Morphophysiological, proteomic and metabolomic analyses reveal cadmium tolerance mechanism in common wheat (Triticum aestivum L.)

Zhang, Dazhong; Li, Jiajia; Zhang, Yuanbo; Wang, Hairong; Wei, Shuwei; Zhang, Xu; Zhang, Ding; Ma, Haosen; Ding, Qin; Ma, Lingjian

doi:10.1016/j.jhazmat.2022.130499

Cited by 35 publications

(15 citation statements)

References 61 publications

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“…45 GSH is a substrate for GSTs and a precursor for PCs, playing a vital role in Cd detoxification. 46 Unlike a previous study where the GSH synthesis was significantly upregulated after Cd stress in wheat seedlings, 37 our study showed that GSH contents were significantly decreased after Cd exposure in both rice genotypes. These findings suggest that the depletion of GSH might contribute to the formation of GSH-Cd and PCs, and these substances could be sequestered in vacuoles for Cd detoxification in plant cells.…”

Section: ■ Discussioncontrasting

confidence: 98%

“…Alkaloids were reported to reduce free Cd 2+ by increasing pH in the root rhizosphere, thereby inhibiting Cd uptake in wheat. 37 These findings suggested that the increased agmatine in NH224 might enhance Cd tolerance in rice. Flavonoids can eliminate free radicals.…”

Section: ■ Discussionmentioning

confidence: 92%

“…This finding was also consistent with the accumulation of polyphenols (cinnamoyl tyramine, gentisic acid, and homovanillic acid) in the root of NH224, associated with more robust antioxidant systems. Alkaloids were reported to reduce free Cd 2+ by increasing pH in the root rhizosphere, thereby inhibiting Cd uptake in wheat . These findings suggested that the increased agmatine in NH224 might enhance Cd tolerance in rice.…”

Section: Discussionmentioning

confidence: 95%

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Comparative Metabolomics Combined with Physiological Analysis Revealed Cadmium Tolerance Mechanism in Indica Rice (Oryza sativa L.)

Chang

Wang

Shi

et al. 2023

J. Agric. Food Chem.

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Cadmium (Cd) pollution reduces rice production and quality, putting food security and human health at risk. We conducted comparative physiology and metabolomic analyses in two indica rice ('NH199' and 'NH224') to elucidate the Cdtolerance mechanism. Cd hampered rice growth, induced oxidative stress, and changed the metabolomics profiling of the root. The biochemical and physiological analysis demonstrated that NH224 exhibited a more potent Cd-tolerance ability than NH199. Cd was primarily distributed in root, and NH224 had a lower Cd translocation factor than NH199 by about 24%. The metabolomic analysis revealed 180 and 177 differentially accumulated metabolites between Cd-stressed seedlings and the controls in NH224 and NH199, respectively. In NH224, amino acids biosynthesis, hormone metabolism, lipids-related metabolism, phenylalanine metabolism, and phenylpropanoid biosynthesis pathways were more active and highly associated with antioxidant defense system, biosynthesis of the cell wall and phytochelatins, and maintenance of plasma membrane stability. These findings provide insights into the metabolic profiles of rice following Cd stress and the screening and breeding of Cd-tolerant rice varieties.

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Section: ■ Discussioncontrasting

confidence: 98%

Section: ■ Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 95%

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Comparative Metabolomics Combined with Physiological Analysis Revealed Cadmium Tolerance Mechanism in Indica Rice (Oryza sativa L.)

Chang

Wang

Shi

et al. 2023

J. Agric. Food Chem.

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“…Metabolomic data demonstrated the impact of Cd on lipid and amino acid metabolism, and the regulation of glutathione, α-linolenic acid metabolism, and phenylpropanoid biosynthesis pathways by Cd was shown by proteome data. Wheat growth, photosynthesis, and mineral nutrient absorption all decreased by Cd after it impacted the plant nitrogen metabolism, according to an association study of the metabolome and proteome . In cotton plants, the co-expression network analyses of proteins and phosphoprotein showed that mepiquat chloride (MC) treatment mitigates the adverse effects of salt stress by upregulating essential proteins and phosphorylation for triacylglycerol (TAG) mobilization, γ-aminobutyric acid (GABA) shunt, and adenosine triphosphate (ATP) synthesis .…”

