Mortality study of British pathologists

Hall, Andrew J.; Harrington, J M; Aw, Tar-Ćhing

doi:10.1002/ajim.4700200108

Cited by 66 publications

(45 citation statements)

References 5 publications

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“…The fact that an association was also not observed among subgroups defined by sex, smoking level, or histological subtype further supports formaldehyde not being associated with lung cancer risk. Our null results among women are consistent with those reported in the only three studies presenting results separately for women (13,16,20), among which there was no evidence of an association. To our knowledge, our female case series represents the largest used to study formaldehyde to date and the one with the greatest proportion of exposed women (35.5%).…”

Section: Discussionsupporting

confidence: 82%

“…However, these errors significant (6,9), one among women only (13). In two smaller cohorts of health professionals, statistically significant inverse associations (standardized mortality ratios) were reported (8,16). Both studies included few exposed cases and used information from professional associations to assign formaldehyde exposure according to health profession.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, few studies had information on exposure to other occupational lung carcinogens that may be correlated with formaldehyde exposure (2,6,11,22,28). In addition, only six studies (2,13,16,20,21,29) included women in their study population, though analyses by gender were reported in only three studies (13,16,20).…”

mentioning

confidence: 99%

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Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case–control studies

Mahboubi

Koushik²,

Siemiatycki³

et al. 2013

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case–control studies

Mahboubi

Koushik²,

Siemiatycki³

et al. 2013

Scand J Work Environ Health

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“…Cohorts of such workers have been studied in the United States (2)(3)(4)(5)(6)(7)(8), in the United Kingdom (9)(10)(11)(12), Sweden (l3), Italy (14), and Ireland (15). The most recent studies show that the overall mortality caused by cancer among these workers is lower than among the general population.…”

mentioning

confidence: 99%

Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (I), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158-1144], as was the number of brain cancer cases (SMR 239, 95% CI 48-696). Among the men, mortality from bone cancer was greater than expected (SMR 553,95% CI 62-2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5-331 and microbial genetics (OR 6.7, 95% CI 1.3-35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). C O~~C~U S~O~~S As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested casereferent study.

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“…Cardiovascular death was chosen because of the established link between work-related stress and death from cardiovascular causes. 5,18,20,21 Brain neoplasm was chosen because of its implication in excess mortality in pathologists, 17 its link with viral infection, 25 and anecdotal reports of patient-tosurgeon transmission of malignant tumor. 15 Leukemia and other hematopoietic neoplasms were chosen because of the frequent use of fluoroscopy in the operating room and the increased incidence of these neoplasms in radiologists during the early 20th century.…”

mentioning

confidence: 99%

Cause-specific mortality among neurosurgeons

Lollis

Valdés

Li³

et al. 2010

JNS

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Object The authors sought to determine a cause-specific mortality profile for US neurosurgeons during the period 1979–2005. Methods Neurosurgeons who died during the study period were identified from the Physician Master File database. Using the National Death Index, the reported cause of death was identified for 93.7% of decedents. Standardized mortality ratios were used to compare mortality risk in the study cohort to that of the US population. Results There was a marked reduction in mortality from virtually all causes in comparison with the control population. This finding is consistent with prior studies of mortality in physicians. The small number of deaths among female neurosurgeons precluded meaningful analysis for this group. Increased mortality risk for male neurosurgeons was seen from leukemia, nervous system disease (particularly Alzheimer disease), and aircraft accidents. Deaths from viral hepatitis and HIV infection, considered to be occupational hazards for surgeons, were less frequent than in the general population. Suicide, drug-related deaths, and alcohol-related deaths were less frequent than in the general population. Conclusions Neurosurgeons may be at higher risk for death from leukemia, aircraft accidents, and diseases of the nervous system, particularly Alzheimer disease; however, the mortality profile of neurosurgeons is favorable when compared with the general population.

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Mortality study of British pathologists

Cited by 66 publications

References 5 publications

Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case–control studies

Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case–control studies

Cancer risk among workers in biomedical research

Cause-specific mortality among neurosurgeons

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