Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

Hyun, Jiyu; Im, Jisoo; Kim, Sung-Won; Kim, Han Young; Seo, Inwoo; Bhang, Suk Ho

doi:10.3390/pharmaceutics13081155

Cited by 19 publications

(14 citation statements)

References 59 publications

(74 reference statements)

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“…AEMA induced the anagen phase by activating the β-catenin in DPCs, enhancing the growth factor secretion. The study showed that AEMA has hair growth-promoting potential [ 95 ]. AEMA increased the expression of proliferative and anti-apoptotic genes in human dermal fibroblasts and promoted the expression of hair-growth-related genes in DPCs.…”

Section: Role Of Phytochemicals In Hair Growthmentioning

confidence: 99%

Role and Mechanisms of Phytochemicals in Hair Growth and Health

et al. 2023

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Hair health is associated with personal distress and psychological well-being. Even though hair loss (alopecia) does not affect humans’ biological health, it affects an individual’s social well-being. So, treatment for hair problems and improving hair health are obligatory. Several pharmacological and cosmeceutical treatment procedures are available to manage hair loss and promote growth. Several factors associated with hair health include genetics, disease or disorder, drugs, lifestyle, chemical exposure, and unhealthy habits such as smoking, diet, and stress. Synthetic and chemical formulations have side effects, so people are moving towards natural compounds-based remedies for their hair problems. The history of using phytochemicals for hair health has been documented anciently. However, scientific studies on hair loss have accelerated in recent decades. The current review summarizes the type of alopecia, the factor affecting hair health, alopecia treatments, phytochemicals’ role in managing hair loss, and the mechanisms of hair growth-stimulating properties of phytochemicals. The literature survey suggested that phytochemicals are potent candidates for developing treatment procedures for different hair problems. Further detailed studies are needed to bring the scientific evidence to market.

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Section: Role Of Phytochemicals In Hair Growthmentioning

confidence: 99%

Role and Mechanisms of Phytochemicals in Hair Growth and Health

et al. 2023

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“…VEGF is a well-known angiogenesis-promoting growth factor that stimulates hair growth in both mice and humans. An increase in angiogenesis may accelerate anagen transition and hair follicle re-growth [ 10 ]. VEGF transgenic mice display an increased number and size of hair follicles compared to wild-type mice [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

Lee

Ham

Lee

et al. 2022

CIMB

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Hair loss is an important problem affecting the quality of life in modern society. Recent studies show that Annurca apple extract (AAE), enriched in procyanidin B2 and nutraceuticals, promotes hair growth and induces keratin production. In this study, we investigated the effects of AAE by orally administering AAE in six-week-old C57BL/6 mice once a day for 21 d. We observed improvement in hair length, thickness, weight, and density. The gene expression of two growth factors related to hair growth, vascular endothelial growth factor A (VEGFA) and fibroblast growth factor 7 (FGF-7), were measured using the quantitative reverse transcription polymerase chain reaction (qRT-PCR). The gene expression of both VEGFA and FGF-7 increased significantly in the AAE-treated group. Additionally, treatment with AAE suppressed the gene expression of type 1 5α-reductase. Histological analysis showed that protein levels of cytokeratin 5 and 10 were increased in the skin tissues of the AAE-treated group. These results suggest that AAE might be a potential therapeutic natural product that prevents hair loss by promoting the expression of hair growth-related factors.

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“…The formation of vessels‐like structures was examined and the images were taken by fluorescence microscope BZX710 (KEYENCE). The number of tube formations was counted by a researcher who was blind to the assay condition, as a previous report (Hyun et al, 2021 ; Li et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

CXCL10 is a novel anti‐angiogenic factor downstream of p53 in cardiomyocytes

Wahyuni

Tanaka

Igarashi

et al. 2022

Physiological Reports

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Tumor suppressor protein p53 plays crucial roles in the onset of heart failure. p53 activation results in cardiac dysfunction, at least partially by suppressing angiogenesis. Though p53 has been reported to reduce VEGF production by inhibiting hypoxia‐inducible factor, the anti‐angiogenic property of p53 remains to be fully elucidated in cardiomyocytes. To explore the molecular signals downstream of p53 that regulate vascular function, especially under normoxic conditions, DNA microarray was performed using p53‐overexpressing rat neonatal cardiomyocytes. Among genes induced by more than 2‐fold, we focused on CXCL10, an anti‐angiogenic chemokine. Real‐time PCR revealed that p53 upregulated the CXCL10 expression as well as p21, a well‐known downstream target of p53. Since p53 is known to be activated by doxorubicin (Doxo), we examined the effects of Doxo on the expression of CXCL10 and found that Doxo enhanced the CXCL10 expression, accompanied by p53 induction. Importantly, Doxo‐induced CXCL10 was abrogated by siRNA knockdown of p53, indicating that p53 activation is necessary for Doxo‐induced CXCL10. Next, we examined the effect of hypoxic condition on p53‐mediated induction of CXCL10. Interestingly, CXCL10 was induced by hypoxia and its induction was potentiated by the overexpression of p53. Finally, the conditioned media from cultured cardiomyocytes expressing p53 decreased the tube formation of endothelial cells compared with control, analyzed by angiogenesis assay. However, the inhibition of CXCR3, the receptor of CXCL10, restored the tube formation. These data indicate that CXCL10 is a novel anti‐angiogenic factor downstream of p53 in cardiomyocytes and could contribute to the suppression of vascular function by p53.

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Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

Cited by 19 publications

References 59 publications

Role and Mechanisms of Phytochemicals in Hair Growth and Health

Role and Mechanisms of Phytochemicals in Hair Growth and Health

An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice

CXCL10 is a novel anti‐angiogenic factor downstream of p53 in cardiomyocytes

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