Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate

Keetch, David W.; Humphrey, Peter A.; Stahl, David; Smith, Deborah S.; Catàlona, William J.

doi:10.1016/s0022-5347(01)67044-7

Cited by 115 publications

(57 citation statements)

References 7 publications

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“…15,22 Thus, in a study of 65 radical prostatectomy specimens, high grade PIN was found not to contribute to elevated serum PSA 23 and other recent studies also suggest that PIN alone does not increase the serum PSA. 1,24 We observed similar serum PSA levels in men with benign histological ®ndings and those with high grade PIN, and higher levels in men with cancer.…”

Section: Discussionsupporting

confidence: 54%

Prevalence of prostatic intra-epithelial neoplasia (PIN) in biopsies from hospital practice and pilot screening: clinical implications

Feneley

Green

Young

et al. 1997

Prostate Cancer Prostatic Dis

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and 5 UCL Hospitals Trust and UCL, LondonAs high grade PIN is commonly associated with concomitant cancer, current literature recommends re-biopsy of patients with high grade PIN. This paper describes the prevalence of high grade prostatic intra-epithelial neoplasia (PIN) from three independent clinical settings, reported by a single pathologist (MCP). High grade PIN was diagnosed in biopsies from 131 of the 1205 (11%) of patients in whom cancer was suspected in hospital practice, 42 of the 202 (20%) asymptomatic men screened for prostate cancer and 29 of the 118 (25%) patients presenting with prostatism in a case ®nding study.Re-biopsy on this scale has major clinical and cost implications. However, from a literature review, there is evidence to suggest that the risk of concomitant cancer with high grade PIN may be strati®ed according to serum PSA. This opinion should be tested prospectively.

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Section: Discussionsupporting

confidence: 54%

Prevalence of prostatic intra-epithelial neoplasia (PIN) in biopsies from hospital practice and pilot screening: clinical implications

Feneley

Green

Young

et al. 1997

Prostate Cancer Prostatic Dis

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“…This indicates that the prostate cancer risk is increased with the increase in the number of specimens found to have HGPIN on the 1 st biopsy. Our result also agreed with that of Bostwick et al [2], Abdel-khalek et al [23] and Rosser et al [27], However, it disagreed with studies that revealed lower prostate detection rate (De Nunzio et al [22], Kamoi et al [28] and Epstein & Herawi [29]) and other studies with higher prostate detection rate (Keetch et al [30] and Borboroglu et al [25]). …”

Section: Discussionsupporting

confidence: 75%

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

Al-Dabbagh¹,

Mohammad²,

Jaffal³

2018

OJU

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Objective: To determine the consequence of recognizing high grade prostatic intraepithelial neoplasia (HGPIN) & its extent on initial sextant prostatic biopsy then identifying its associated risk of finding prostate cancer on subsequent biopsy. Patients and methods: Seventy-one men were subjected to transrectal ultrasound guided sextant prostate biopsy due to elevated serum prostate specific antigen (S.PSA) > 4 ng /ml, an abnormal digital rectal examination (DRE) and/or transrectal ultrasound (TRUS) findings. The number, percentage, as well as bilateral and multifocal involvement of specimens positive for HGPIN were recorded in every patient. The percentage of cancer detected in these patients on repeat biopsy within 1 year of the initial biopsy was also recorded. Results: The mean age and mean S.PSA level of our patients was 59.9 years and 7.9 ng/ml respectively. Of the 71 patients studied, initial biopsy revealed that (32.4%) had benign prostatic hyperplasia (BPH), (36.62%) had carcinoma, (25.35%) had HGPIN and (5.63%) had chronic prostatitis. On repeat biopsy within 1 year of initial biopsy cancer of the prostate was detected in 33.3% of our patients who were diagnosed with HGPIN on 1 st biopsy. All of them had multifocal involvement on the initial biopsy. Conclusion: Recognizing HGPIN on 1 st biopsy (particularly multifocal involvement) is associated with great risk of prostate cancer development on subsequent biopsy, thus comprehensive follow-up of these patients is necessary.

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“…Other series have also found a high predictive value of PIN for cancer, although recent reports based on obtaining a greater number of cores shows a lower predictive value (Table 4). 51,[54][55][56][150][151][152][153][154][155][156][157][158] These data underscore the strong association of PIN and adenocarcinoma and indicate that vigorous diagnostic follow up is needed.…”

Section: Men With Pin Develop Prostate Cancermentioning

confidence: 99%

High-grade prostatic intraepithelial neoplasia

2004

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High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be detected by current imaging techniques, including ultrasound. Most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

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Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate

Cited by 115 publications

References 7 publications

Prevalence of prostatic intra-epithelial neoplasia (PIN) in biopsies from hospital practice and pilot screening: clinical implications

Prevalence of prostatic intra-epithelial neoplasia (PIN) in biopsies from hospital practice and pilot screening: clinical implications

Is High Grade Prostatic Intraepithelial Neoplasia a Risk Factor for Prostate Cancer?—A Local Study

High-grade prostatic intraepithelial neoplasia

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