Mp17-16 a Urine-Based Dna Methylation Test to Monitor Response to Neoadjuvant Chemotherapy in Bladder Cancer

Abstract

disease, and 5 died of disease. Within the same period, other histological variants were found in 48 cases, including 13 micropapillary and 14 plasmacytoid variant cases. Compared to LCV and other variants, LCV had significantly worse recurrence-free survival (HR [ 1.82; 95% CI 1.03e4.73; p [ 0.043) and cancer-specific survival (HR [ 3.40; 95% CI 1.10e10.77; p [ 0.032). On IHCS, adipophilin was positive for cytoplasm of LCV but cytoplasmic vacuoles themselves were negative. In a special case, we firstly demonstrated lipid component in cytoplasmic vacuoles of LCV by oil red O staining using frozen sections. The type of lipid dyed by oil red O staining was triglyceride, and it was proved that cytoplasmic vacuoles in LCV were triglycerides.CONCLUSIONS: Although LCV has been thought to be rare, the incidence of this variant does not seem to be extremely low based on the present study. Patients with this variant had high recurrence rates and poor prognosis. Also, this is the first report in the literature that the component of the cytoplasmic vacuoles of LCV is lipid directly.