Mouse Genetics and Metabolic Mouse Phenotyping

Fuchs, Helmut; Neschen, Susanne; Rozman, Jan; Rathkolb, Birgit; Wagner, Sibylle; Adler, Thure; Afonso, Luciana Caminha; Aguilar-Pimentel, Juan Antonio; Becker, Lore; Bohla, Alexander; Calzada‐Wack, Julia; Cohrs, Christian M.; Frankó, András; Garrett, Lillian; Glasl, Lisa; Götz, Alexander; Hagn, Michael; Hans, Wolfgang; Hölter, Sabine M.; Horsch, Marion; Kahle, Melanie; Kistler, Martin; Klein-Rodewald, Tanja; Lengger, Christoph; Ludwig, Tonia; Maier, Holger R.; Marschall, Susan; Micklich, Kateryna; Möller, Gabriele; Naton, Beatrix; Neff, Frauke; Prehn, Cornelia; Puk, Oliver; Rácz, Ildikó; Räß, Michael; Scheerer, Markus F.; Schiller, Evelyn; Schöfer, Felix; Schrewe, Anja; Steinkamp, Ralph; Stöger, Claudia; Treise, Irina; Willershäuser, Monja; Wolff-Muscate, Annemarie; Zeh, Ramona; Adamski, Jerzy; Beckers, Johannes; Bekeredjian, Raffi; Busch, Dirk H.; Favor, Jack; Graw, Jochen; Katus, Hugo A.; Klopstock, Thomas; Ollert, Markus; Schulz, Holger; Stöger, Tobias; Wurst, Wolfgang; Yildirim, Ali Önder; Zimmer, Andreas; Wolf, Eckhard; Klingenspor, Martin; Gailus‐Durner, Valérie; Angelis, Martin Hrabé de

doi:10.1007/978-1-4614-1689-0_7

Cited by 1 publication

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma triglyceride (TG), nonesterified fatty acid (NEFA), creatinine, creatine kinase, urea, and C-reactive peptide levels were quantified by routine clinical chemistry using an AU480 analyzer (Beckman Coulter, Krefeld, Germany) (11). Blood glucose and hemoglobin A 1c levels were measured in tail blood samples using a glucometer (Contour, Bayer, Germany) and the Clover A1c Self system (Obelis, Belgium).…”

Section: Animal Studiesmentioning

confidence: 99%

“…Body composition and energy balance were determined by quantitative nuclear magnetic resonance (MiniSpec LF60; Bruker Optics, Ettlingen, Germany). Indirect calorimetry (PhenoMaster System; TSE Systems, Bad Homburg, Germany) was conducted as described previously (11). A linear regression model, including body weight as a covariate, was used to adjust for body weight-dependent differences in energy metabolism parameters (TIBCO Spotfire S+ 8.1 for Windows).…”

Section: Animal Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has been generally used to treat hyperlipidemia for decades. Clinical trials with type 2 diabetes patients indicated that BEZ also has beneficial effects on glucose metabolism, although the underlying mechanisms of these effects remain elusive. Even less is known about a potential role for BEZ in treating type 1 diabetes. Here we show that BEZ markedly improves hyperglycemia and glucose and insulin tolerance in mice with streptozotocin (STZ)-induced diabetes, an insulin-deficient mouse model of type 1 diabetes. BEZ treatment of STZ mice significantly suppressed the hepatic expression of genes that are annotated in inflammatory processes, whereas the expression of PPAR and insulin target gene transcripts was increased. Furthermore, BEZ-treated mice also exhibited improved metabolic flexibility as well as an enhanced mitochondrial mass and function in the liver. Finally, we show that the number of pancreatic islets and the area of insulin-positive cells tended to be higher in BEZ-treated mice. Our data suggest that BEZ may improve impaired glucose metabolism by augmenting hepatic mitochondrial performance, suppressing hepatic inflammatory pathways, and improving insulin sensitivity and metabolic flexibility. Thus, BEZ treatment might also be useful for patients with impaired glucose tolerance or diabetes.

show abstract

Section: Animal Studiesmentioning

confidence: 99%

Section: Animal Studiesmentioning

confidence: 99%