Morphological findings in bone marrow biopsy and aspirate smears of visceral kala azar: A review

Dhingra, Kajal Kiran; Gupta, Parul; Saroha, Vijay; Setia, Namrata; Khurana, Nita; Singh, Tejinder

doi:10.4103/0377-4929.59193

Cited by 30 publications

(25 citation statements)

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“…Kalazar is one of the cause of pancytopenia and frequency is very high in some studies done in india and Pakistan. 15 Visceral leishmaniasis is endemic in some parts of india and may simulate and cause many hematological disorders like pancytopenia, myelofibrosis, MDS and hemophagocytosis as mentioned by Sud et al 16 In this study one case of Gaucher disease was diagnosed in a 20 yrs female. Study of Ahmad et al showed that storage disorders were diagnosed in 2.4% cases of pancytopenia.…”

Section: Figure 6: Acute Myeloblastic Leukemia Myeloblasts With Finementioning

confidence: 99%

Evaluation of bone marrow in patients with pancytopenia

2012

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Background: Pancytopenia is a common hematological finding resulting from varieties of disease processes that require evaluation of bone marrow. This study was carried out to evaluate bone marrow findings in patients presenting with pancytopenia. Materials and Method:This was a prospective cross sectional study carried out to identify the causes of pancytopenia based on bone marrow examination. Bone marrow examinations were performed in 503 cases for different indications over a period of one year. Results:One hundred and two (20.27%) cases fulfilled the criteria of pancytopenia. Trephine biopsy was possible only in 48 cases. In 75% cases aspiration findings were similar to biopsy. Mean age of patients was 38.8 years. Maximum number of cases was seen in age group of 15-30 years. Hypoplastic anemia was the commonest cause followed by hematological malignancies, megaloblastic anemia, leishmaniasis and Gaucher disease. Bone marrow examination alone was able to establish the diagnosis in 76.5% cases. In rest marrow findings were nonspecific and in 4.9% cases findings were normal. Conclusion:Bone marrow aspiration coupled with trephine biopsy can diagnose majority but not all the cases of pancytopenia. Hypoplastic anemia, hematological malignancies and megaloblastic anemia are the commonest causes of pancytopenia. Maximum diagnostic yield can be achieved by correlation with clinical findings, peripheral blood findings and with other laboratory and radiological parameters.

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Section: Figure 6: Acute Myeloblastic Leukemia Myeloblasts With Finementioning

confidence: 99%

Evaluation of bone marrow in patients with pancytopenia

2012

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“…In Ethiopia Visceral Leishmaniasis has been reported from at least 40 areas, with the most endemic areas are Metema and Humera lowlands of Northwest, which accounts for 60% of the total burden [17]. The disease is characterized by fever, hepatosplenomegaly, anemia, leucopenia and Thrombocytopenia [8].…”

Section: Statement Of the Problemmentioning

confidence: 99%

“…Hematological abnormalities are common complication of patients having Visceral Leishmaniasis since the disease is a chronic illness which is characterized by irregular fever, hepatosplenomegaly and panctyopenia, progressive weakness and emaction which can result to death if left untreated [8]. In addition, the spleen size and duration of illness correlate with some of the main hematological features [6].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the spleen size and duration of illness correlate with some of the main hematological features [6]. On the other hand; hematological system in the form of bone marrow and peripheral blood changes are seen in Visceral Leishmaniasis patients such as anemia (normochromic normocytic anemia), leucopenia (especially neutropenia) and thrombocytopenia are common abnormalities [6,8]. Granulocytic and megakaryocyte morphology has been reported to be unaltered except for an increase in immature forms in some cases [8].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand; hematological system in the form of bone marrow and peripheral blood changes are seen in Visceral Leishmaniasis patients such as anemia (normochromic normocytic anemia), leucopenia (especially neutropenia) and thrombocytopenia are common abnormalities [6,8]. Granulocytic and megakaryocyte morphology has been reported to be unaltered except for an increase in immature forms in some cases [8]. From Visceral Leishmaniasis related hematological abnormalities, anemia is the most common abnormalities [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study

Tesfaye¹

2017

IJHPEBS

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Abstract:Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.

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Inflammatory and Infectious Diseases

Beham‐Schmid

Schmitt‐Graeff

2020

Essentials of Diagnostic Pathology

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Morphological findings in bone marrow biopsy and aspirate smears of visceral kala azar: A review

Cited by 30 publications

References 2 publications

Evaluation of bone marrow in patients with pancytopenia

Evaluation of bone marrow in patients with pancytopenia

Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study

Inflammatory and Infectious Diseases

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Morphological findings in bone marrow biopsy and aspirate smears of visceral kala azar: A review

Cited by 30 publications

References 2 publications

Evaluation of bone marrow in patients with pancytopenia

Evaluation of bone marrow in patients with pancytopenia

Haematological Abnormalities in &lt;i&gt;Visceral Leishmaniasis&lt;/i&gt; Patients Attending Gondar University Hospital; Retrospective Study

Inflammatory and Infectious Diseases

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Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study