Mortality and causes of death of Dutch burn patients during the period 2006–2011

Dokter, J.; Felix, Miriam; Krijnen, Pieta; Vloemans, Jos F. P. M.; Baar, Margriet E. van; Tuinebreijer, W.E.; Breederveld, R.S.

doi:10.1016/j.burns.2014.10.009

Cited by 40 publications

(59 citation statements)

References 23 publications

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“…Sepsis is one of the common causes of death in intensive care units [26–28]. The pathogenesis of sepsis involves invading pathogens, host immune responses, and multiple tissue damage caused by their complex interactions.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Chen

Liu

et al. 2019

BioMed Research International

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Sepsis is a critical, complex medical condition, and the major causative pathogens of sepsis are both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Genome-wide studies identify differentially expressed genes for sepsis. However, the results for the identification of DEGs are inconsistent or discrepant among different studies because of heterogeneity of specimen sources, various data processing methods, or different backgrounds of the samples. To identify potential transcriptional biomarkers that are differently expressed in S. aureus- and E. coli-induced sepsis, we have analyzed four microarray datasets from GEO database and integrated results with bioinformatics tools. 42 and 54 DEGs were identified in both S. aureus and E. coli samples from any three different arrays, respectively. Hierarchical clustering revealed dramatic differences between control and sepsis samples. GO functional annotations suggested that DEGs in the S. aureus group were mainly involved in the responses of both defense and immune regulation, but DEGs in the E. coli group were mainly related to the regulation of endopeptidase activity involved in the apoptotic signaling pathway. Although KEGG showed inflammatory bowel disease in the E. coli group, the KEGG pathway analysis showed that these DEGs were mainly involved in the tumor necrosis factor signaling pathway, fructose metabolism, and mannose metabolism in both S. aureus- and E. coli-induced sepsis. Eight common genes were identified between sepsis patients with either S. aureus or E. coli infection and controls in this study. All the candidate genes were further validated to be differentially expressed by an ex-vivo human blood model, and the relative expression of these genes was performed by qPCR. The qPCR results suggest that GK and PFKFB3 might contribute to the progression of S. aureus-induced sepsis, and CEACAM1, TNFAIP6, PSTPIP2, SOCS3, and IL18RAP might be closely linked with E. coli-induced sepsis. These results provide new viewpoints for the pathogenesis of both sepsis and pathogen identification.

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Section: Discussionmentioning

confidence: 99%

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Chen

Liu

et al. 2019

BioMed Research International

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“…Anuria/oliguria progressed to kidney failure in 28 patients. Among the 3 primary complications associated with death in burn patients, acute renal failure is commonly observed, and is associated with multiple organ failure 6 .…”

Section: Discussionmentioning

confidence: 99%

“…However, many patients with severe burns develop complications that require complex multidisciplinary treatment, and many die 3,4 . Among the most common complications, sepsis and pneumonia often progress to multiple organ failure, which is s a major cause of mortality in these patients [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic profiles, major complications, and mortality rate at a burn treatment center in the Amazon

Silva¹,

Vendramin²,

Martins³

et al. 2018

Revista Brasileira De Cirurgia Plástica (RBCP) – Brazilian Journal of Plastic Sugery

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Introduction: Despite complex multidisciplinary treatment, many burn patients die. This study aimed to determine epidemiologic profiles of burn patients, highlighting major complications. Methods: This retrospective study analyzed the medical records of burn patients managed at the Metropolitan Hospital for Urgent and Emergent Care, Pará State, between January 2007 and December 2012. Results: most patients were males (69.1%) aged 18 to 30 years (35.5%), referred from other hospitals (35.8%), and employed as construction workers (21.2%). The most frequent complications were respiratory (69.4%) and renal failure (57.1%), followed by sepsis (38.8%). Conclusions: The data obtained were similar to those reported in national and international literature, highlighting the need for burn prevention and inspection of construction sites, as well as implementation of treatment protocols to improve care for burn patients.

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“…Infection and organ damage after burn are the main causes of death of burn patients. [ 1 , 2 ] Burns are the fourth most common traumatic injury in the human body, with an estimated 11 million people around the world seeking treatment for burns every year. [ 3 , 4 ] Compared with mild to moderate burns,severe burns are more likely to leave scars, which may not only cause some dysfunction, but also seriously affect the image of patients, cause psychological burden and reduce the quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of platelet-rich plasma in the treatment of severe burns

Chen

Turxun

et al. 2020

Medicine

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Background: In recent years, platelet-rich plasma (PRP) has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. Clinical studies indicate that PRP has a good curative effect on repairing burn wounds. The residual wounds formed after large area severe burns are difficult to cure and have recurrent attacks. Because the action mechanism of PRP is unclear, its clinical efficacy of PRP in repairing severe burn wounds is controversial. And there is no relevant systematic evaluation of PRP in repairing severe burn wounds now. Objective: Meta analysis was used to evaluate the efficacy and safety of PRP in repairing severe burn wounds. Methods: Randomized controlled clinical trial of using PRP to repair severe burn wounds were retrieved by computer WanFang, China National Knowledge Infrastructure, China Science and Technology Journal Database, China Biology Medicine disc, Embase, PubMed, Web of Science and Cochrane Library from the establishment of the database to September 2020. Two researchers independently extract data and assess the quality of the included literature, and Meta analysis of the included literature is carried out by using RevMan5.3 software. Results: In this study, the efficacy and safety of PRP in repairing severe burn wounds are evaluated from the aspects of wound healing rate, wound healing time, scar index, visual simulation score, the number of layers of dressing, the number of times of changing gauze, frequency of dressing change, the positive rate of wound bacterial culture and the incidence of inflammatory reaction. Conclusions: PRP has a good curative effect on the repair of severe burn wounds. This study provides reliable evidence for the clinical use of PRP in the clinical repair of severe burn wounds. OSF Registration number: DOI 10.17605/OSF.IO/FG682

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Mortality and causes of death of Dutch burn patients during the period 2006–2011

Cited by 40 publications

References 23 publications

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Epidemiologic profiles, major complications, and mortality rate at a burn treatment center in the Amazon

Efficacy and safety of platelet-rich plasma in the treatment of severe burns

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