Section: Discussionmentioning

confidence: 99%

“…Wheat growth, photosynthesis, and mineral nutrient absorption all decreased by Cd after it impacted the plant nitrogen metabolism, according to an association study of the metabolome and proteome. 51 In cotton plants, the co-expression network analyses of proteins and phosphoprotein showed that mepiquat chloride (MC) treatment mitigates the adverse effects of salt stress by upregulating essential proteins and phosphorylation for triacylglycerol (TAG) mobilization, γ-aminobutyric acid (GABA) shunt, and adenosine triphosphate (ATP) synthesis. 52 Current studies showed that silicon might regulate aquaporin, amino acid biosynthesis, and starch and sugar metabolism and could alleviate the damaging effects of oxidation using transcriptome, proteome, and metabolome analyses.…”

Section: ■ Discussionmentioning

confidence: 99%

Multiomics Explore the Detoxification Mechanism of Nanoselenium and Melatonin on Bensulfuron Methyl in Wheat Plants

Zhou,

Miao,

Dong

et al. 2024

J. Agric. Food Chem.

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Combining nanoselenium (nano-Se) and melatonin (MT) was more effective than treatment alone against abiotic stress. However, their combined application mitigated the toxic effects of bensulfuron methyl, and enhanced wheat growth and metabolism has not been studied. Metabolomics and proteomics revealed that combining nano-Se and MT markedly activated phenylpropanoid biosynthesis pathways, elevating the flavonoid (quercetin by 33.5 and 39.8%) and phenolic acid (vanillic acid by 38.8 and 48.7%) levels in leaves and roots of wheat plants. Interstingly, beneficial rhizosphere bacteria in their combination increased (Oxalobacteraceae, Nocardioidaceae, and Xanthomonadaceae), which positively correlated with the enhancement of soil urease and fluorescein diacetate enzyme activity (27.0 and 26.9%) and the allelopathic substance levels. To summarize, nano-Se and MT mitigate the adverse effects of bensulfuron methyl by facilitating interactions between the phenylpropane metabolism of the plant and the beneficial microbial community. The findings provide a theoretical basis for using nano-Se and MT to remediate herbicidecontaminated soil.

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Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity

Raza,

Salehi,

Bashir

et al. 2024

Plant Cell Rep

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The escalating challenges posed by metal(loid) toxicity in agricultural ecosystems, exacerbated by rapid climate change and anthropogenic pressures, demand urgent attention. Soil contamination is a critical issue because it significantly impacts crop productivity. The widespread threat of metal(loid) toxicity can jeopardize global food security due to contaminated food supplies and pose environmental risks, contributing to soil and water pollution and thus impacting the whole ecosystem. In this context, plants have evolved complex mechanisms to combat metal(loid) stress. Amid the array of innovative approaches, omics, notably transcriptomics, proteomics, and metabolomics, have emerged as transformative tools, shedding light on the genes, proteins, and key metabolites involved in metal(loid) stress responses and tolerance mechanisms. These identified candidates hold promise for developing high-yielding crops with desirable agronomic traits. Computational biology tools like bioinformatics, biological databases, and analytical pipelines support these omics approaches by harnessing diverse information and facilitating the mapping of genotype-to-phenotype relationships under stress conditions. This review explores: (1) the multifaceted strategies that plants use to adapt to metal(loid) toxicity in their environment; (2) the latest findings in metal(loid)-mediated transcriptomics, proteomics, and metabolomics studies across various plant species; (3) the integration of omics data with artificial intelligence and high-throughput phenotyping; (4) the latest bioinformatics databases, tools and pipelines for single and/or multi-omics data integration; (5) the latest insights into stress adaptations and tolerance mechanisms for future outlooks; and (6) the capacity of omics advances for creating sustainable and resilient crop plants that can thrive in metal(loid)-contaminated environments.

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Morphophysiological, proteomic and metabolomic analyses reveal cadmium tolerance mechanism in common wheat (Triticum aestivum L.)

Cited by 35 publications

References 61 publications

Comparative Metabolomics Combined with Physiological Analysis Revealed Cadmium Tolerance Mechanism in Indica Rice (Oryza sativa L.)

Comparative Metabolomics Combined with Physiological Analysis Revealed Cadmium Tolerance Mechanism in Indica Rice (Oryza sativa L.)

Multiomics Explore the Detoxification Mechanism of Nanoselenium and Melatonin on Bensulfuron Methyl in Wheat Plants

Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity

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