Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms

Yamamoto, Shuichi; Yamamoto, Tohru; Hayashi, Masanori; Takeuchi, Shinobu

doi:10.1007/s004170000238

Cited by 113 publications

(81 citation statements)

References 16 publications

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“…Although there are reports evaluating central macular function in subjects with diabetic macular oedema using microperimetry with scanning laser ophthalmoscope, 23 fundus-related microperimeter 24 and multifocal ERG, 25 correlation of decreased retinal sensitivity as a corollary to reduced retinal thickness (in participants with no clinical diabetic retinopathy or maculopathy), as measured on spectral domain OCT and MP has not been reported earlier.…”

Section: Discussionmentioning

confidence: 95%

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

Verma

Rani

Raman

et al. 2009

Eye

146

118

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Purpose To elucidate changes in the neurosensory retina in the macular area, using spectral domain OCT and correlate with functional loss on fundus-related microperimetry, in patients with diabetes and no diabetic retinopathy compared with age-matched healthy volunteers. Methods This was a prospective study enroling 39 patients in each group. All patients underwent comprehensive dilated eye examination. The foveal thickness and the photoreceptor layer thickness at the foveal centre were measured using spectral domain OCT, and the mean retinal sensitivity of central 20 degrees was measured using microperimetry. Results The mean age of the patients with diabetes was 50.92 ± 4.75 years, and of controls, 49.87±5.50 years. SD-OCT measured photoreceptor layer thickness (PLT) to be 61.62±4.48 lm in cases, and 68.79±7.84 lm in controls (Po0.0001); foveal thickness (FT) was 168.64 ± 16.46 lm in cases and 177.74 ± 14.58 lm in controls (P ¼ 0.012). The mean retinal sensitivity (MRS) of the central 20 degrees, measured on microperimetry was 15.74±3.74 db in cases and 17.70±1.5 db in controls (Po0.003). In cases compared with controls (aged under 50 years) statistically significant differences were noted in all the three outcome variables: FT, P ¼ 0.030; PLT, P ¼ 0.015; and MRS, P ¼ 0.020. The duration of diabetes influenced only the PLT (P ¼ 0.017). Statistical analysis was performed with Student's t-test and v 2 test. Conclusion Neuronal damage was observed in those eyes that did not have clinical evidence of diabetic retinopathy.

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Section: Discussionmentioning

confidence: 95%

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

Verma

Rani

Raman

et al. 2009

Eye

146

118

View full text Add to dashboard Cite

show abstract

“…79,107,178,179,319 Foveal thickness as measured on optical coherence tomography (OCT) was found to be significantly correlated with mfERG amplitudes and implicit times. 178,319 Retinal locations with CSME had significant delays in mfERG implicit times with reduction in response amplitude. 79 The changes in implicit times were found to be more diffuse compared with amplitude changes and extended to areas without clinically manifesting macular edema.…”

Section: Diabetic Retinopathymentioning

confidence: 96%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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“…Similar findings were observed in two other studies on DMO patients who had undergone vitrectomy with the creation of a posterior vitreous detachment. 11,12 We assessed the macular function by multifocal electroretinography (mfERG) and found that the electrical responses obtained from the macular area were also significantly correlated with the FT. 11 In that electrophysiological study, we examined the macular mfERG from the central 10 degrees along with the VA and OCT-determined FT. Although the VA improved significantly and the FT was reduced significantly at 6 months postoperatively, the amplitude of the mfERGs did not show any significant change, and only the peak latency of the macular response decreased significantly.…”

mentioning

confidence: 99%

Functional and morphological changes of macula after subthreshold micropulse diode laser photocoagulation for diabetic macular oedema

Nakamura

Mitamura

Ogata

et al. 2009

Eye

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Purpose To examine the early changes of retinal sensitivity by fundus-related microperimetry after subthreshold micropulse diode laser photocoagulation (SMDLP) for diabetic macular oedema (DMO). Methods Twenty-eight eyes of 28 patients with diffuse DMO were treated with SMDLP. The mean retinal sensitivity within the central 10 degrees measured with a fundus-related microperimeter, MP1, best corrected visual acuity (BCVA) in logarithm of minimum angle of resolution units, and optical coherence tomography-determined foveal thickness (FT) were examined before and 3 months after SMDLP. The pretreatment values of the retinal sensitivity, FT, BCVA, and funduscopic findings were compared with the corresponding values at 3 months after SMDLP. Results At 3 months, the BCVA was significantly improved (P ¼ 0.03), and the FT was significantly reduced (P ¼ 0.0043). The mean retinal sensitivity within the central 10 degree, however, did not change significantly (P ¼ 0.70). The correlation between the changes in the retinal sensitivities and the decrease in the FT was not significant. The correlation between the changes in the retinal sensitivities and the BCVA was also not significant. Conclusions Significant improvements in retinal sensitivities within the central 10 degrees were not observed even though the decrease in FT and the improvement of BCVA were significant. On account of this difference of changes in retinal sensitivity and BCVA, the combination of retinal sensitivity by MP1 and BCVA may be beneficial in assessing the visual function from various angles after SMDLP for eyes with DMO.

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Morphological and functional analyses of diabetic macular edema by optical coherence tomography and multifocal electroretinograms

Abstract: The visual acuity was correlated significantly with morphological changes revealed by OCT and with multifocal ERGs. The combination of OCT and multifocal ERGs may provide objective criteria for the evaluation and assessment of diabetic macular edema.

Cited by 113 publications

References 16 publications

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Functional and morphological changes of macula after subthreshold micropulse diode laser photocoagulation for diabetic macular oedema

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