Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Zhang, Yudi; Kinast, Volker; Sheldon, Julie; Frericks, Nicola; Todt, Daniel; Zimmer, Matthias M.; Caliskan, Neva; Brown, Richard J. P.; Steinmann, Eike; Pietschmann, Thomas

doi:10.1128/spectrum.01284-23

Cited by 1 publication

(1 citation statement)

References 53 publications

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“…This indicated that zinc-finger domain might play important role in SHFL location. Recently, Shfl was also reported to own the anti-HCV ability in mouse model ( Zhang et al, 2023 ). These studies suggest SHFL could effectively inhibit viruses in flavivirus family.…”

Section: The Inhibiting Function Of Shfl To Rna Virusesmentioning

confidence: 99%

Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review

Wang,

Zhang

2023

Front. Microbiol.

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Various interferon (IFN)-stimulated genes (ISGs), expressed via Janus kinase–signal transducer and activator of transcription (JAK-STAT) signaling pathway-stimulated IFNs to increase antiviral effects or regulate immune response, perform different roles in virus-infected cells. In recent years, a novel ISG, SHFL, which is located in the genomic region 19p13.2 and comprises two isoforms, has been studied as a virus-inhibiting agent. Studies have shown that SHFL suppressive effects on human immunodeficiency virus-1 (HIV), Zika virus (ZIKV), dengue virus (DENV), hepatitis C virus (HCV), Japanese encephalitis virus (JEV), porcine epidemic diarrhea virus (PEDV), Human enterovirus A71 (EV-A71) and Kaposi’s sarcoma-associated herpes virus (KSHV). SHFL interacts with various viral and host molecules to inhibit viral life circle and activities, such as replication, translation, and ribosomal frameshifting, or regulates host pathways to degrade viral proteins. In this review, we summarized the functional features of SHFL to provide insights to underlying mechanisms of the antiviral effects of SHFL and explored its potential function.

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Section: The Inhibiting Function Of Shfl To Rna Virusesmentioning

confidence: 99%

Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review

Wang,

Zhang

2023

Front. Microbiol.

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show abstract

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Abstract: Viruses have evolved ways to evade or blunt innate cellular antiviral mechanisms within their cognate host species. However, these adaptations may fail when viruses infect new species and can therefore limit cross-species transmission.

Cited by 1 publication

References 53 publications

Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review

Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review

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