2024
DOI: 10.1093/bib/bbae598
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MPA-MutPred: a novel strategy for accurately predicting the binding affinity change upon mutation in membrane protein complexes

Fathima Ridha,
M Michael Gromiha

Abstract: Mutations in the interface of membrane protein (MP) complexes are key contributors to a broad spectrum of human diseases, primarily due to changes in their binding affinities. While various methods exist for predicting the mutation-induced changes in binding affinity (ΔΔG) in protein–protein complexes, none are specific to MP complexes. This study proposes a novel strategy for ΔΔG prediction in MP complexes, which combines linear and nonlinear models, to obtain a more robust model with improved prediction accu… Show more

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