Mp53-15 Local Staging With Multi-Parametric Mri Prior to Radical Prostatectomy: Diagnostic Accuracy and Evaluation of a Radiologic Learning Curve in a Multicenter, Real-Life Clinical Setting

Abstract

Therefore, to determine the risk of disease and thus trying to Stratify it is essential in these tumors. Thus, various tools for predicting postoperative evolution have been developed and subsequently validated in several studies. In 2011, the University of California, San Francisco proposed the Cancer of the Prostate Risk Assessment Score (CAPRA-S), which uses clinical and pathological information in order to predict progression of an easy and reasonable way. The aim of the present study is to perform external validation to determine whether the Cancer of the Prostate Risk Assessment score (CAPRA-S) predicts biochemical recurrence, metastasis and death for prostate cancer after radical prostatectomy in Latin American population.METHODS: 216 patients were studied. Probability of score to predict biochemical recurrence after radical prostatectomy was analyzed by Cox proportional method. Biochemical recurrence, metastasis and cancer specific free survival was determinate by Kaplan method. Exactitude of CAPRA-S score to predict biochemical recurrence, metastasis and death by prostate cancer was made in accordance with Harrells concordance index.RESULTS: median follow up was 74 months. Biochemical recurrence index increase proportionally with the increment of CAPRA-S score. In the stratification of patients in low, intermediate or high risk, biochemical recurrence free rate were 85%, 54% and 4% respectively. Concordance index (C-Index) to biochemical progression, metastasis and death by prostate cance were 0.85, 0.90 and 0.90 respectively.CONCLUSIONS: CAPRA-S score is an easily applicable tool and had high predictive exactitude to determinate biochemical recurrence, metastasis and death by prostate cancer in our population. Concordance Index in these variables was higher than 0.85.