Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights

Bertolini, Marcelo; Mason, Jeffrey B.; Beam, S. W.; Carneiro, Gustavo Ferrer; Sween, Matthew L; Kominek, Daniel J; Moyer, Alice L.; Famula, Thomas R.; Sainz, Roberto Daniel; Anderson, G. B.

doi:10.1016/s0093-691x(02)00935-4

Cited by 169 publications

(141 citation statements)

References 61 publications

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“…Reports on abnormal vascularization of the allantois during early pregnancy [14,44] and data on deviant cardiac structure and function in some foetal and newborn ruminants resulting from IVP embryos [27,52,60] require more studies on prenatal cardiovascular function. This is supported by the recent finding of Bertolini et al [6] that FHR of IVP-concepti (n = 6) was significantly higher between days 37 and 93 of gestation when compared with MOET (n = 6) foetuses. We therefore also included measurements of FHR in our study with three groups of bovine pregnancies [9,10].…”

Section: Moetsupporting

confidence: 77%

“…Especially the measurement of foetal body structures (CRL: crown rump length; BPD: biparietal diameter of the cranium; CAU: cross section of the abdomen) can be expected to reflect both the retardation or enhancement of foetal growth. Recently, Bertolini and coworkers [6] reported that the CRL of foetuses, derived from IVP-co-culture beef cattle embryos, had a significantly reduced CRL between days 37-58 when compared to foetuses from MOET embryos, while at birth the mean body weight of the IVP calves (n = 6) was significantly higher.…”

Section: Moetmentioning

confidence: 99%

“…However, reliable quantification of ultrasonographic details of the development of the conceptus is only possible at a later stage [6,13,23,33]. Especially the measurement of foetal body structures (CRL: crown rump length; BPD: biparietal diameter of the cranium; CAU: cross section of the abdomen) can be expected to reflect both the retardation or enhancement of foetal growth.…”

Section: Moetmentioning

confidence: 99%

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The monitoring of bovine pregnancies derived from transfer of in vitro produced embryos

et al. 2002

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-Both an increased rate of embryonic, foetal and perinatal losses, and the occurrence of deviations in foetal and placental development are associated with bovine pregnancies obtained from in vitro produced embryos. This thus requires for a more accurate and frequent monitoring of foetal and maternal functions during pregnancies. Such approaches will enable to establish the period during which these losses and deviations in development occur and to plan possible clinical interventions. This paper reviews some recent data on return rates, late embryonic and foetal losses in recipients after the transfer of either MOET, IVF or nuclear transfer embryos. Special attention is paid to the diagnostic value of measurements of pregnancy specific/associated proteins and progesterone in maternal plasma. Possibilities to measure foetal body sizes, size of placentomes and foetal heart rate by means of transrectal or transabdominal ultrasonography are illustrated with data from the literature and with recent results from our own large field study with MOET, IVP-co-culture and IVP-SOF embryos.cow / pregnancy / pregnancy proteins / ultrasonography / foetus / placenta / foetal heart rate / embryo transfer / in vitro fertilization / nuclear transfer Reprod. Nutr. Dev. 42 (2002) 613-624 613

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Section: Moetsupporting

confidence: 77%

Section: Moetmentioning

confidence: 99%

Section: Moetmentioning

confidence: 99%

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The monitoring of bovine pregnancies derived from transfer of in vitro produced embryos

et al. 2002

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“…In the present study, the number of cotyledons per placenta varied between 51 and 211, with only seven cows expelling fetal membranes having more than 150 cotyledons. These results are comparable to those of Bertolini et al (2002), who mentioned a range of 52 to 153 cotyledons counted on expelled fetal membranes of Angus and Angus × Hereford pregnancies. Within the BB breed, cows had 35 cotyledons less than heifers but the individual surface of their cotyledons was 4.5 cm 2 larger.…”

