Mpox (Monkeypox) Infection During Pregnancy

Abstract

Pregnant individuals are susceptible to maternal mpox (monkeypox) infection and are eligible for treatment. Although transplacental transmission of mpox is possible, this case did not result in fetal infection.

Epidemiological and Clinical Characteristics of Mpox in Cisgender and Transgender Women and Non-Binary Individuals Assigned to the Female Sex at Birth: A Comprehensive, Critical Global Perspective

“…Out of the 957 unique items, 928 were discarded, based on the title and/or abstract screening. Out of the twenty-nine studies screened for their full text, six studies were excluded with reason, while the remaining twenty-three studies [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] from various locations, including Argentina, Brazil, Colombia, Nigeria, Europe, Vietnam, and the USA, were retained and overviewed. More in detail, six cohort studies [ 28 , 29 , 30 , 31 , 32 , 33 ] were retrieved and synthesized, along with fourteen clinical case reports [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ], two case series [ 48 , 49 ], and one case series review [ 50 ] ( Figure 1 ).…”

“…Out of the twenty-nine studies screened for their full text, six studies were excluded with reason, while the remaining twenty-three studies [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] from various locations, including Argentina, Brazil, Colombia, Nigeria, Europe, Vietnam, and the USA, were retained and overviewed. More in detail, six cohort studies [ 28 , 29 , 30 , 31 , 32 , 33 ] were retrieved and synthesized, along with fourteen clinical case reports [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ], two case series [ 48 , 49 ], and one case series review [ 50 ] ( Figure 1 ). The major features of these studies are presented in Table 2 .…”

“…Sampson et al [ 47 ] presented a case of a 20-year-old pregnant woman at 31 weeks of gestation, with a history of sexually transmitted infections but no chronic conditions. She sought medical attention due to vaginal discharge, bleeding, painful urination, and decreased fetal movements for two weeks.…”

Mpox and pregnancy: A call for inclusion of pregnant patients in future research

“…In this meta-analysis there were no reports of maternal deaths [ 3 ]. There is a single case of mpox infection during pregnancy published during the current outbreak, which resulted in the birth of a healthy neonate [ 4 ].…”

“…Pregnant subjects were excluded from the original pharmacokinetic studies of tecovirimat. In one recent publication of tecovirimat treatment during the third trimester, the neonate was born healthy without complications [ 4 ]. In addition, no adverse events were observed in supratherapeutic doses given in animal studies.…”