Morris water maze learning in Long-Evans rats is differentially affected by blockade of D1-like and D2-like dopamine receptors

Stuchlı́k, Aleš; Řeháková, Lenka; Telenský, Petr; Valeš, Karel

doi:10.1016/j.neulet.2007.06.012

Cited by 46 publications

(25 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dopamine modulates these effects through two types of G-protein-coupled receptors: the D1- and D2-like receptor, respectively [20]. A large number of studies demonstrated that the D1 dopamine receptor D1DR in the hippocampus is critical for learning and memory [21,22,23]. Dopamine receptors affect neuronal function mainly via regulation of the cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, which includes activation of the protein kinase A (PKA) as well as phosphorylation in the cAMP response element-binding protein (CREB) [24].…”

Section: Introductionmentioning

confidence: 99%

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats

et al. 2018

IJMS

View full text Add to dashboard Cite

Atrazine (ATR) is a widely used herbicide that has been implicated as a neurotoxicant. Recent experimental evidence has implicated that ATR exposure also appears to have adverse effects on the hippocampus, which is a critical region for learning and memory. The aim of the present study was to investigate the effects of ATR toxicity on the hippocampus of developing rats. Postnatal day (PND) 28 male Sprague–Dawley (SD) rats received ATR by oral gavage at 10 or 100 mg/kg bodyweight (BW) for 30 consecutive days and were sacrificed at PND 90. Behavioral test results indicated that spatial learning and memory were affected by ATR treatment. Electron microscopy analysis showed that the ultrastructures of the hippocampus were altered in the ATR-treated groups, as compared to the control group. Additionally, ATR treatment impacted dopamine and D1 dopamine receptor (D1DR) contents through different mechanisms. Reduced mRNA and protein expression levels of factors involved in the cAMP-dependent signaling pathway were also detected. These results indicate that the developmental exposure of rats to ATR can damage the hippocampus and spatial memory, which might be related to the downregulation of expression levels of the D1DR and its downstream signaling pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…The Carousel maze apparatus was described in detail in our previous study (Stuchlik et al, 2007, 2013). Briefly, it consisted of a smooth metallic circular arena (82 cm in diameter), enclosed with a 30-cm high transparent Plexiglas wall and elevated 1 m above the floor of a 4 m × 5 m room.…”

Section: Methodsmentioning

confidence: 99%

“…Spatial navigation as a behavioral manifestation of knowledge of the environment (i.e., cognitive map; Tolman, 1948) is considered as a useful and experimentally well-accessible animal analogy of declarative memory (O’Keefe and Nadel, 1978; Eichenbaum, 2001; Morris, 2013). Testing of spatial navigation requires sensitive spatial paradigms, such as the MWM (Morris, 1981; Morris et al, 1982; Stuchlik et al, 2007). This test can be used in many configurations, allowing testing of reference and working memory acquisition, consolidation, and retrieval.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Psilocin on Memory Acquisition, Retrieval, and Consolidation in the Rat

Rambousek

Páleníček²,

Valeš

et al. 2014

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

The involvement of the serotonin system in the pathophysiology of schizophrenia has been elucidated by experiments with hallucinogens. Application of a hallucinogen to humans leads to changes in perception, cognition, emotions, and induction of psychotic-like symptoms that resemble symptoms of schizophrenia. In rodent studies, their acute administration affects sensorimotor gating, locomotor activity, social behavior, and cognition including working memory, the phenotypes are considered as an animal model of schizophrenia. The complexity and singularity of human cognition raises questions about the validity of animal models utilizing agonists of 5-HT2A receptors. The present study thus investigated the effect of psilocin on memory acquisition, reinforced retrieval, and memory consolidation in rats. Psilocin is a main metabolite of psilocybin acting as an agonist at 5-HT2A receptors with a contribution of 5-HT2C and 5-HT1A receptors. First, we tested the effect of psilocin on the acquisition of a Carousel maze, a spatial task requiring navigation using distal cues, attention, and cognitive coordination. Psilocin significantly impaired the acquisition of the Carousel maze at both doses (1 and 4 mg/kg). The higher dose of psilocin blocked the learning processes even in an additional session when the rats received only saline. Next, we examined the effect of psilocin on reinforced retrieval and consolidation in the Morris water maze (MWM). The dose of 4 mg/kg disrupted reinforced retrieval in the MWM. However, the application of a lower dose was without any significant effect. Finally, neither the low nor high dose of psilocin injected post-training caused a deficit in memory consolidation in the MWM. Taken together, the psilocin dose dependently impaired the acquisition of the Carousel maze and reinforced retrieval in MWM; however, it had no effect on memory consolidation.

show abstract

“…8, 10 or 12. The learning in this task is incremental, and healthy animals of the Long-Evans strain from the breeding colony of the Institute of Physiology, AS CR usually reach the asymptote escape latency by the fourth daily session (with 8 swims; Stuchlik et al, 2004;Vales et al, 2006;Stuchlik et al, 2007a). An early study by Morris showed that place navigation in this version is impaired by a hippocampal lesion.…”

Section: Morris Water Maze (Mwm)mentioning

confidence: 99%

Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders

Stuchlı́k¹,

Petrásek²,

Hatalova³

et al. 2012

Schizophrenia in the 21st Century

Self Cite

View full text Add to dashboard Cite

Morris water maze learning in Long-Evans rats is differentially affected by blockade of D1-like and D2-like dopamine receptors

Cited by 46 publications

References 19 publications

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats

The Effect of Psilocin on Memory Acquisition, Retrieval, and Consolidation in the Rat

Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders

Contact Info

Product

Resources

About