Section: Discussionsupporting

confidence: 88%

Evidence for placental compensation in cattle

Eetvelde

Kamal

Hostens

et al. 2016

Animal

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Prenatal development is known to be extremely sensitive to maternal and environmental challenges. In this study, we hypothesize that body growth and lactation during gestation in cattle reduce nutrient availability for the pregnant uterus, with consequences for placental development. Fetal membranes of 16 growing heifers and 27 fully grown cows of the Belgian Blue (BB) breed were compared to determine the effect of body growth on placental development. Furthermore, the fetal membranes of 49 lactating Holstein Friesian (HF) cows and 27 HF heifers were compared to study the impact of dam lactation compared to dam body growth. After parturition, calf birth weight and body measurements of dam and calf were recorded, as well as weight of total fetal membranes, cotyledons and intercotyledonary membranes. All cotyledons were individually measured to calculate both the surface of each individual cotyledon and the total cotyledonary surface per placenta. Total cotyledonary surface was unaffected by breed or the breed × parity interaction. Besides a 0.3 kg lower cotyledonary weight ( P = 0.007), heifer placentas had a smaller total cotyledonary surface compared with placentas of cows (0.48 ± 0.017 v. 0.54 ± 0.014 m 2 , respectively, P < 0.001). Within the BB breed, fetal membranes of heifers had a 1.5 kg lower total weight and 1.0 kg lower intercotyledonary membrane weight ( P < 0.005) compared with cows. A cotyledon number of only 91 ± 5.4 was found in multiparous BB dams, while growing BB heifers had a higher cotyledon number (126 ± 6.7, P < 0.001), but a greater proportion of smaller cotyledons (<40 cm 2 ). Within the HF breed, no parity effect on intercotyledonary membrane weight, cotyledon number and individual cotyledonary surface was found. Placental efficiency (calf weight/total cotyledonary surface) was similar in HF and BB heifers but significantly higher in multiparous BB compared with multiparous HF dams (106.0 ± 20.45 v. 74.3 ± 12.27 kg/m 2 , respectively, P < 0.001). Furthermore, a seasonal effect on placental development was found, with winter and spring placentas having smaller cotyledons than summer and fall placentas ( P < 0.001). Main findings of the present study are that lactation and maternal growth during gestation entail a comparable nutrient diverting constraint, which might alter placental development. However, results suggest that the placenta is able to manage this situation through two potential compensation mechanisms. In early pregnancy the placenta might cope by establishing a higher number of cotyledons, while in late gestation a compensatory expansion of the cotyledonary surface is suggested to meet the nutrient demand of the fetus.

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“…This aspect may contribute to the different gene transcription profiles observed between bovine embryos produced in vitro and in vivo (Wrenzycki et al, 2004). In IVF embryos, some genes are expressed at a low level, such as transcripts associated with compactation/cavitation (Wrenzycki et al, 1996), stress adaptation (Rizos et al, 2002), embryonic metabolism (Bertolini et al, 2002), and X chromosome inactivation (Wrenzycki et al, 2002). Therefore, bovine embryogenesis seems to be an appropriate model for studying histone modifications in human pre implantation development, including in vitro embryonic genome activation.…”

Section: In Vitro Production (Ivp) Of Mammalian Embryos: How Other Spmentioning

confidence: 99%

Analysis of Permissive and Repressive Chromatin Markers in In Vitro Fertilized Bovine Embryos Just After Embryonic Genome Activation

Oliveira¹,

Saraiva²,

Oliveira³

et al. 2012

In Vitro Fertilization - Innovative Clinical and Laboratory Aspects

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Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights

Cited by 169 publications

References 61 publications

The monitoring of bovine pregnancies derived from transfer of in vitro produced embryos

The monitoring of bovine pregnancies derived from transfer of in vitro produced embryos

Evidence for placental compensation in cattle

Analysis of Permissive and Repressive Chromatin Markers in In Vitro Fertilized Bovine Embryos Just After Embryonic Genome Activation

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