Morphometric analysis of coronary artery stenosis: An accuracy and reliability study

Manwarring, Lynette; O’Connell, Dianne; Bhagwandeen, S. B.; Zardawi, Ibrahim M.; Dobson, Annette

doi:10.1002/path.1711560205

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…This may be due to the fact that gross examination is only able to accurately assess stenosis when it is less than 30% or more than 70%. 7,16,29 The findings of this study support this since when the microscopic assessment was <75% there was the least correlation between the two methods.…”

Section: Discussionsupporting

confidence: 82%

Evaluation of coronary stenosis with the aid of quantitative image analysis in histological cross sections

Dulohery

Papavdi

Michalodimitrakis

et al. 2012

Journal of Forensic and Legal Medicine

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Section: Discussionsupporting

confidence: 82%

Evaluation of coronary stenosis with the aid of quantitative image analysis in histological cross sections

Dulohery

Papavdi

Michalodimitrakis

et al. 2012

Journal of Forensic and Legal Medicine

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“…Accuracy can be improved by a visual aid, similar to that in Fig. 1 [20]. Ideally, gross assessments should be confirmed by histology, taking the internal elastic lamina as the original lumen size.…”

Section: Stenosis Due To Stable (Not Thrombosed) Plaquesmentioning

confidence: 99%

Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification

et al. 2019

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Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and postmortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinicalpathological correlations with currently defined types of myocardial infarction.

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“…Measurements of intimal and medial cross-sectional areas (mm2) were made by a skilled observer blinded to the treatment groups. An eyepiece grid with 100 counting points (line intersections), each 0.4 mm apart, was used (25,26 …”

Section: Histomorphometrymentioning

confidence: 99%

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

Cooke¹,

Singer²,

Tsao³

et al. 1992

J. Clin. Invest.

661

267

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The purpose of this study was to determine if chronic administration of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF), normalizes endothelium-dependent relaxation and decreases atherosclerosis in hypercholesterolemic animals. Male rabbits were fed (a) normal rabbit chow; (b) 1% cholesterol diet; or (c) 1% cholesterol diet supplemented by 2.25% L-arginine HCI in drinking water. Arginine supplementation doubled plasma arginine levels without affecting serum cholesterol values. After 10 wk, the thoracic aorta was harvested for studies of vascular reactivity and histomorphometry.Endothelium-dependent relaxations (to acetylcholine and calcium ionophore A23187) were significantly impaired in thoracic aortae from animals fed a 1% cholesterol diet. By contrast, vessels from hypercholesterolemic animals receiving Larginine supplementation exhibited significantly improved endothelium-dependent relaxations. Responses to norepinephrine or nitroglycerin were not affected by either dietary intervention. Histomorphometric analysis revealed a reduction in lesion surface area and intimal thickness in thoracic aortae from arginine-supplemented animals compared to those from untreated hypercholesterolemic rabbits. This is the first study to demonstrate that supplementation of dietary L-arginine, the EDRF precursor, improves endothelium-dependent vasorelaxation. More importantly, we have shown that this improvement in EDRF activity is associated with a reduction in atherogenesis. (J. Clin. Invest. 1992.

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Morphometric analysis of coronary artery stenosis: An accuracy and reliability study

Cited by 16 publications

References 15 publications

Evaluation of coronary stenosis with the aid of quantitative image analysis in histological cross sections

Evaluation of coronary stenosis with the aid of quantitative image analysis in histological cross sections

Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

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