Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study)

Славнов, А. А.; Долгих, В. Т.

doi:10.15360/1813-9779-2014-4-37-43

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…The area of the profile of arterioles, capillaries, venules, their walls and lumen was measured. In arterioles and capillaries, the Vogenvort index (iV) was determined according to the formula [7]. Computer data processing was performed using the statistical package STATISTICA (StatSoft, Inc. (2010), STATISTICA (data analysis software system), version 10.…”

Section: Methodsmentioning

confidence: 99%

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Zhurakivska¹,

Koshkin²,

Tkachuk³

et al. 2020

PEP

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One of the complications of diabetes mellitus (DM) is diabetic myopathy, which is diagnosed in 88% of patients. Therefore, the purpose of our study was to establish the age characteristics of histo-ultrastructural changes in the masticatory muscle of 2-month (immature) and 6-month (mature) rats with streptozotocin-induced diabetes mellitus (STD). It was induced by a single intraperitoneal injection of streptozotocin 7 mg/100 g body weight in 2-month animals, and 6 mg/100 g body weight in 6-month-old rats. It was found that on the 70th day of STD there was a muscle sequestration and focal aseptic inflammatory cell infiltrates in the masticatory muscle of 2-month-old rats, while in 6-month-old animals the fibrosis and focal lysis of individual muscle fibers (MF), sometimes their necrosis and partial replacement by connective tissue were noticed. Sonography revealed in 6-month-old rats partial necrosis of MF, karyorexis, subsarcolemic edema, fibrosis and lysis of myofibrils, destruction of mitochondria; 2-month animals had intracellular regenerative processes: formation of young mitochondria, appearance of numerous granules of glycogen in the sarcoplasm between myofibrils. Such changes occur against the background of the diabetic microangiopathy. Adult animals had a massive destruction of neuromuscular junctions (NMJs) and it leads to a decrease in the area of axon sprouting by 67% and is accompanied by partial destruction of neuromuscular synapses. In 2-month-old rats, there was also a decrease in the area of NMJs by 54%, while in some NMJs the reinnervation processes were noted due to collaterals from neighboring nerve fibers. Thus, diabetic myopathy is diagnosed in the masticatory muscle of SDM rats of different ages, which results from the development of diabetic microangiopathy and peripheral neuropathy. In adult animals, it leads to atrophy and partial sclerosis of MF of the masticatory muscle, and in immature animals, compensatory-restorative processes are observed in the NMJs and MF.

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Section: Methodsmentioning

confidence: 99%

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Zhurakivska¹,

Koshkin²,

Tkachuk³

et al. 2020

PEP

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“…Histological sections were stained with hematoxylin and eosin, as well as Van Gieson-Weigert stain. The quantitative assessment of vascular reactions was performed by calculating the Wogenwort index (WI), which represents the ratio of the arterial wall area to its lumen area [16]. The functional state of cardiomyocytes was evaluated based on the nuclear-cytoplasmic ratios (NCR) in the left ventricular myocardium [15].…”

Section: Methodsmentioning

confidence: 99%

Quantitative characteristics of structural changes in the myocardium of white rats during the modeling of adrenaline myocardiodystrophy and its pharmacological correction

Herasymyuk

2023

Rep. of Morph.

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Pathology of the cardiovascular system is one of the leading causes of mortality and disability. In anesthesiology practice, it is the most common comorbid condition that leads to perioperative complications and fatal outcomes. The aim of the study was to substantiate the cardioprotective properties of succinic acid, sodium oxybutyrate, and quercetin based on the study of the myocardial morphological structure in the correction of experimental cardiac pathology. The experiments were conducted on white rats, in which adrenaline-induced myocardial dystrophy was modeled. The correction was performed using succinic acid, sodium oxybutyrate, and quercetin. Morphological studies were conducted at 2 and 24 hours after correction. At 2 hours after adrenaline administration, pronounced venous and arterial congestion was observed in the myocardium. The lumen of vessels appeared dilated, and their walls appeared thinner. In animals that received corrective agents after adrenaline, a positive effect of their application was noted. Vascular congestion was significantly reduced. The arterial walls had normal thickness, and the internal elastic membranes were moderately tortuous. No significant changes were observed in cardiomyocytes. At 24 hours from the start of pathology modeling and its pharmacological correction, the changes in the myocardium of the animals were much more pronounced compared to those with a 2-hour exposure, although in animals treated with corrective agents, the changes were less pronounced than in untreated animals. Rats exposed only to adrenaline showed significant trophic disturbances in cardiomyocytes, which developed against the background of coronary circulation disorders, manifested as wall thickening and narrowing of arterial lumens. The veins were congested, and blood extravasation was observed in the interstitium. Perivascular spaces expanded due to edema. Cardiomyocytes exhibited dystrophic changes, including areas with clarified cytoplasm, often with its homogenization and karyolysis. Histological data were morphometrically confirmed by changes in the Wogenworth index and nuclear-cytoplasmic ratios. The obtained results indicate the positive effect of the used corrective agents. Quercetin demonstrated slightly higher efficacy in this regard.

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“…The vascular wall is an integral functional structure that undergoes remodeling in response to hemodynamic changes in various physiological and pathological conditions [32]. Thus, the literature describes the morphological changes in the aortic wall [17,30], the femoral artery [13], the arterial bed of the lower limb [37,12], coronary [33], carotid [2,14,18,21], renal arteries [3] in the development of various pathological conditions.…”

Section: Factors Influencing Inflammationmentioning

confidence: 99%

“…Hypertrophy of the middle tunic of the abdominal part of ther aorta due to thickening of the smooth muscle layers testifies to the processes of remodeling in the vascular wall, which after massive blood loss is accompanied by a decrease in the number of elastic membranes and the expression of collagencontaining structures. For the thoracic part of the aorta, such changes are manifested by a decrease in the area of the middle membrane, a significant thickening of adventitia, and a sharp decrease in the coefficients of throughput ability, which may be an compensatory mechanism that allows effective blood supply of the brain and lungs in the long terms after massive blood loss [30].…”

Section: Factors Influencing Inflammationmentioning

confidence: 99%

Morphofunctional Peculiarities of Endocardium of the Ventricles, Main Arteries Normally and Under the Influence of Various Factors (Literature Review)

Sobol

Popadynets

2019

Galician med. j.

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The article analyzes the data of literary sources about the histological and ultramicroscopic structure of the endocardium of the ventricles and arteries of various types and caliber normally, as well as under the influence of various endo- and exogenous factors. The data on changes in the structure of the endocardium and major arteries in diabetes mellitus, atherosclerosis, ischemia, hypoxia, infectious endocarditis, poisoning with heavy-density metal salts, and also in hypothyroidism, which has recently been considered as one of the main factors in the development of complications in the cardiovascular system.

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Morphological Changes in the Aortic Wall after Blood Loss (An experimental Study)

Cited by 4 publications

References 3 publications

Untitled

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Quantitative characteristics of structural changes in the myocardium of white rats during the modeling of adrenaline myocardiodystrophy and its pharmacological correction

Morphofunctional Peculiarities of Endocardium of the Ventricles, Main Arteries Normally and Under the Influence of Various Factors (Literature Review)

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