Morphological Changes of the Cellularity in the Prostatic Gland from Patients with Confirmed Cancer: Gleason Level and Presence of Eosinophils and Mast Cells: Cellular Bioindicators

Rodríguez, Héctor; Cortés-Chau, Felipe; Cortés-Pino, Felipe; Aguirre, Pablo; Bravo, Gonzalo; Gallegos, Iván; Arriaza, Camilo; Cuellar, Caroll; Aguayo, Francisco; Espinoza-Navarro, Omar

doi:10.4067/s0717-95022020000400882

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Additionally, biochemical and physical dynamic signals are elements integrated into cellular behavior and tissue function, whose alterations participate in the development of prostatic disease, generating an imbalance between synthesis and degradation, leading to disease, injury, and aging (Rodríguez et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…However, age is one of the most determining factors, with treatment even varying according to the stage of progression and degree of the disease and the patient's age. Moreover, the degree of cancer progression is defined according to histological morphometric analysis (biopsy), where the degree of tissue differentiation is estimated (Manaia et al, 2012;Pin et al, 2013;Rodríguez et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Humoral and Cellular Immunology in Human Prostate Cancer: Plasma Cells and T and B Lymphocytes

Rodríguez,

Gallegos

et al. 2023

Int. J. Morphol.

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In solid and malignant tumors, innate and adaptive immunity are combined in antitumor responses. This study aimed to analyze the activation of plasma cells and the correlation between the infiltration of B and T lymphocytes with the degree of malignancy or Gleason grade in human prostate biopsies diagnosed with cancer. Prostate cancer biopsies were obtained from the Clinical Hospital of Universidad de Chile (n=70), according to the bioethical norms of the institution. Histological sections of 5µm thickness were processed for immunohistochemistry with primary antibodies against BL and total TL (HRP/DAB). Recognition and quantification were performed under a Leica DM750 optical microscope. Microsoft Excel and GraphPad software were used for the statistical study. Correlation coefficient (Pearson) and mean comparison tests (Kruskal-Wallis and Dunn) and p≤ 0.05 were developed. B and T lymphocyte populations were inversely interregulated in prostate cancer (Gleason) (r= -0.46). Their relationship with Gleason grade is variable according to lymphocyte type (LB vs. Gleason r= -0.0.47 and LT vs. Gleason r= -0.21). Histological diagnosis of prostate cancer correlates with a predominance of LT. The malignancy of the pathology correlates with a predominance of LTs, according to the Gleason grade. The increased knowledge of B and T lymphocyte infiltration and plasma cell activation could be used to better target clinical trials on treatments based on immune system responses. Immunotherapy could be a new paradigm to apply better antitumor therapy strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Humoral and Cellular Immunology in Human Prostate Cancer: Plasma Cells and T and B Lymphocytes

Rodríguez,

Gallegos

et al. 2023

Int. J. Morphol.

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“…MCs are multifunctional immune cells widely distributed throughout the body but preferentially present in the pulmonary system (Kilinç & Kilinç, 2020;Rodríguez et al, 2020). There are two main types of mast cells: connective tissue type (CTMC) and mucosal type (MMC).…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Mast Cells as Biological Markers in the Pathogenesis of Infectious Diseases and their Projection in Health Emergencies

Rodríguez-Bustos,

Espinoza-Navarro,

Arriaza

et al. 2024

Int. J. Morphol.

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Mast cells (MC) are cells of the immune system that regulate cell and tissue homeostasis, are found in low numbers, have an intact plasma membrane, and a cytoplasm with a wide variety of inflammatory chemical mediators. The activation or degranulation of mast cells implies the release of these chemical mediators (interleukins, cytokines, and more), causing tissue actions ranging from the activation of metalloproteinases to the development of anaphylactic hypersensitivity of different degrees, alterations in vascular permeability, and loss of cell homeostasis. This behavior would allow them to act as sentinels responding to pathophysiological processes. During the COVID-19 pandemic, in positive human patients, the available literature reports the presence and degranulation of mast cells in a generalized manner, especially in the respiratory tract. This study aimed to analyze the emerging role of MCs in the pathogenesis of diseases and their projection as biological markers in the treatment of diseases or pandemics. The analysis of human biopsies showed that MCs are observed as cells with diameters between 8 to 20 µm, and in inflamed tissues, degranulation of MCs is observed. The action of MCs degranulation was related to different inflammatory processes of autoimmune diseases. It is concluded that the potential of MC as therapeutic targets and biomarkers could raise new pharmacological targets, as supportive therapy, and possibly of great help in the treatment of future emerging pandemics such as the current monkeypox.

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Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

Fernandes,

Costa,

Fernandes

et al. 2023

Biomedicines

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Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis. However, the mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects the diagnosis methods for PCa and the pathophysiological mechanisms underlying the disease, clarifying the dynamic interplay between inflammation and leukocytes in promoting tumour development and spread. It provides updates on recent advances in elucidating and treating prostate carcinogenesis, and opens new insights for the use of bioactive compounds in PCa. Polyphenols, with their noteworthy antioxidant and anti-inflammatory properties, along with their synergistic potential when combined with conventional treatments, offer promising prospects for innovative therapeutic strategies. Evidence from the use of polyphenols and polyphenol-based nanoparticles in PCa revealed their positive effects in controlling tumour growth, proliferation, and metastasis. By consolidating the diverse features of PCa research, this review aims to contribute to increased understanding of the disease and stimulate further research into the role of polyphenols and polyphenol-based nanoparticles in its management.

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Morphological Changes of the Cellularity in the Prostatic Gland from Patients with Confirmed Cancer: Gleason Level and Presence of Eosinophils and Mast Cells: Cellular Bioindicators

Cited by 3 publications

References 24 publications

Humoral and Cellular Immunology in Human Prostate Cancer: Plasma Cells and T and B Lymphocytes

Humoral and Cellular Immunology in Human Prostate Cancer: Plasma Cells and T and B Lymphocytes

Emerging Role of Mast Cells as Biological Markers in the Pathogenesis of Infectious Diseases and their Projection in Health Emergencies

Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

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