Mosquitocidal, Antimalarial and Antidiabetic Potential of Musa paradisiaca-Synthesized Silver Nanoparticles: In Vivo and In Vitro Approaches

Abstract

The development of pathogens and parasites resistant to synthetic drugs has created the need for developing alternative approaches to fight vector-borne diseases. In this research, we fabricated green-synthesized silver nanoparticles (AgNP) using Musa paradisiaca stem extract as a reducing and stabilizing agent. AgNP showed plasmon resonance reduction under UV-Vis spectrophotometry, SEM and XRD highlighted that they were crystalline in nature with face centered cubic geometry. . AgNP showed growth inhibition activity against bacteria and fungi of public health relevance. AgNP were a valuable candidate for treatment of diabetes in STZ-treated rat by normalizing glucose, galactose and insulin. AgNP were toxic against larvae and pupae of the malaria vector Anopheles stephensi, with LC 50 of 3.642 (I), 5.497 (II), 8.561 (III), 13.477 (IV), and 17.898 ppm (pupae), respectively. Furthermore, the antiplasmodial activity of nanoparticles was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum, IC 50 were 84.22 lg/ml (CQ-s) and 89.24 lg/ml (CQ-r), while chloroquine IC 50 were 86 lg/ml (CQ-s) and 91 lg/ml (CQ-r). Overall, we add knowledge on the multipurpose effectiveness of green-fabricated nanoparticles in medicine and parasitology, which can be potentially helpful to develop newer and safer antiplasmodial agents and vector control tools.

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

“…A remarkable increase in insulin levels as well as a decrease in blood sugar and HbA1c was observed in the STZ-induced diabetic rats treated with AgNPs. Increase in glucose uptake and the induction of insulin secretion are the possible mechanisms responsible for these observations (Anbazhagan et al, 2017).…”

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

“…Similarly, Allium cepa extract-AgNPs were synthesized and tested in vitro; the results showed significant inhibition of carbohydrate digestive enzymes (α-glucosidase and α-amylase) comparable to acarbose and free radical-scavenging ability (Jini and Sharmila, 2020). In vivo studies of Musa paradisiaca stem extract-mediated synthesized silver nanoparticles on diabetic rats have also shown suitable antidiabetic effects by decreasing the levels of blood glucose and glycosylated hemoglobin [ 249 ]. Similar effects have been reported using Solanum nigrum leaf extract-AgNPs [ 250 ] and Zingiber officinales extract-AgNPs [ 251 ].…”

Protection of silver nanoparticles using <em>Eysenhardtia polystachya</em> in peroxide-induced pancreatic &beta;-Cell damage and their antidiabetic properties in zebrafish

“…11 Green synthesized-silver nanoparticles (AgNPs) using Musa paradisiaca stem extract were also a potent drug against diabetes in the streptozotocin (STZ)induced diabetes rat model. 12 In another study, AgNPs using ethanolic extract of ginger rhizome (Zingiber officinale) had a notable effect on blood glucose lowering in rats with STZ-induced diabetes. 13 The biosynthesis of AgNPs is a promising alternative to physicochemical methods, which limit the use of hazardous and toxic substances and are energy consuming.…”