Morphological alteration of the eccrine sweat apparatus in amputated feet and legs of patients with diabetes mellitus

Mikiko, Sugiyama; Suzuki, Y.; Nakada, Tokio; Nemoto, Hitoshi; Suzuki, Hiroshi; Nagata, Shigeki; Sueki, Hirohiko

doi:10.1016/j.jdermsci.2016.08.117

Cited by 3 publications

(3 citation statements)

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“…17 Skin samples in limbs amputated for diabetic foot disease showed shrunken eccrine sweat glands with thickening of the basement membrane. 18 Patients with absent sweating have dry feet and the skin is at risk of cracking and infection. Advise an appropriate moisturising cream and extra vigilance by the patient and the diabetes team.…”

Section: Reduced Sweatingmentioning

confidence: 99%

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

et al. 2017

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Section: Reduced Sweatingmentioning

confidence: 99%

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

et al. 2017

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“…Although diabetes is commonly cited as a condition that contributes to secondary HH, some literature suggests that distally, persons with diabetes actually sweat less than controls. [21][22][23]…”

Section: Pathophysiology Of Sweating Within a Prosthesismentioning

confidence: 99%

Hyperhidrosis of the residual limb: a narrative review of the measurement and treatment of excess perspiration affecting individuals with amputation

Lannan

Powell

Kim

et al. 2021

Prosthetics &Amp; Orthotics International

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Background: Hyperhidrosis (HH) is a relatively common disorder involving excessive sweating, typically of the palms or axilla. HH can also frequently occur after limb amputation, where the remaining residual limb excessively perspires, leading to an increased risk of dermatological disorders and functional limitations, such as the inability to comfortably or safely wear a prosthesis. Although many treatments have been proposed to treat HH within the dermatology community, they are not widely known by healthcare providers typically involved in caring for individuals with acquired limb loss. Objectives: To appraise the current state of quantitative and qualitative assessment of HH within the residual limb and examine existing and future treatment strategies for this problem. Study design: Narrative Literature Review. Methods: A literature review focused on the assessment and treatment of excessive sweating of residual limbs. Results: There is currently no objective or subjective standard to assess or diagnose HH of the residual limb. Conventional therapies for HH do not always translate to the population of individuals with limb loss. Emerging modalities for treating HH show promise toward a permanent resolution of excess perspiration but require additional studies within people with amputation.Conclusions: Further research is needed to quantify standard values to objectively and subjectively assess and diagnose hyperhidrosis of the residual limb. New and developing treatments for hyperhidrosis require additional studies to assess efficacy and safety in the residual limb.

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“…Patients with sudomotor denervation also had evidence of cardiac autonomic neuropathy . Skin samples in limbs amputated for diabetic foot disease showed shrunken eccrine sweat glands with thickening of the basement membrane . Patients with absent sweating have dry feet and the skin is at risk of cracking and infection.…”

Section: Reduced Sweatingmentioning

confidence: 99%

Sweating in diabetes

Hillson¹

2017

Practical Diabetes

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Morphological alteration of the eccrine sweat apparatus in amputated feet and legs of patients with diabetes mellitus

Cited by 3 publications

References 0 publications

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Hyperhidrosis of the residual limb: a narrative review of the measurement and treatment of excess perspiration affecting individuals with amputation

Sweating in diabetes

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