Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice

Hu, Zixi; Chen, Jiaojiao; Zhou, Sufang; Yang, Nuo; Duan, Siliang; Zhang, Zhenghua; Su, Jing; He, Jian; Zhang, Zhiyong; Lü, Xiaoling; Zhao, Yongxiang

doi:10.7150/thno.16236

Cited by 62 publications

(33 citation statements)

References 32 publications

(41 reference statements)

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“…In a murine trial of myeloma with administration of a CXCL10-Ig fusion protein, not only an enhancement of antitumor immunity but also a suppression of tumor growth was described (Barash et al 2014). In another study, the combination of CXCL10-loaded nanoparticles and DC/tumor cell fusion vaccine against hepatocellular carcinoma (HCC) effectively inhibited tumor cell proliferation in mice (Hu et al 2017). As CXCL9and CXCL10-mediated tumor infiltration by T-cells is suppressed due to DNA-methylation of the encoding genes, treatment with epigenetic modulating drugs can increase chemokine release and subsequently also effector T cell tumor-infiltration (Peng et al 2015).…”

Section: Role Of Chemokines In Tumor Immunology and In Immunotherapymentioning

confidence: 99%

Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease

Merle

Fischbacher

Liepert

et al. 2019

Immunological Investigations

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In cancer or hematologic disorders, chemokines act as growth-or survival factors, regulating hematopoiesis and angiogenesis, determining metastatic spread and controlling leukocyte infiltration into tumors to inhibit antitumor immune responses. The aim was to quantify the release of CXCL8, −9, −10, CCL2, −5, and IL-12 in AML/ MDS-pts' serum by cytometric bead array and to correlate data with clinical subtypes and courses. Minimal differences in serum-levels subdivided into various groups (e.g. age groups, FAB-types, blastproportions, cytogenetic-risk-groups) were seen, but higher release of CXCL8, −9, −10 and lower release of CCL2 and −5 tendentially correlated with more favorable subtypes (<50 years of age, <80% blasts in PB). Comparing different stages of the disease higher CCL5-release in persisting disease and a significantly higher CCL2release at relapse were found compared to first diagnosispointing to a change of 'disease activity' on a chemokine level. Correlations with later on achieved response to immunotherapy and occurrence of GVHD were seen: Higher values of CXCL8, −9, −10 and CCL2 and lower CCL5-values correlated with achieved response to immunotherapy. Predictive cut-off-values were evaluated separating the groups in 'responders' and 'non-responders'. Higher levels of CCL2 and −5 but lower levels of CXCL8, −9, −10 correlated with occurrence of GVHD. We conclude, that in AML-pts' serum higher values of CXCL8, −9, −10 and lower values of CCL5 and in part of CCL2 correlate with more favorable subtypes and improved antitumor'-reactive function. This knowledge can contribute to develop immune-modifying strategies that promote antileukemic adaptive immune responses.

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Section: Role Of Chemokines In Tumor Immunology and In Immunotherapymentioning

confidence: 99%

Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease

Merle

Fischbacher

Liepert

et al. 2019

Immunological Investigations

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“…Norcantharidin could induce apoptosis and inhibit proliferation of Tregs and its mechanism is probably associated with Vaccine therapy is an important and effective approach in treating many malignancies. 19,20 Several published studies have shown that GM-CSF-modified cell vaccines could induce effective antitumor immunity. 19,21 Granulocyte macrophage colony-stimulating factor plays a major role in maturation of DCs and activation of CD4 + and CD8 + T cells.…”

Section: Discussionmentioning

confidence: 99%

Norcantharidin enhances antitumor immunity of GM‐CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells

Zhang

Shi

et al. 2018

Cancer Science

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Norcantharidin (NCTD) is a promising antitumor drug with low toxicity. It was reported to be able to regulate immunity, but the mechanism is not yet clear. Here we explored whether NCTD could enhance the antitumor immunity induced by prostate cancer cell vaccine. The results of the in vitro study showed that NCTD induced apoptosis and inhibited proliferation of regulatory T cells (Tregs). Mechanistic research showed that NCTD inhibited Akt activation and activated FOXO1 transcription, resulting in a pro‐apoptotic effect. The results of the in vivo study showed that more tumor‐infiltrating Tregs existed within peripheral blood and tumor tissue after treatment with the vaccine. Adding NCTD to vaccine treatment could decrease the number of tumor‐infiltrating Tregs and increase the number of CD4+ and CD8+ T cells. Combination therapy with NCTD and vaccine was more effective in inhibiting tumor growth than the vaccine alone. In general, this is the first report that NCTD could induce apoptosis of Tregs and enhance the vaccine‐induced immunity.

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“…pH-sensitive microneedle chemically coated with inactivated polio vaccine and N-trimethyl chitosan chloride via electrostatic interactions for dermal vaccination in rats [127] Glycol chitosan nanoparticles for mucosal intranasal administration of hepatitis B vaccine [128] Folate-chitosan/ interferon-induced protein-10 gene nanoparticles and DC/tumor fusion vaccine enhanced anti-hepatocellular carcinoma effects in mice [129] Drug Delivery…”

Section: Tissue Engineeringmentioning

confidence: 99%

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

Casadidio

Peregrina

Gigliobianco

et al. 2019

Preprint

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Huge amounts of chitin and chitosans can be found in the biosphere as important constituent of the exoskeleton of many organisms, as well as waste by worldwide seafood companies. Nowadays, politicians, environmentalists, and industrialists encouraged the use of these marine polysaccharides as renewable source, particularly when developed by alternative eco-friendly processes, especially in the production of regular cosmetics. The aim of this review is to outline the physicochemical and biological properties and the different bioextraction methods of chitin and chitosans sources, focusing on enzymatic deproteinization, bacteria fermentation, and enzymatic deacetylation methods. Thanks to their biodegradability, non-toxicity, biocompatibility, and bioactivity, the application of these marine polymers is widely used in the contemporary manufacturing of biomedical and pharmaceutical products. In the end, advanced cosmetic products based on chitin and chitosans are presented, analyzing different therapeutic aspects about skin, hair, nail, and oral care. The innovative formulations described can be considered as excellent solutions regarding problems in the various body anatomical sectors.

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Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice

Cited by 62 publications

References 32 publications

Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease

Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease

Norcantharidin enhances antitumor immunity of GM‐CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

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