2012
DOI: 10.1038/embor.2012.93
|View full text |Cite
|
Sign up to set email alerts
|

Mps1 promotes rapid centromere accumulation of Aurora B

Abstract: Aurora B localization to mitotic centromeres, which is required for proper chromosome alignment during mitosis, relies on Haspin‐dependent histone H3 phosphorylation and on Bub1‐dependent histone H2A phosphorylation—which interacts with Borealin through a Shugoshin (Sgo) intermediate. We demonstrate that Mps1 stimulates the latter recruitment axis. Mps1 activity enhances H2A‐T120ph and is critical for Sgo1 recruitment to centromeres, thereby promoting Aurora B centromere recruitment in early mitosis. Important… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
78
0
2

Year Published

2013
2013
2020
2020

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 80 publications
(89 citation statements)
references
References 28 publications
6
78
0
2
Order By: Relevance
“…Our results are consistent with a feedback mechanism between Mps1 and Aurora-B rather than a strictly linear pathway in which one kinase is upstream of the other (Jelluma et al, 2008b;Hewitt et al, 2010;Santaguida et al, 2010). Significantly, inhibition of Mps1 did not reduce phosphorylated Ser331 at kinetochores (Jelluma et al, 2008b;Santaguida et al, 2010;van der Waal et al, 2012b).…”
Section: Chk1 Prevents Merotelic Attachments 1241supporting
confidence: 79%
“…Our results are consistent with a feedback mechanism between Mps1 and Aurora-B rather than a strictly linear pathway in which one kinase is upstream of the other (Jelluma et al, 2008b;Hewitt et al, 2010;Santaguida et al, 2010). Significantly, inhibition of Mps1 did not reduce phosphorylated Ser331 at kinetochores (Jelluma et al, 2008b;Santaguida et al, 2010;van der Waal et al, 2012b).…”
Section: Chk1 Prevents Merotelic Attachments 1241supporting
confidence: 79%
“…Although Mps1 activates aurora B (Jelluma et al, 2008;van der Waal et al, 2012), it also acts downstream of aurora B Saurin et al, 2011). In addition, live cell imaging revealed that nocodazole-treated cells were held at mitosis, while few cells underwent mitotic exit and cell death ( Figure 6D).…”
Section: Bjp M Choi Et Almentioning
confidence: 98%
“…Aurora B is also critical for the checkpoint under certain circumstances, such as a lack of tension. Although this may largely be a consequence of the destabilizing function in yeast 141 , human Aurora B appears to also be important for loading or stabilizing Mps1 on kinetochores 115-118,142 .…”
Section: Box 1: Conserved Checkpoint Kinasesmentioning
confidence: 99%