Morphometric Evaluation of Nb84, Synaptophysin and Agnor Is Useful for the Histological Diagnosis and Prognosis in Peripheral Neuroblastic Tumors (Pnts)

Carvalho, Aparecida de Cássia; Parra, Edwin Roger; Zerbini, Maria Cláudia Nogueira; Alves, Venâncio Avancini Ferreira; Capelozzi, Vera Luíza; Antonângelo, Leila

doi:10.1590/s1807-59322007000600013

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…In NB, immunostaining for CgA and syn are usually included in the routine histopathological diagnostics. Blood concentrations of CgA are also frequently elevated in patients with NB and CgA can thus be used as a circulating biomarker [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma

et al. 2019

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Neuroblastoma (NB), the most common extracranial cancer in childhood, exhibits neuroendocrine (NE) differentiation. Two well-established NE markers, chromogranin A (CgA) and synaptophysin (syn), are used in the histopathological diagnostics. Our aims were to explore if the NE markers synaptic vesicle protein 2 (SV2) and vesicular monoamine transporter 1 (VMAT1) and 2 (VMAT2) also are expressed in human NB and if so, evaluate their usefulness in NB histopathological diagnostics. Tumor specimens from 21 NB patients, before and/or after chemotherapy, were immunostained for CgA, syn, SV2, VMAT1, and VMAT2. Clinical data was extracted from patients' records. SV2 was highly expressed in NB, as was CgA while syn was less frequently expressed compared to the other two. Both VMATs were expressed in several NB, VMAT2 in more cases than VMAT1 and its expression was similar to syn. Chemotherapy did not affect the immunoreactivity in an obvious way. SV2 was highly expressed in NB and can thus be useful marker in NB diagnostics. VMAT1 and VMAT2 were also expressed in NB but similar to syn less reliable as tumor markers.

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Section: Introductionmentioning

confidence: 99%