Mortality Study of Talc Miners and Millers

Rubino, Giovanni; Scansetti, G; Piolatto, G; Romano, Canzio

doi:10.1097/00043764-197603000-00013

Cited by 84 publications

(62 citation statements)

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“…Of the 16 samples, tremolite was found in two (designated: I5, "General Ore"; 141, "Face 2") but only using optical microcopy, not by TEM or XRD. Wagner, Berry, Hill, Skidmore, & Pooley, (1979) and Rubino, Scansetti, Piolatto, & Romano (1976) also reviewed the work of Lightfoot et al (1972) and concluded there was no evidence of asbestos in the talc from the Fontane mine.…”

Section: Studies Of Talc Orementioning

confidence: 99%

“…(Parmeggiani, 1948;Scansetti, Rasetti & Ghemi (1963), Rubino, Maranzana, Pettinati, & Scansetti, (1963), Rubino et al (1976), Rubino, Scansetti, Piolatto, & Gay (1979); Coggiola et al, (2003), Pira et al, 2017;Pira, pers comm. (2017); also see additional commentary supportive of the lack of attendant cancer risk by Wild (2006), Baan et al (2006) andIARC (2010).…”

Section: Epidemiological Support For Puritymentioning

confidence: 99%

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Analysis of an Authentic Historical Italian Cosmetic Talc Sample – Further Evidence for the Lack of Cancer Risk

Ilgren¹,

Sartorio²,

Hoskins³

2017

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Italian talc from the Pinerolo Mines in North West Italy is known for its extreme purity. Several historical investigations of these mines have demonstrated very small amounts of tremolite in the host rock that occasionally found their way into the mined ore. However, more than sixty years of epidemiological studies of the Pinerolo miners and millers have failed to demonstrate any attendant cancer risk and show that this trace tremolite contamination is of no biological significance.Claims made that the Pinerolo Italian cosmetic talc produced prior to 1975 were contaminated with asbestos, principally tremolite, have been difficult to refute given the lack of authentic historical samples of commercial products. We now describe the analytical findings of a recently discovered authentic historical sample.Sample analyses of this material showed only a few non-asbestiform tremolite fibres -a finding discussed in the light of the historical (pre-1975) studies of this talc deposit: no serpentine (chrysotile) or amphibole fibres were detected.The numerical concentration of tremolite fibres in the talc sample was 3.687 x 10 6 fibres/gram, corresponding to a mass concentration of 0.722 parts per million.

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Section: Studies Of Talc Orementioning

confidence: 99%

Section: Epidemiological Support For Puritymentioning

confidence: 99%

Analysis of an Authentic Historical Italian Cosmetic Talc Sample – Further Evidence for the Lack of Cancer Risk

Ilgren¹,

Sartorio²,

Hoskins³

2017

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“…It could not be established whether talc had been involved in the induction of the carcinomas. 1992 persons who had started work between 1921 and 1950 in the Italian talc producing industry in Val Chisone were examined in a cohort study [35,36]. Italian talc is said to be free of asbestos but does contain quartz.…”

Section: Talc Deposits Without Detectable Asbestosmentioning

confidence: 99%

“…Similarly thickening of the pleura is observed after inhalation of talc dust [26,[35][36][37][38][39]41]. In particular the Italian and French studies justify the establishment of a MAK value to prevent this kind of pneumoconiosis [35][36][37][38][39].…”

Section: Manifesto (Classification/mak Value)mentioning

confidence: 99%

Talc (without asbestos fibres) [MAK Value Documentation, 1991]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 2 (1991) The article contains sections titled: Properties, Occurrence, Uses and Analysis Terminology Mineral characteristics Morphology, properties Occurrence Uses Analytical determination of asbestos and talc fibre content Fibre Content of Talcum Powders Effects in Man Talc deposits containing asbestos Talc deposits without detectable asbestos Effects on Animals Injection studies Inhalation studies Other application routes Manifesto (Classification/MAK Value)

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“…In contrast, relatively few epidemiological studies have investigated asbestos-related lung cancer mortality or incidence and its attributable risk in the general population [De Vos Irvine et al, 1993]. Piedmont is a region of northwestern Italy where occupational and environmental exposures to asbestos have been widespread [Rubino et al, 1972[Rubino et al, , 1979Vigliani, 1991]. The health consequences on workers employed in various industrial activities, such as asbestos-textile and mining, have been studied [Rubino et al, 1979].…”

mentioning

confidence: 99%

Asbestos-related lung cancer mortality in Piedmont, Italy

et al. 1998

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This study investigates the association between pleural neoplasm mortality, a possible proxy for asbestos exposure, and lung cancer mortality among males resident in Piedmont (northwestern Italy). Pleural neoplasm mortality was estimated in the 1,209 municipalities of the region for the period 1980–1992, applying Bayesian methods. The association with lung cancer mortality for municipalities was studied using Poisson regression. Urban/rural indicators and altitude were also included in the analysis. A positive, statistically significant association was found between pleural neoplasm and lung cancer mortality (β = 0.025, P < 0.001); lung cancer risk was associated also with urban status (vs. rural, β = 0.223,P < 0.001) and altitude (P = 0.01). The proportion of lung cancer deaths attributable to living in municipalities with increased pleural neoplasm mortality was 3.9% (95% confidence interval, 2.1–5.7%). The observed association and the presence of a dose‐response relationship at the municipality level underscore the dangers of asbestos for human health. Am. J. Ind. Med. 33:565–570, 1998. © 1998 Wiley‐Liss, Inc.

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Mortality Study of Talc Miners and Millers

Cited by 84 publications

References 0 publications

Analysis of an Authentic Historical Italian Cosmetic Talc Sample – Further Evidence for the Lack of Cancer Risk

Analysis of an Authentic Historical Italian Cosmetic Talc Sample – Further Evidence for the Lack of Cancer Risk

Talc (without asbestos fibres) [MAK Value Documentation, 1991]

Asbestos-related lung cancer mortality in Piedmont, Italy

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