Morphological changes in endometrium of hemodialyzed women of reproductive age

Skórzewska, Katarzyna; Radowicki, Stanisław; Matuszkiewicz‐Rowińska, Joanna; Szlendak-Sauer, Katarzyna

doi:10.1080/09513590701557523

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Fourteen studies (18,23,24,27,29,33,(35)(36)(37)(38)(39)(40)(41)(42)(43) reported hormone therapy/contraceptive use, although numerous (15,34,(44)(45)(46)(47) considered hormone therapy as exclusion criteria. Eight dialysis-specific articles (24,(39)(40)(41)(42)(43)48) reporting on 585 individuals reported low use of hormone replacement therapy (n5363), oral contraceptives (n56), and intrauterine devices (n52) among study participants.…”

Section: Hormonal Therapy Usementioning

confidence: 99%

Menstrual Abnormalities and Reproductive Lifespan in Females with CKD

Rytz

Kochaksaraei

Skeith

et al. 2022

CJASN

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Background and objectivesMenstrual abnormalities and shortened reproductive lifespan are associated with shorter life expectancy and higher cardiovascular and osteoporosis risk in the general population, although the magnitude of these reproductive factor irregularities in females with CKD is unclear. This systematic review and meta-analysis aimed to summarize the current knowledge regarding menstrual abnormalities and reproductive lifespan among females with CKD.Design, setting, participants, & measurementsA comprehensive bibliographic search (MEDLINE, Embase, and Cumulative Index to Nursing and Allied Health Literature [CINAHL]) was completed from database inception to February 2022 to identify all original articles reporting on females of reproductive age with nondialysis-dependent/nonkidney transplant CKD, dialysis-dependent CKD, or kidney transplantation and menstruation patterns, age of menarche, and/or menopause. Data extraction and study quality assessment were completed in duplicate. Random effects meta-analyses were used to derive pooled proportions estimates.ResultsForty-six studies were identified, and 35 were meta-analyzed, stratified by KRT modality and reported outcome. Menstrual abnormalities were present in 19%–47% of patients on hemodialysis and 75% of patients on peritoneal dialysis. Kidney transplantation was associated with a 7%–30% decrease in menstrual abnormalities. Reproductive lifespan was 32 years (95% confidence interval, 30 to 34 years). Although significant heterogeneity was present, study quality ranged from fair to good, and no evidence of publication bias was noted.ConclusionsMenstrual abnormalities and shorter reproductive lifespan are common in females with CKD, although kidney transplantation may improve menstrual health.

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Section: Hormonal Therapy Usementioning

confidence: 99%

Menstrual Abnormalities and Reproductive Lifespan in Females with CKD

Rytz

Kochaksaraei

Skeith

et al. 2022

CJASN

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“…In addition, endometrial atrophy due to changes in the hypothalamic-pituitary-gonadal axis is common in predialyitic and hemodialysis female patients cause a disrupted ovulation process. Even if the menstrual cycle is regular, implantation impairment may occur due to changes in the pulsatility of hypothalamic-pituitary-gonadal hormones [6,7].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy and its outcomes in hemodialysis patients in Turkey

Dheir¹,

Güngör²,

Ulu³

et al. 2021

Turk J Med Sci

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Pregnancy and its outcomes in hemodialysis patients in TurkeyBackground/aim: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. Materials and methods:Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. Results:In this study, we reached 9038 HD female patients' data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 ± 7.4) years. The mean age at first gestation was 30.8 ± 6.5 years. The average birth week was 32 (28 -36) weeks. 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients' increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). Conclusion:For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that; increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates.

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