Mp01-07 prostacare: Water Electrolysis System for the Treatment of Benign Prostate Hyperplasia

Abstract

INTRODUCTION AND OBJECTIVES: A thermo-sensitive antiadhesive with a property of sol-gel transition was manufactured by a physical mixture of Poloxamer, Chitosan and Gelatin. Poloxamerbased thermo-sensitive sol-gel has been developed to reduce the incidence of postoperative adhesion formation. The purpose of this study was to evaluate the effect of poloxamer-based thermo-sensitive sol-gel instillation after transurethral resection of the prostate (TURP) on preventing urethral stricture.METHODS: A total of 198 patients underwent TURP for benign prostatic hyperplasia.Recruited patients were randomly divided into two groups: Groups A and B. Patients in group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation, and patients in the group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS)/Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), peak urine ï:‚ow rate (Qmax), voided volume, postvoid residual volume (PVR) and cystoscopy.RESULTS: Among 198 initial participants, 80 patients in group A and 83 patients in group B had completed theexperiment. There were no significant difference in IPSS/QoL, and OAB-q. However, Qmax (mL/ sec) showed significant difference between group A and group B (18.92AE9.98 vs. 15.58AE9.24, p[0.028) in 24 weeks after surgery. Also, result of PVR (mL) 24 weeks after surgery had significant difference between group A and group B (17.81AE28.33 vs. 30.12AE51.92, p[0.061). By Cystoscopy, urethral stricture after TURP was seen in 2 of 80 subjects in group A and 10 of 83 subjects in group B (p[0.023).CONCLUSIONS: Poloxamer-based thermo-sensitive sol-gel instillation after TURP decreased the incidence of urethral stricture.