Mortality from circulatory system diseases and low-level radon exposure in the French cohort study of uranium miners, 1946–1999

Nusinovici, Simon; Vacquier, Blandine; Leuraud, Klervi; Metz-Flamant, Camille; Caër-Lorho, Sylvaine; Acker, A.; Laurier, Dominique

doi:10.5271/sjweh.2896

Cited by 27 publications

(17 citation statements)

References 46 publications

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“…In models with two terms for RDP exposures and γ-ray doses, risks were due to γ-ray doses only, and the fit of the model did not improve with addition of the RDP exposures term ( p=0.70). While some studies of uranium miners reported no association between RDP exposures and CVD mortality, 16 29 30 a recent study suggested that increased risks might be due to slowly soluble uranium. 31 Significant positive associations between γ-ray doses and increased risks of CVD mortality were reported in relation to low-dose (ERR/ Sv=0.10, 95% CI 0.04 to 0.15) 17 and moderate-dose radiation exposures (ERR/Sv=0.14, 95% CI 0.06 to 0.23).…”

Section: Discussionmentioning

confidence: 97%

“…14 Based on the literature review, 8 15 we paid special attention to several outcomes that have been shown to be associated with exposures to radium and uranium processing, including cancers of the lung and bronchi, leukaemia and lymphoma, bone, liver and kidney cancers, as well as non-malignant respiratory, renal and liver diseases. We also investigated possible associations with CVD outcomes based on recent reports of increased risks from low-dose RDP 16 and γ-ray exposures, 17 in uranium miners and nuclear workers, respectively.…”

Section: Materials and Methods Cohort Characteristics And Follow-upmentioning

confidence: 99%

“…The summary person-year experience was crossclassified by age at risk (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), …, 85-100 years), calendar-year at risk (1950-1954, 1955-1959, …, 1995-1999 for mortality and 1969-1974, …, 1995-1999 for incidence follow-up), total duration of employment (<6 months and 6 months+), ii and age at first exposure, cumulative exposure, and years since first exposure, separately for RDP exposures and γ-ray doses. The person-year-weighted mean cumulative exposure in each cross-classified cell was used in the regression analysis.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Mortality (1950–1999) and cancer incidence (1969–1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses

Zablotska

Lane

Frost³

2013

BMJ Open

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ObjectivesUranium processing workers are exposed to uranium and radium compounds from the ore dust and to γ-ray radiation, but less to radon decay products (RDP), typical of the uranium miners. We examined the risks of these exposures in a cohort of workers from Port Hope radium and uranium refinery and processing plant.DesignA retrospective cohort study with carefully documented exposures, which allowed separation of those with primary exposures to radium and uranium.SettingsPort Hope, Ontario, Canada, uranium processors with no mining experience.Participants3000 male and female workers first employed (1932–1980) and followed for mortality (1950–1999) and cancer incidence (1969–1999).Outcome measuresCohort mortality and incidence were compared with the general Canadian population. Poisson regression was used to evaluate the association between cumulative RDP exposures and γ-ray doses and causes of death and cancers potentially related to radium and uranium processing.ResultsOverall, workers had lower mortality and cancer incidence compared with the general Canadian population. In analyses restricted to men (n=2645), the person-year weighted mean cumulative RDP exposure was 15.9 working level months (WLM) and the mean cumulative whole-body γ-ray dose was 134.4 millisieverts. We observed small, non-statistically significant increases in radiation risks of mortality and incidence of lung cancer due to RDP exposures (excess relative risks/100 WLM=0.21, 95% CI <−0.45 to 1.59 and 0.77, 95% CI <−0.19 to 3.39, respectively), with similar risks for those exposed to radium and uranium. All other causes of death and cancer incidence were not significantly associated with RDP exposures or γ-ray doses or a combination of both.ConclusionsIn one of the largest cohort studies of workers exposed to radium, uranium and γ-ray doses, no significant radiation-associated risks were observed for any cancer site or cause of death. Continued follow-up and pooling with other cohorts of workers exposed to by-products of radium and uranium processing could provide valuable insight into occupational risks and suspected differences in risk with uranium miners.

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Section: Discussionmentioning

confidence: 97%

Section: Materials and Methods Cohort Characteristics And Follow-upmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

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Mortality (1950–1999) and cancer incidence (1969–1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses

Zablotska

Lane

Frost³

2013

BMJ Open

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“…Moreover, CSD increasing risk was also observed among plutonium workers6–8 and uranium miners 42. However, many other factors, biological (eg, heredity), physiological (eg, hypertension, diabetes) and lifestyle related (eg, physical activity, smoking) are known to cause CSD, according to complex mechanisms with lots of interactions.…”

Section: Discussionmentioning

confidence: 99%

Does uranium induce circulatory diseases? First results from a French cohort of uranium workers

et al. 2012

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The authors observed that exposure to slowly soluble uranium, namely RPU, may increase the risk of CSD mortality. However, these results are preliminary since the study is lacking statistical power and many other biological and lifestyle-related factors may cause CSD. More detailed investigations are necessary to confirm these findings and analyse in depth the effects of internal radiation exposure on the circulatory system.

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“…The International Agency for Research on Cancer classifies radon as a human carcinogen 26 because of evidence of an association between radon and lung cancer summarized in the BEIR VI report. 27 Recent studies have suggested that other health outcomes such as leukemia 28,29 and cardiovascular disease 30,31 may also be linked to radon exposure, although results are equivocal. The average cumulative radon exposure estimated for the FMPC cohort (26 WLMs) is comparable to exposures (i.e., within a factor of 3) in some uranium miner studies reporting excess lung cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Exposure assessment for a cohort of workers at a former uranium processing facility

Anderson

Daniels

Fleming

et al. 2012

J Expo Sci Environ Epidemiol

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Mortality from circulatory system diseases and low-level radon exposure in the French cohort study of uranium miners, 1946–1999

Cited by 27 publications

References 46 publications

Mortality (1950–1999) and cancer incidence (1969–1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses

Mortality (1950–1999) and cancer incidence (1969–1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses

Does uranium induce circulatory diseases? First results from a French cohort of uranium workers

Exposure assessment for a cohort of workers at a former uranium processing facility

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