Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine

Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine

“…Recently published data on the frequency of PTC with the dominant solid structure in Japanese patients aged ≤20 years at surgery [13] demonstrate that it is not meaningfully or significantly different from that in our study (8/81 cases, 10% vs. 27/160 cases, 16.9 %, respectively, p=0.177). Results obtained in this work taken together with those of the previous study of adult PTC patients [4] suggest that iodine deficiency in Ukraine may influence the frequency of PTC with the solid growth pattern in adults, but not in children or adolescents separately.…”

“…The reported earlier higher frequency of the solid component in childhood PTC from Ukraine, Belarus and Russia [6], and in PTC of adult patients from Ukraine without radiation history [4] was considered the major structural difference between Japanese and Ukrainian PTC. This difference has been proposed to be due to iodine deficiency in the areas around Chernobyl, including Ukraine.…”

“…3 Adjusted for age and sex. 4 ND, not determined. vascular invasion (OR=0.253, p=0.010) and regional lymph node metastases (OR=0.342, p=0.023) were observed.…”

“…Our previous work reported differences in tumor structure and invasive properties between Japanese and Ukrainian sporadic papillary thyroid carcinoma (PTC) in adult patients [4]. The Japanese PTC was characterized by a higher frequency of papillary architecture and invasive features such as extrathyroidal extension and regional lymph node metastases.…”

“…No distant metastases to the bone, the brain or other sites were detected. Tumor staging was according to the 7th edition of TNM classification system [8], which assigns minimal extrathyroidal extension pT3 category [4,9].…”