Morphology and function of Bast’s valve: additional insight in its functioning using 3D-reconstruction

Hofman, Rutger; Segenhout, J. M.; Buytaert, Jan A.N.; Dirckx, Joris; Wit, H. P.

doi:10.1007/s00405-007-0424-8

Cited by 34 publications

(33 citation statements)

References 18 publications

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“…Merging of OPFOS and μCT data revealed shrinking of the soft and bony tissue, most likely caused by the elaborate OPFOS specimen preparation (e.g., tissue fixation, decalcification, dehydration, and Spalteholz treatment), though previous authors reported that this procedure induced negligible shrinking (Voie 2002;Valk et al 2005;Hofman et al 2008). Thanks to the combination of OPFOS with μCT, we have undeformed reference data that we can use to derive a scaling factor.…”

Section: Artifactsmentioning

confidence: 90%

Realistic 3D Computer Model of the Gerbil Middle Ear, Featuring Accurate Morphology of Bone and Soft Tissue Structures

Buytaert

Salih

Dierick

et al. 2011

JARO

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In order to improve realism in middle ear (ME) finiteelement modeling (FEM), comprehensive and precise morphological data are needed. To date, micro-scale X-ray computed tomography (μCT) recordings have been used as geometric input data for FEM models of the ME ossicles. Previously, attempts were made to obtain these data on ME soft tissue structures as well. However, due to low X-ray absorption of soft tissue, quality of these images is limited. Another popular approach is using histological sections as data for 3D models, delivering high in-plane resolution for the sections, but the technique is destructive in nature and registration of the sections is difficult. We combine data from high-resolution μCT recordings with data from high-resolution orthogonal-plane fluorescence opticalsectioning microscopy (OPFOS), both obtained on the same gerbil specimen. State-of-the-art μCT delivers high-resolution data on the 3D shape of ossicles and other ME bony structures, while the OPFOS setup generates data of unprecedented quality both on bone and soft tissue ME structures. Each of these techniques is tomographic and non-destructive and delivers sets of automatically aligned virtual sections. The datasets coming from different techniques need to be registered with respect to each other. By combining both datasets, we obtain a complete high-resolution morphological model of all functional components in the gerbil ME. The resulting 3D model can be readily imported in FEM software and is made freely available to the research community. In this paper, we discuss the methods used, present the resulting merged model, and discuss the morphological properties of the soft tissue structures, such as muscles and ligaments.

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Section: Artifactsmentioning

confidence: 90%

Realistic 3D Computer Model of the Gerbil Middle Ear, Featuring Accurate Morphology of Bone and Soft Tissue Structures

Buytaert

Salih

Dierick

et al. 2011

JARO

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“…1b). Opening of the valve would be hypothetically accomplished by pressure displacement of the outer membranous wall away from the more rigid inner valve lip (Anson and Wilson, 1929;Hofman et al, 2008). Because the human UEV was not confirmed here as well as in previous studies, the valve lip was not actually constructed, but was assumed to be incorporated into the membranous wall (Fig.…”

Section: Introductionmentioning

confidence: 84%

Numerical simulation of the role of the utriculo-endolymphatic valve in the rotation-sensing capabilities of semicircular canals

Shen

Sun

Shen

et al. 2016

Journal of Biomechanics

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“…A further narrow conjunction between different endolymphatic compartments of the inner ear is the utriculo-saccular duct [18]. The narrowest passage of the utricular duct has a diameter of 10 lm [19]. Although the exact function of Bast's valve (utriculo-endolymphatic valve) at the entrance of the utricular duct is not known, its architecture indicates a role in fluid volume regulation [19].…”

Section: Discussionmentioning

confidence: 99%

“…The narrowest passage of the utricular duct has a diameter of 10 lm [19]. Although the exact function of Bast's valve (utriculo-endolymphatic valve) at the entrance of the utricular duct is not known, its architecture indicates a role in fluid volume regulation [19]. Anatomically the endolymphatic system is a communicating entity, but its functional patency is not completely known.…”

Section: Discussionmentioning

confidence: 99%

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Hydrostatic fluid pressure in the vestibular organ of the guinea pig

Park

Boeven

Vogel

et al. 2011

Eur Arch Otorhinolaryngol

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Since inner ear hair cells are mechano-electric transducers the control of hydrostatic pressure in the inner ear is crucial. Most studies analyzing dynamics and regulation of inner ear hydrostatic pressure performed pressure measurements in the cochlea. The present study is the first one reporting about absolute hydrostatic pressure values in the labyrinth. Hydrostatic pressure of the endolymphatic system was recorded in all three semicircular canals. Mean pressure values were 4.06 cmH(2)O ± 0.61 in the posterior, 3.36 cmH(2)O ± 0.94 in the anterior and 3.85 cmH(2)O ± 1.38 in the lateral semicircular canal. Overall hydrostatic pressure in the vestibular organ was 3.76 cmH(2)O ± 0.36. Endolymphatic hydrostatic pressure in all three semicircular canals is the same (p = 0.310). With regard to known endolymphatic pressure values in the cochlea from past studies vestibular pressure values are comparable to cochlear values. Until now it is not known whether the reuniens duct and the Bast's valve which are the narrowest passages in the endolymphatic system are open or closed. Present data show that most likely the endolymphatic system is a functionally open entity.

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Morphology and function of Bast’s valve: additional insight in its functioning using 3D-reconstruction

Cited by 34 publications

References 18 publications

Realistic 3D Computer Model of the Gerbil Middle Ear, Featuring Accurate Morphology of Bone and Soft Tissue Structures

Realistic 3D Computer Model of the Gerbil Middle Ear, Featuring Accurate Morphology of Bone and Soft Tissue Structures

Numerical simulation of the role of the utriculo-endolymphatic valve in the rotation-sensing capabilities of semicircular canals

Hydrostatic fluid pressure in the vestibular organ of the guinea pig

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