MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice

Bello-Arroyo, Elísabet; Roque, Hélio; Marcos, Alberto; Orihuel, Javier; Higuera-Matas, Alejandro; Desco, Manuel; Caiolfa, Valeria R.; Ambrosio, Emilio; Lara‐Pezzi, Enrique; Gómez-Gaviro, Marı́a Victoria

doi:10.3389/fnbeh.2018.00201

Cited by 38 publications

(30 citation statements)

References 32 publications

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“…The animal behavioral test is essential to understand the bases of neurologic and psychological disorders (Bello-Arroyo et al, 2018). The Y-maze test was implemented to assess immediate spatial working memory of animals (Xu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Wang

Chen

Shen

et al. 2019

Front. Aging Neurosci.

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Amyloid-β (Aβ) deposits and some proteins play essential roles in the pathogenesis of Alzheimer's disease (AD). Amide proton transfer (APT) imaging, as an imaging modality to detect tissue protein, has shown promising features for the diagnosis of AD disease. In this study, we chose 10 AD model rats as the experimental group and 10 sham-operated rats as the control group. All the rats underwent a Y-maze test before APT image acquisition, using saturation with frequency alternating RF irradiation (APT SAFARI) method on a 7.0 T animal MRI scanner. Compared with the control group, APT (3.5 ppm) values of brain were significantly reduced in AD models (p < 0.002). The APT SAFARI imaging is more significant than APT imaging (p < 0.0001). AD model mice showed spatial learning and memory loss in the Y-maze experiment. In addition, there was significant neuronal loss in the hippocampal CA1 region and cortex compared with sham-operated rats. In conclusion, we demonstrated that APT imaging could potentially provide molecular biomarkers for the non-invasive diagnosis of AD. APT SAFARI MRI could be used as an effective tool to improve the accuracy of diagnosis of AD compared with conventional APT imaging.

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Section: Discussionmentioning

confidence: 99%

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Wang

Chen

Shen

et al. 2019

Front. Aging Neurosci.

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“…54 Automated detection systems for assessing animal behaviors are worth considering in terms of saving time, achieving an objective analysis and reducing the need of well-trained experimenters. 54,55 Hayashi et al 54…”

Section: Automated Behavior Analysismentioning

confidence: 99%

Possible implications of animal models for the assessment of visceral pain

Regmi

Shah

2020

Anim Models and Exp Med

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Visceral pain is the most common but challenging problem seen in clinical patients. Approximately a quarter to a half of the world population experience visceral pain at least once during their life span, which leads to substantial health care costs. 1 Inflammation, ischemia, or mesenteric stretching or distention of the hollow organs of the thoracic, pelvic, or abdominal cavities stimulate the afferent nociceptors to activate the pain pathways. 2 The activated fibers transmit the nociceptive signals to the spinal dorsal horn (SDH) and then to the central nervous system (CNS), resulting in visceral pain. 3 Visceral pain is diffuse in nature and is thereby very difficult to localize. 4,5

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“…al 16 . Test and conditioning times were measured with a stopwatch, and the video recording was analysed using ImageJ 15 and MouBeAT 17 . On day 1, male Arg3.1-Cre/ER T2 mice expressing hM3DGq or EGFP were placed in the CPP apparatus and allowed to explore freely for 10 min without saline or CLZ injection to determine intrinsic place preference.…”

Section: Conditioned Place Preference (Cpp) Testmentioning

confidence: 99%

Activation of prodynorphin neurons in the dorsomedial hypothalamus inhibits food intake and promotes positive valence

Imoto

Yamamoto

Matsunaga

et al. 2020

Preprint

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AbstractThe regulation of food intake is one of the major research areas in the study of metabolic syndromes such as obesity. Gene targeting studies have clarified the roles of hypothalamic neurons in feeding behaviour. However, our understanding of neural function under physiological conditions is still limited. Immediate early genes, such as activity-regulated cytoskeleton-associated protein (Arc/Arg3.1), are useful markers of neuronal activity. Here, we investigated the role of Arc/Arg3.1 gene-expressing neurons in the hypothalamus after refeeding using the targeted recombination in active populations method. We identified refeeding-responsive prodynorphin/cholecystokinin neurons in the dorsomedial hypothalamus that project to the paraventricular hypothalamic nucleus. Chemogenetic activation of these neurons decreased food intake and promoted positive valence. Our findings provide insight into the role of newly identified hedonic neurons in the process of feeding-induced satiety.

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MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice

Cited by 38 publications

References 32 publications

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method

Possible implications of animal models for the assessment of visceral pain

Activation of prodynorphin neurons in the dorsomedial hypothalamus inhibits food intake and promotes positive valence

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