Moscow Eye Microsurgery Complex in Russia Keratoprosthesis in Beijing

Huang, Yifei; Yu, Jifeng; Liu, Li; Du, Gaiping; Song, Jing; Guo, Huiling

doi:10.1016/j.ophtha.2010.05.019

Cited by 36 publications

(32 citation statements)

References 16 publications

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“…Many Kpro devices have been developed over the past decades, including AlphaCor, 2,3 Boston Keratoprosthesis (Boston Kpro), 4 osteo-odonto keratoprosthesis (OOKP), 5 and the Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis. 6,7 The Boston Kpro and OOKP, the most commonly used Kpros, have been used to treat patients with multiple graft failures, aniridia, chemical injuries, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and thermal burns as well as other conditions with high risk of corneal graft rejection and failure. 8 The differentiation in use of the two most commonly used Kpros is in the condition of the ocular surface before treatment.…”

mentioning

confidence: 99%

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt

Tan

Thompson

Konstantopoulos

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Synthetic keratoprostheses are required for visual rehabilitation in patients with endstage corneal blindness. This study aimed to assess the biocompatibility of graphene material and its potential as a novel synthetic keratoprosthesis skirt material for corneal tissue engineering. METHODS.Human corneal stromal fibroblasts were cultured on material surfaces including pristine graphene film, graphene foam, pristine titanium (Ti) discs, and tissue culture plastic surface (TCPS). Cell attachment was assayed by immunostaining of paxillin and vinculin. Cell viability and proliferation were assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and Click iT 5-ethynyl-2 0 -deoxyuridine (EdU) assays. The growth of fibroblasts on three-dimensional graphene foam was examined by scanning electron microscopy, and cytokine release was analyzed by enzyme-linked immunosorbent assay. Graphene films were implanted into rabbit corneal stromal pockets and examined by slit-lamp biomicroscopy, anterior segment optical coherence tomography, in vivo confocal microscopy, and histology.RESULTS. Pristine graphene demonstrated good biocompatibility with human stromal fibroblasts in terms of cell adhesion, viability, and proliferation. Cells on graphene films showed higher number than on TCPS control. Cells grown on graphene had 10% more proliferation than on Ti. The expression levels of IL-6 and IL-8 were reduced when cells were seeded on graphene foam as compared to Ti and graphene film. Implantation of graphene film into rabbit stroma (n ¼ 6) did not show any signs of infection, neovascularization, or inflammation.CONCLUSIONS. Graphene displayed excellent short-term biocompatibility with corneal cells and tissue. This demonstrates that graphene can be developed as a tissue engineering material for use in cornea.

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mentioning

confidence: 99%

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt

Tan

Thompson

Konstantopoulos

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…66 Historical series have reported incidence rates ranging from 0e10%, with many studies below 5%. 2,3,10,15,47,49,51,63,65,76,79 A more recent series found a higher rate of 14.3% in a cohort of 83 eyes. 36 No associations with initial diagnosis, comorbidities, or other risk factors have been identified.…”

Section: Sterile Vitritis/uveitismentioning

confidence: 95%

“…6,15,41,51,75,76,79 Case series with more than 50 eyes have consistently reported incidence rates of approximately 50%. 2,3,47,67 In one of the largest series, consisting of 265 eyes, the incidence was 31.7%. 78 The time interval between surgery and development of RPM varies from weeks to months, with appearance as early as 1 week and as late as 49 months.…”

Section: Retroprosthetic Membranementioning

confidence: 99%

“…78 The time interval between surgery and development of RPM varies from weeks to months, with appearance as early as 1 week and as late as 49 months. 2,47,76 Risk factors for RPM include postoperative inflammation, 75,76 multiple procedures (such as cataract extraction, vitrectomy, intraocular lens placement or removal, and tube shunt implantation), 2,76 retinal detachment, 67 infectious keratitis, 78 and aniridia. 78 Non-ocular factors have also been cited, including African and Caribbean ancestry and systemic illnesses such as hypertension and diabetes.…”

Section: Retroprosthetic Membranementioning

confidence: 99%

“…11 Currently, the three most widely used KPros are the Boston KPro (available in type I, 26 type II, 69 and newer low-cost 'Lucia modification', used primarily outside the United States), the osteo-odonto keratoprosthesis (OOKP), 31 and the AlphaCor. 44 Other less commonly used devices include the Worst KPro (used primarily in India), the Fyodorov-Zuev KPro, 35 and the Moscow Eye Microsurgery Complex in Russia KPro (both used in Russia), 46,47 and the Legeais and Lacombe KPros in France.…”

mentioning

confidence: 99%

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Vitreoretinal aspects of permanent keratoprosthesis

Klufas

Yannuzzi

D’Amico

et al. 2015

Survey of Ophthalmology

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Dual functionalization of titanium with vascular endothelial growth factor and β‐defensin analog for potential application in keratoprosthesis

et al. 2012

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Functionalization of material surfaces can improve their biointegration and bactericidal effect. To expand the biomedical applications of titanium in artificial cornea implantation surgery, titanium alloy substrates were coated with polydopamine and dual bound with recombinant vascular endothelial growth factor (VEGF) and anti‐microbial peptide (AMP), SESB2V. Successful chemical binding was assessed with attenuated total reflectance‐Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy. Coating thickness was assessed by atomic force microscopy. Cellular studies revealed that the functionalized substrates displayed the abilities to enhance primary human corneal fibroblast adhesion, proliferation, and viability. Angiogenesis assay with human mesenchymal stem cells was used to verify the biological functions of immobilized VEGF while bactericidal assay was evaluated for the anti‐microbial activities of immobilized SESB2V peptide. We found that the titanium surface that was sequentially functionalized with VEGF and SESB2V had enhanced fibroblast proliferation and anti‐microbial properties. The incorporation of such peptides into an artificial cornea implant is important for implant‐tissue integration and wound healing. This may improve implant integration and reduce the risk of device infection following artificial cornea implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.

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Moscow Eye Microsurgery Complex in Russia Keratoprosthesis in Beijing

Cited by 36 publications

References 16 publications

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt

Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt

Vitreoretinal aspects of permanent keratoprosthesis

Dual functionalization of titanium with vascular endothelial growth factor and β‐defensin analog for potential application in keratoprosthesis

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