinated synthesis, cleavage, and transport of various proteins and finally cross-linking mediated by particular functional domains. It has been suggested that the eggshell can act as a storage site for spatial cues involved in embryonic pattern formation. Its structural components are synthesized in the somatic follicle cells in a precise temporally and spatially regulated manner. This review will summarize our knowledge of eggshell gene expression. We will discuss the amplification of the chorion gene clusters and the data acquired on the expression patterns and the regulatory elements controlling transcription of eggshell genes. We will then focus on the findings that correlate follicular epithelium patterning and eggshell gene expression, and discuss the interesting perspectives of an involvement in eggshell assembly of embryonic patterning cues. Developmental Dynamics 237:2061-2072, 2008.

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Morphogenesis of the eggshells in Drosophila

Cited by 95 publications

References 62 publications

An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

Building up the Drosophila eggshell: First of all the eggshell genes must be transcribed

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