Motor and bladder dysfunctions in patients with vertebral fractures at the thoracolumbar junction

Chen, Sung‐Lang; Huang, Yu-Hui; Wei, Tsung-Yu; Huang, Kang-Ming; Ho, Sin-Haw; Bih, Liu-Ing

doi:10.1007/s00586-011-2062-5

Cited by 17 publications

(11 citation statements)

References 13 publications

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“…Data on the prevalence of bladder/bowel incontinence and sexual dysfunction among individuals with traumatic TLSCI in the community is scarce as most studies include both traumatic and non-traumatic TLSCI. 11,[15][16][17][29][30][31] While the prevalence of selfreported bladder/bowel incontinence and sexual dysfunction from our study fits within the range of published literature, a direct comparison is difficult as the definition of dysfunctions, measures used, participant Note that P values below the threshold of statistical significance (P < 0.05) have been bolded. populations and follow-up times vary.…”

Section: Discussionmentioning

confidence: 80%

Impact of bladder, bowel and sexual dysfunction on health status of people with thoracolumbar spinal cord injuries living in the community

Park

Elliott

Noonan

et al. 2016

The Journal of Spinal Cord Medicine

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Section: Discussionmentioning

confidence: 80%

Impact of bladder, bowel and sexual dysfunction on health status of people with thoracolumbar spinal cord injuries living in the community

Park

Elliott

Noonan

et al. 2016

The Journal of Spinal Cord Medicine

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“…Data were presented as the mean ± s.d. Student's t-test was used for continuous or discrete data analysis, as described [20,23]. All statistical tests were two-sided (SEM), and values of p < 0.05 were considered statistically significant (*p < 0.05; ** p < 0.01; *** p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

Wang

Chang

et al. 2021

Cancers

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Azacitidine, an inhibitor of DNA methylation, shows therapeutic effects against several malignancies by inducing apoptosis and inhibiting tumor cell proliferation. However, the anti-tumor effects of azacitidine on urinary bladder urothelial carcinoma (UBUC), especially following intravesical instillation (IVI), are not established. Here, UBUC cell lines were used to analyze the in vitro therapeutic effects of azacitidine. Potential signaling pathways were investigated by antibody arrays and Western blotting. The N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced rat UBUC model was used for in vivo quantitative analysis of tumor burden. Azacitidine significantly inhibited DNMT expression in UBUC cell lines and reduced cell viability and clonogenic activity, as determined by MTT and colony formation assays, while also inducing significant cytotoxic effects in the form of increased sub-G1 and Annexin V-PI populations (all p < 0.05). Antibody arrays confirmed the in vitro suppression of TNF-R1 and the induction of TRAIL-R2 and their downstream signaling molecules. TNF-R1 suppression reduced claspin and survivin expression, while TRAIL-R2 activation induced cytochrome C and caspase 3 expression. Rats with BBN-induced bladder cancer had a significantly reduced tumor burden and Ki67 index following IVI of azacitidine (p < 0.01). Our study provides evidence for a reduction in BBN-induced bladder cancer by IVI of azacitidine through alterations in the TRAIL-R2 and TNF-R1 signaling pathways. These findings might provide new insights for further clinical trials.

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“…Chen et al. examined 52 patients with vertebral fracture at thoracolumbar junction (T11-T12-L1-L2); spastic neurogenic bladder dysfunction was most seen at T11, T12 lesion, flaccid neurogenic bladder dysfunction was most seen at L2 level [20]. The conus medullaris, the terminal segment of the adult spinal cord, usually lies at L1 vertebra of most adults.…”

Section: Discussionmentioning

confidence: 99%

Surgical outcomes in thoracolumbar fractures with pure conus medullaris syndrome

Chiu

Liao

2019

Biomedical Journal

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BackgroundPure conus medullaris syndrome is defined as a combination of signs and symptoms of bladder/bowel incontinence and impotence without the presence of lower limbs weakness. The purpose of the study is to assess the recovery of voiding, sexual, and sensory function in patients with isolated conus medullaris syndrome after surgical treatments.MethodsFrom January 2005 to December 2012, patients with a single level burst fracture with pure conus medullaris syndrome were assessed. Level of injury, use of steroid, surgical time, surgical approach, preoperative radiographic parameters, and types of neurogenic bladder were recorded. Bladder function was evaluated using urodynamic study; sexual function was assessed by self-report questionnaire. The final outcomes were focused on the recovery of voiding, sexual, and sensory function.ResultsEight patients met the criteria of pure conus medullaris syndrome with thoracolumbar burst fracture. The injury level were all located at L1 vertebra. There were 6 males and 2 females. Four patients had overactive neurogenic bladder, and the other 4 patients had underactive type. At final, five patients regained self-voiding function, and three required intermittent catheterization. Two male patients were sexually active, and four male patients had some sexual dysfunction. Two female patients could have normal sexual intercourse but the frequency decreased. One female patients had prolonged perineum numbness at final follow-up.ConclusionsAlthough extremely rare, pure conus medullaris syndrome may occur with L1 burst fracture. Despite surgical treatment, only one half of the patients regained normal bladder and sexual function.

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Motor and bladder dysfunctions in patients with vertebral fractures at the thoracolumbar junction

Cited by 17 publications

References 13 publications

Impact of bladder, bowel and sexual dysfunction on health status of people with thoracolumbar spinal cord injuries living in the community

Impact of bladder, bowel and sexual dysfunction on health status of people with thoracolumbar spinal cord injuries living in the community

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

Surgical outcomes in thoracolumbar fractures with pure conus medullaris syndrome

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