Mosquito Larvicidal Constituents from the Ethanol Extract ofInula racemosaHook. f. Roots againstAedes albopictus

He, Qing; Liu, Xin Chao; Sun, Rui; Deng, Zhi Wei; Du, Shu Shan; Liu, Zhi Long

doi:10.1155/2014/738796

Cited by 19 publications

(10 citation statements)

References 32 publications

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“…In addition, six relevant lactones 3,4-dehydroalantolactone (3), 5 ,6 -epoxyalantolactone (4), 6-hydroxyl alantolactone (5), 4-hydroxymethyl isolalantolactone (6), 11-carboxyl alantolactone (7), and 11-carboxyl alantolactone (8) were obtained. Their structures were confirmed by MS and NMR determination [14][15][16][17][18][19].…”

Section: Preparation Of Alantolactone Isoalantolactone and Othermentioning

confidence: 99%

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Wang

Peng

et al. 2018

Journal of Chemistry

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Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix. Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time. As a result, nine metabolites in vivo including cysteine conjugates, oxidates, dehydrogenates, and hydrates were detected in rat bile after oral administration. The metabolites produced in vitro by incubation with rat liver microsomes were found to be substantially identical to those detected in vivo. However, no metabolites were detected in the samples of plasma, feces, and urine or in the incubates of gastric juice, intestinal juice, and intestinal bacteria. These results reveal that the liver is the main metabolic organ for alantolactone and isoalantolactone, and the first pass effect of the liver appears to be the reason for the low oral bioavailability of the two lactones.

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Section: Preparation Of Alantolactone Isoalantolactone and Othermentioning

confidence: 99%

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Wang

Peng

et al. 2018

Journal of Chemistry

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“…Studies of the essential oils and extracts derived from such plants as Clinopodium gracile [4], Saussurea lappa [5], Toddalia asiatica [6], Inula racemosa [7], Isodon japonicus var. glaucocalyx [8], and many other plants have demonstrated promising larvicidal activities against mosquito vectors.…”

Section: Introductionmentioning

confidence: 99%

Larvicidal activity of the essential oil of Youngia japonica aerial parts and its constituents against Aedes albopictus

Liu

Chen

et al. 2015

Zeitschrift Für Naturforschung C

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The aim of this study was to evaluate the larvicidal activity of the essential oil of Youngia japonica aerial parts against the larvae of Aedes albopictus and to isolate any active compounds from the oil. Gas chromatography-mass spectrometry (GC-MS) analyses revealed the presence of 31 compounds, with menthol (23.53%), α-asarone (21.54%), 1,8-cineole (5.36%), and caryophyllene (4.45%) as the major constituents. Bioactivity-directed chromatographic separation of the oil led to the isolation of menthol and α-asarone as active compounds. The essential oil of Y. japonica exhibited larvicidal activity against the fourth instar larvae of A. albopictus with an LC₅₀ value of 32.45 μg/mL. α-Asarone and menthol possessed larvicidal activity against the fourth instar larvae of A. albopictus with LC₅₀ values of 24.56 μg/mL and 77.97 μg/mL, respectively. The results indicate that the essential oil of Y. japonica aerial parts and the two constituents can be potential sources of natural larvicides.

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“…Fortunately, natural products derived from plants including essential oils can provide an alternate to synthetic chemical insecticides [2]. Many essential oils and their constituents can exert toxic activity against mosquito species [3][4][5][6][7][8][9][10]. During the present author's mass screening program for new agrochemicals from wild plants, the essential oil of Salvia plebeian R.Br.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Salvia plebeian R.Br. Essential Oil and its Larvicidal Activity against Aedes aegypti L

Zhu¹,

Liu²,

Liu³

et al. 2015

Trop. J. Pharm Res

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Purpose: To evaluate the larvicidal activity of the essential oil of Salvia plebeian R.Br. (Labiatae) aerial parts against the larvae of Aedes aegypti L. Methods: The essential oil of S. plebeian aerial parts was obtained by hydro-distillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The essential oil was evaluated for larvicidal activity using World Health Organization (WHO) procedures, against the fourth larvae of A. aegypti within 24 h, and activity was recorded for various concentrations of the

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Mosquito Larvicidal Constituents from the Ethanol Extract ofInula racemosaHook. f. Roots againstAedes albopictus

Cited by 19 publications

References 32 publications

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Larvicidal activity of the essential oil of Youngia japonica aerial parts and its constituents against Aedes albopictus

Chemical Composition of <i>Salvia plebeian</i> R.Br. Essential Oil and its Larvicidal Activity against <i>Aedes aegypti</i> L

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