Moxa smoke: Is it a beneficial or hazardous factor for infertility? A preclinical study on sperm parameters and sex hormones in male rats

Wang, Lei; Han, Li; Liu, Ping; Yang, Jia; Cui, Yingxue; Bai, Hua; Liu, Juntian; Huang, Yuhai; Huang, Jian; Huang, Chang; Zhao, Baixiao

doi:10.1016/j.eujim.2015.10.005

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The methanol extract of moxa smoke has the functions of antioxidation and eliminates free radicals [ 28 ]. Another study demonstrated that moxa smoke can improve sperm concentration and promote sperm movement in rats [ 29 ]. Although it was suggested that the toxic compounds in moxa smoke were harmful to the human heart, liver, and kidneys, low and middle concentrations had no effects.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Moxibustion plays an important role in the prevention and treatment of diseases and the promotion of human health. In this study, the components in moxa smoke from Jiangxi Poai Biotechnology Co., Ltd., namely, Qing moxa sticks, were absorbed by five solvents (cyclohexane, ethyl acetate, n-butanol, anhydrous ethanol, and water) and identified by gas chromatography-mass spectrometry. The identification results of the smoke from the Qing moxa sticks that was absorbed in liquid are as follows: a total of 294 compounds were identified, including 139 in cyclohexane, 145 in ethyl acetate, 60 in n-butanol, 89 in anhydrous ethanol, and 77 in water, and of those, 112 toxic compounds were identified. Furthermore, Ingenuity Pathway Analysis software and the PubChem database were successfully applied to analyze the toxic compounds. There were 812 target proteins related to the toxic components, 25 molecular networks, and 54 biological pathways. The results showed that the toxic compounds of moxa smoke may have some side effects on the heart, liver, and kidney of humans. This study revealed that the components of moxa smoke are complex and diverse. Due to the findings of toxic compounds in moxa smoke, we recommend that moxibustion rooms should be equipped with ventilation equipment or enough artificial ventilation to ensure the health of patients and practitioners.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Our previous research found that electroacupuncture exerted therapeutic effects on asthenozoospermia by enhancing sperm viability and motility in rats (Jin et al, 2017). MS was proved to be effective in improving the reproductive function of male rats, and the low concentration of MS seemed to be superior to the high concentration of MS in terms of improving sperm parameters, testis index, and serum sex hormones (Wang et al, 2016). In this context, we hypothesized that MS constituted an effective factor of moxibustion therapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of moxa smoke on sperm parameters and oxidative stress in rats with asthenozoospermia

Liu

Xing

et al. 2022

The Anatomical Record

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Asthenozoospermia is a leading cause of male infertility, characterized by reduced sperm motility. In this study, we determined sperm motility and the activities of antioxidant enzymes and oxidation products in the testis of rats with ornidazole (ORN)‐induced asthenozoospermia and further examined and compared the differential effects of moxa smoke (MS) and cigarette smoke (CS) on sperm motility and oxidative stress (OS) of asthenozoospermic rats. The smoke intervention was initiated 11 days after intragastric administration of ORN, followed by the examination of testis index, sperm parameters, OS‐related gene levels, and testicular histopathology. Sperm motility and antioxidant enzyme activities, as well as oxidation products significantly decreased in ORN‐induced rats compared with MS‐treated rats (p < .05–.001). MS treatment restored the reduced sperm motility and activities of glutathione peroxidase, superoxide dismutase, and catalase, but increased the malondialdehyde and nitric oxide synthetase levels in ORN‐induced rats (p < .05–.001). Also, the histopathological changes in the testis of ORN‐induced rats were improved by MS treatment. The study highlighted that MS was an effective factor in moxibustion therapy, which notably improved the sperm motility of asthenozoospermic rats by inhibiting OS in the reproductive system.

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Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

Han

Liu

Liu³

et al. 2018

Journal of Traditional Chinese Medicine

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Moxa smoke: Is it a beneficial or hazardous factor for infertility? A preclinical study on sperm parameters and sex hormones in male rats

Cited by 5 publications

References 21 publications

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Effect of moxa smoke on sperm parameters and oxidative stress in rats with asthenozoospermia

Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats

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