Mössbauer spectroscopy: Application in biomedical research

Оштрах, М. И.

doi:10.1007/s10751-006-9284-7

Cited by 16 publications

(3 citation statements)

References 95 publications

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“…The direct observation of the 57 Fe hyperfine interactions is possible by using 57 Fe Mössbauer spectroscopy. This powerful technique was widely applied in various fields of the life sciences since 1960s (for reviews see, for instance, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]). Since 2006 we are developing the high velocity resolution Mössbauer spectroscopy which significantly increases the analytical possibilities of the technique with decreasing the instrumental (systematic) error in evaluation of the 57 Fe hyperfine parameters and the most reliable fitting of complicated Mössbauer spectra.…”

Section: Introductionmentioning

confidence: 99%

The 57Fe hyperfine interactions in the life sciences: application of Mössbauer spectroscopy with a high velocity resolution in the study of iron-containing biomolecules and pharmaceutical compounds

Оштрах

Alenkina

Виноградов

et al. 2016

J Radioanal Nucl Chem

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The 57 Fe hyperfine interactions are the useful source of information about the finest structural peculiarities in various iron-containing proteins which can be essential in the natural variety of structure and function relationship in normal biomolecules as well as in its changes in the case of molecular pathology. Mössbauer spectroscopy with a high velocity resolution as the most sensitive probe for the 57 Fe hyperfine interactions demonstrates some advances in the study of various hemoglobins, ferritins and pharmaceutical products that can bring new information for the life sciences.Keywords Mössbauer spectroscopy with a high velocity resolution Á The 57 Fe hyperfine interactions Á Ironcontaining biomolecules Á Iron-containing pharmaceutical compounds

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Section: Introductionmentioning

confidence: 99%

The 57Fe hyperfine interactions in the life sciences: application of Mössbauer spectroscopy with a high velocity resolution in the study of iron-containing biomolecules and pharmaceutical compounds

Оштрах

Alenkina

Виноградов

et al. 2016

J Radioanal Nucl Chem

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“…Magnetic fluids incorporating biocompatible characteristics can be used as contrast agents for magnetic resonance imaging, drug carrier and delivery, local hyperthermia effect, etc. Typical biocompatible magnetic fluids consist of iron-containing magnetic nanoparticles [1][2][3], thus allowing Mössbauer spectroscopy to be used as an important investigation tool which has been very useful in various biomedical research [4][5][6]. There are various applications of Mössbauer spectroscopy including the study of magnetic nanoparticles for magnetic fluid development (see, for instance [7]).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of iron oxide nanoparticles as-prepared and dispersed in Copaiba oil using Mössbauer spectroscopy with low and high velocity resolution

Оштрах

Šepelák

Rodriguez

et al. 2013

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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a b s t r a c tIron oxide nanoparticles, probably magnetite, as-prepared and dispersed in Copaiba oil were studied by Mössbauer spectroscopy using two different spectrometers: with a low velocity resolution (512 channels) for measurements at 295 and 21 K and with a high velocity resolution (4096 channels) for measurements at 295 and 90 K. The fitting of all measured spectra demonstrated that usual models applied to fit Möss-bauer spectra of magnetite and maghemite particles were not suitable. Therefore, the recorded spectra were fitted using a large number of spectral components on the basis of better quality of the fit and linearity of differential spectra. The number of components obtained for the better fit appeared to be different for spectra measured with a low and a high velocity resolution. However, these results demonstrated differences of Mössbauer parameters for iron oxide nanoparticles as-prepared and dispersed in Copaiba oil at applied temperatures. The effect of Copaiba oil molecules on Mössbauer parameters may be a result of the interactions of polar molecules such as kaurinic acid with nanoparticles' surface.

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“…Some pathological states of the body are caused by environmental factors that may affect biological molecules, cells and tissues. Therefore, Mössbauer spectroscopy was successfully applied for studying biomolecules containing iron in normal and pathological cases [4,7,10,11].…”

Section: Introductionmentioning

confidence: 99%

Biomedical application of Mössbauer spectroscopy with a high velocity resolution: Revealing of small variations

et al. 2010

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Application of Mössbauer spectroscopy with a high velocity resolution for study different hemoglobins, ferritin, its models and chicken liver and spleen as well as normal and lymphoid chicken spleen demonstrated revealing of small variations of hyperfine parameters related to small variations of iron stereochemistry in biomolecules. These data demonstrate that Mössbauer spectroscopy with a high velocity resolution may be useful in biomedical research to distinguish small variations of iron-containing proteins in normal and pathological cases.

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Mössbauer spectroscopy: Application in biomedical research

Abstract: The results of the application of Mössbauer spectroscopy in biomedical research were briefly reviewed. The main directions of biomedical application and possibilities of Mössbauer spectroscopy to study the molecular nature of diseases were considered.

Cited by 16 publications

References 95 publications

The 57Fe hyperfine interactions in the life sciences: application of Mössbauer spectroscopy with a high velocity resolution in the study of iron-containing biomolecules and pharmaceutical compounds

The 57Fe hyperfine interactions in the life sciences: application of Mössbauer spectroscopy with a high velocity resolution in the study of iron-containing biomolecules and pharmaceutical compounds

Comparative study of iron oxide nanoparticles as-prepared and dispersed in Copaiba oil using Mössbauer spectroscopy with low and high velocity resolution

Biomedical application of Mössbauer spectroscopy with a high velocity resolution: Revealing of small variations

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