Moving forward in the new year

Poh, Kian‐Keong

doi:10.11622/smedj.2017001

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…In Malaysia, ~740 new cases of leukemia are diagnosed annually,2 of which CML accounts for 15%. Since the first TKI, imatinib, was launched in Malaysia in 2003, the overall survival rate of CML patients has reached 94.3% at 10 years 3. It is estimated that about 1,500 CML patients are seeking treatment in Malaysia.…”

Section: Introductionmentioning

confidence: 99%

“…Since the first TKI, imatinib, was launched in Malaysia in 2003, the overall survival rate of CML patients has reached 94.3% at 10 years. 3 It is estimated that about 1,500 CML patients are seeking treatment in Malaysia. Although the possibility of stopping TKI therapy in CML patients who have achieved deep molecular responses is a topic of active debate and investigation, 4 , 5 lifelong treatment remains the current standard of care.…”

Section: Introductionmentioning

confidence: 99%

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Medication-related issues associated with adherence to long-term tyrosine kinase inhibitors for controlling chronic myeloid leukemia: a qualitative study

Tan¹,

Beng²,

Chen

et al. 2017

PPA

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PurposePoor adherence to tyrosine kinase inhibitors (TKIs) could compromise the control of chronic myeloid leukemia (CML) and contributes to poorer survival. Little is known about how medication-related issues affect CML patients’ adherence to TKI therapy in Malaysia. This qualitative study aimed to explore these issues.Patients and methodsIndividual face-to-face, semistructured interviews were conducted at the hematology outpatient clinics of two medical centers in Malaysia from August 2015 to January 2016. CML patients aged ≥18 years who were prescribed a TKI were invited to participate in the study. Interviews were audio-recorded, transcribed verbatim, and thematically analyzed.ResultsFour themes were identified from 18 interviews: 1) concerns about adverse reactions to TKIs, 2) personal beliefs regarding the use of TKIs, 3) mismanagement of TKIs in daily lives, and 4) financial burden in accessing treatment. Participants skipped their TKIs due to ineffective emesis control measures and perceived wastage of medication from vomiting. Participants also modified their TKI therapy due to fear of potential harm from long-term use, and stopped taking their TKIs based on belief in curative claims of traditional medicines and misconception about therapeutic effects of TKIs. Difficulty in integrating the dosing requirements of TKIs into daily lives led to unintentional skipping of doses, as well as the risk of toxicities from inappropriate dosing intervals or food interactions. Furthermore, financial constraints also resulted in delayed initiation of TKIs, missed clinic appointments, and treatment interruptions.ConclusionMalaysian CML patients encountered a range of medication-related issues leading to a complex pattern of nonadherence to TKI therapy. Further studies should investigate whether regular contact with patients to improve understanding of treatment rationale, to elicit and address patients’ concerns about adverse reactions, and to empower patients with skills to self-manage their medications might promote better adherence to TKIs and improve CML patients’ outcome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Medication-related issues associated with adherence to long-term tyrosine kinase inhibitors for controlling chronic myeloid leukemia: a qualitative study

Tan¹,

Beng²,

Chen

et al. 2017

PPA

View full text Add to dashboard Cite

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“…To execute this strategy, we have developed a presence on these platforms: Twitter, Facebook and LinkedIn. The types of posts will include: (a) posts that summarise new articles and provide links to the full articles; (b) journal announcements on events, new issues and calls for paper; (c) infographics and Singapore Medical Journal in the age of social media • Key sources of research works • Interested in keeping tabs on the latest research findings in their fields • Keen to promote their research to a wider audience, enhancing visibility of their works and profile (5) • Keen to discuss their ideas and research in-depth verbally • Keen to engage key opinion leaders in discussion and consultation • Interested in becoming thought leaders and influence their own research communities • May be more inclined to submit articles to a journal that can offer them a platform that fulfils the above We are excited by the prospects of enhancing the reach and functions of the journal, and look forward to interacting with you on Twitter, Facebook and LinkedIn. We hope you will support the journal by following us on these social media platforms, and sharing, forwarding and discussing published articles on the platforms.…”

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confidence: 99%

Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore

Khoo¹,

Hui²,

Mohideen³

et al. 2021

smedj

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INTRODUCTION Chest radiographs (CXRs) are widely used for the screening and management of COVID-19. This article describes the radiographic features of COVID-19 based on an initial national cohort of patients. METHODS This is a retrospective review of swab-positive patients with COVID-19 who were admitted to four different hospitals in Singapore between 22 January and 9 March 2020. Initial and follow-up CXRs were reviewed by three experienced radiologists to identify the predominant pattern and distribution of lung parenchymal abnormalities. RESULTS In total, 347 CXRs of 96 patients were reviewed. Initial CXRs were abnormal in 41 (42.7%) out of 96 patients. The mean time from onset of symptoms to CXR abnormality was 5.3 ± 4.7 days. The predominant pattern of lung abnormality was ground-glass opacity on initial CXRs (51.2%) and consolidation on follow-up CXRs (51.0%). Multifocal bilateral abnormalities in mixed central and peripheral distribution were observed in 63.4% and 59.2% of abnormal initial and follow-up CXRs, respectively. The lower zones were involved in 90.2% of initial CXRs and 93.9% of follow-up CXRs. CONCLUSION In a cohort of swab-positive patients, including those identified from contact tracing, we found a lower incidence of CXR abnormalities than was previously reported. The most common pattern was ground-glass opacity or consolidation, but mixed central and peripheral involvement was more common than peripheral involvement alone.

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“…To execute this strategy, we have developed a presence on these platforms: Twitter, Facebook and LinkedIn. The types of posts will include: (a) posts that summarise new articles and provide links to the full articles; (b) journal announcements on events, new issues and calls for paper; (c) infographics and • Key sources of research works • Interested in keeping tabs on the latest research findings in their fields • Keen to promote their research to a wider audience, enhancing visibility of their works and profile (5) • Keen to discuss their ideas and research in-depth verbally • Keen to engage key opinion leaders in discussion and consultation • Interested in becoming thought leaders and influence their own research communities • May be more inclined to submit articles to a journal that can offer them a platform that fulfils the above (5)…”

mentioning

confidence: 99%