Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice

Dexamethasone attenuates methacholine‐mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF‐κB activation

“…Shikani et al showed that the epithelial expression of AQP5 was significantly lower in patients with nasal polyps compared with controls . In animal models induced by lipopolysaccharide or adenovirus, AQP5 expression is decreased in lung inflammation or lung injury . In addition, AQP5 has a protective effect against the edema induced by mechanical ventilation .…”

“…NF‐κB is an inducible cellular transcription factor and plays a vital role in the regulation of cytokine networks of inflammatory airway diseases. In rats with induced lung injury, treatment that downregulates NF‐κB pathway increases AQP5 expression, which improves pulmonary function in vivo . Yao et al showed that injection of lipopolysaccharides (LPS) led to downregulation of AQP5 mRNA in the parotid gland of mice and that NF‐κB–responsive, but not AP‐1–responsive, elements present at the promoter region of the AQP5 gene were increased .…”

Antiviral activities of atractylon from Atractylodis Rhizoma

“…For the model control group, the mice were only given saline at the same intervals. The mice were observed daily for changes in weight, and survivability ( 18 ). To monitor the histological changes and challenge dose of the virus in the lungs of IAV-infected animal, 10 mice per group were sacrificed to calculate lung index and viral load after day 6 post-infection.…”

Advances in research on the effects of aquaporins on animal health

“…这可能是由 于LPS处理导致肉鸡体内水通道蛋白功能异常, 致使 转运水的能力有所降低, 造成肺内水和离子无法正常 运输, 使肺呈现水肿, 造成肺损伤. 这与先前报道的 AQP5在肺水肿中调节去除多余水分的能力不谋而 合 [56] . 也有些研究表明, 仔猪断奶应激会使仔猪胃肠 道特定部位的AQP1, 3, 8, 11的表达出现显著下调, 这 可能与断奶应激引起的腹泻密不可分 [57,58] .…”

“…在家禽组织器 官中, 鸡体内AQPs在脑的渗透调节和卵巢卵泡发育 的水运输调节等方面发挥重要作用 [65~67] . 在肺组织 中, 已经发现至少有4种AQPs(AQP1, 3, 4, 5)的存 在 [56] , 并且在构建的哮喘动物模型中发现, 肺内AQP1 的表达水平与哮喘呈现正相关 [68] . 同时相关研究也证 实, 在AQP5缺失的小鼠中, 紧密连接减少, 气道黏膜 下腺的液体分泌减少, 气道上皮屏障功能减弱, 更易 被过敏原侵入 [69] .…”