Morphological, immunophenotypic and clinical characteristics of dogs with lymphocytic - plasmacytic duodenitis

Abstract

The most important morphological feature of the immune response in lymphocytic-plasmacytic duodenitis (LPD) in dogs is the presence of a mononuclear infiltrate in the duodenal mucosa. The ethiopatogenesis of this disease is still unknown, nor are known all the immunophenotypic characteristics of the infiltrate cells, which would be of help in the elucidation of the pathogenesis of LPD. The study involved 60 adult dogs of different breeds and both sexes: 54 dogs with symptoms of diarrhea and vomiting that lasted longer than three weeks and six clinically healthy dogs that served as controls. Hematological and biochemical analysis of blood, radiology, ultrasound and endoscopic diagnosis were carried out. Samples of duodenal mucosal biopta were examined by histopathological and immunohistochemical methods. During endoscopic examination, duodenal wall thickening, mucosal edema and hyperemia were observed in 46 dogs. Microscopic studies showed on the epithelial cells of the duodenum degenerative changes, and sometimes desquamation. Most of the intestinal crypts were dilated, irregularly shaped and filled with detritus. On immunohistochemical examination of samples of the duodenum in a number of dogs with LPD a predominant expression of CD3 + T lymphocytes was observed. [Projekat Ministarstva nauke Republike Srbije, br. III 46002

Detection of Helicobacter-like organisms in dogs with chronic gastric and intestinal inflammation

“…Compared to that, only 7 dogs were diagnosed having lymphoplasmacytic and eosinophilic (LPE) inflammation, 6 of them with LPE enteritis and one dog with LPE colitis, which represents 6% and 2% of dogs that had their small intestine and colon examined, respectively. This is in agreement with other studies which also showed relatively low prevalence of LPE enteritis (5.6-8.7% of dogs with chronic GI signs) (Craven et al 2004;Lidbury et al 2009;Đorđević et al 2012;Volkmann et al 2017;Ivasovic et al 2022). As regards mixed inflammation, we detected only 5% of cases of enteritis being characterized by this type of inflammation, whereas Craven et al (2004) and Volkmann et al (2017) reported the prevalence of mixed intestinal inflammation to be 38% and 53%, respectively.…”

“…On the other hand, lacteal dilation was just as common or even more common in our group of samples (28% of cases of duodenitis and 43% of cases of ileitis) than in previously published studies (2.2-29.0% of cases of duodenitis and 38% of cases of ileitis) (Lidbury et al 2009;Đorđević et al 2012;Procoli et al 2013;Çolakoğlu et al 2017). We can conclude that both villous stunting and lacteal dilation were more frequent in ileum compared to duodenum which corresponds to the observation of Casamian-Sorrosal et al ( 2010) that morphological abnormalities are sometimes more readily detectable in ileal mucosa.…”

Result of Endoscopically Assisted Gastropexy in Dogs

“…An endoscopically assisted gastropexy successfully minimizes the number and size of surgical incisions. This theoretically should result in a decreased duration of anaesthesia, degree of postoperative pain and requirements for analgesia, incidence of incision complications, duration of hospitalization, and cost [3,25,26]. Additionally, this minimally invasive technique allows for a decrease in the amount of equipment necessary to perform the procedure, compared with that required for other currently used minimally invasive laparoscopically assisted gastropexy procedures [8,9,16,18].…”