Motor Blocking Minimum Local Anesthetic Concentrations of Bupivacaine, Levobupivacaine, and Ropivacaine in Labor

Abstract

This study confirms a motor blocking hierarchy for the three pipecoloxylidines.

Effect of Intrathecal Levobupivacaine and Bupivacaine With Fentanyl on Postoperative Ambulation and Analgesia: A Randomized Controlled Trial.

“…Also in considering the results from representative analgesic and motor block MLAC studies done by Lacassie (2002), Columb (1995), Lyons (1998), it appears that levobupivacaine widen the sensory-motor fibers separation for the pipecoloxylidine homologous series of local anaesthetics that have the ability to cause differential sensory and motor neuronal blockade. [6] Our study also evince that the duration of effective analgesia in Levobupivacaine group has the mean of 360.86±42.10 min collated with the mean of 347.14±39.37 min in Bupivacaine group which was significant clinically (Fig. 3) Bupivacaine appreciated in our study.…”

“…[5] Hector et al also discussed while comparing Relative Motor Blocking Potencies that levobupivacaine may demonstrate greater apparent sensory-motor dissociation than racemic bupivacaine, especially if the results are expressed in molar terms. [6] This translates to approximately 25% reduction in motor block potency due to the difference in the expressed formulation of levobupivacaine. Also in considering the results from representative analgesic and motor block MLAC studies done by Lacassie (2002), Columb (1995), Lyons (1998), it appears that levobupivacaine widen the sensory-motor fibers separation for the pipecoloxylidine homologous series of local anaesthetics that have the ability to cause differential sensory and motor neuronal blockade.…”

Patient-Controlled Epidural Levobupivacaine with or without Fentanyl for Post-Cesarean Section Pain Relief

“…The first parturient in each group received 1.2 mg/mL levobupivacaine, and the parturients in group 1 received an additional 2 mcg/mL of fentanyl. This concentration of levobupivacaine was chosen because it was between the motor blocking minimum local anesthetic concentration and minimum local analgesic concentration of levobupivacaine based on Lacassie et al [11] and Robinson et al's [12] studies, respectively. A basal infusion of 3 mL/h and a bolus of 2 mL were selected.…”

Continuous patient‐controlled epidural infusion of levobupivacaine plus sufentanil in labouring primiparous women: effects of concentration*

“…Levobupivacaine, the pure S ())-enantiomer of bupivacaine, has emerged as a safer alternative than its racemic parent [1,2]. It has been claimed to be more potent than bupivacaine [3,4] or ropivacaine [5], and to cause less motor impairment [4,[6][7][8], although there is little evidence to support this [1]. Levobupivacaine is commercially available in France in pre-filled bags at two different concentrations (0.625 and 1.25 mg.ml )1 ).…”