MPV in Uncontrolled &amp; Controlled Diabetics- Its Role as an Indicator of Vascular Complication

Radha, Rajesh Kanna Nandagopal; Selvam, D.

doi:10.7860/jcdr/2016/21499.8353

Cited by 16 publications

(15 citation statements)

References 25 publications

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“…[20,23] Research is also being carried out in the diabetic population to find a correlation between increased MPV and the presence of microvascular complications with many studies suggesting a strong association between the two. [12,24] The current study is in corroboration with the same and is in agreement with the results of other researchers, [3,18,25,26] wherein there is a significantly higher MPV among the diabetic patients with microvascular complications when compared to those without the same (mean MPV in diabetics with microvascular complications -10.66±0.69 fl, mean MPV in diabetics without microvascular complications -10.09±0.69 fl, P value=0.024). This finding indicates that chronic hyperglycaemia and increased MPV may have a crucial role to play in the pathogenesis of microvascular complications associated with DM.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Mean Platelet Volume in Diabetes Mellitus and Its Role in Microvascular Complications

Prasad

Prakash

2018

APALM

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Background: Diabetes mellitus(DM) is a metabolic disorder characterised by hyperglycaemia. The hyperglycemia results in altered platelet function as reflected in the platelet indices (mean platelet volume-MPV, platelet distribution width and plateletcrit). Altered platelet function has also been implicated in the occurrence of diabetic vascular complications. Evaluation of platelet indices may serve to provide an insight into the pathogenesis of DM as well as possibly evaluate the risk of progression of the disease. The aim of the current study was to evaluate the MPV in patients with DM and compare it with a non-diabetic control group. We also attempted to determine the association between MPV and microvascular complications within the diabetic cohort. Methods: The study was carried out on patients with diabetes mellitus, attending the medicine outpatient department. Relevant history was taken and fasting blood glucose and hematological parameters (platelet indices and complete blood counts) were assessed as a part of the routine investigations requested by the physician itself. A total of 320 diabetics were screened for the study. After applying exclusion criteria, 52 diabetics were included in the study. We also included 62 non-diabetic, age and sex matched controls in the study. Statistical analysis was performed. Results and Conclusion: MPV levels were significantly higher in diabetic patients when compared to non-diabetic controls. Also, within the diabetic group, MPV values were significantly higher in diabetics with microvascular complications (24 patients) as opposed to the ones without. MPV is a simple, convenient and cost-effective routine hematological investigation which plays a significant role in the pathogenesis of diabetes mellitus and may serve as an useful prognostic marker to herald the onset of microvascular complications in the diabetic population.

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Section: Discussionsupporting

confidence: 92%

Evaluation of Mean Platelet Volume in Diabetes Mellitus and Its Role in Microvascular Complications

Prasad

Prakash

2018

APALM

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“…Of these 48 articles, 27 came from China [ 22 , 30 , 34 , 36 , 37 , 41 , 43–46 , 48 , 49 , 55–60 , 64 , 65 , 67 , 68 , 70–73 ], 16 from Turkey [ 21 , 23 , 29 , 31 , 35 , 38 , 40 , 42 , 47 , 50–54 , 61 , 69 ], 3 from India [ 32 , 63 , 39 ], 1 from Greece [ 62 ] and 1 from Kazakhstan [ 33 ]. Amongst these studies, 21 reported NLR (9 enrolled patients with DR, 12 enrolled patients with DN) [ 21 , 23 , 31 , 32 , 34 , 35 , 38 , 41–43 , 45 , 47 , 50–54 , 56–60 , 62 , 63 , 65 , 67–69 , 71–73 ], 33 reported the data of MPV (23 enrolled patients with DR, 10 enrolled patients with DN) [ 22 , 29 , 30 , 33 , 36–40 , 44 , 46 , 48–50 , 55 , 61 , 64 , 66 , 70 , 73 ], and 12 reported PDW (12 enrolled patients with DR, 3 enrolled patients with DN) [ 21 , 23 , …”

Section: Resultsmentioning

confidence: 99%

“…There were 23 articles with 3437 patients, which had data of MPV for DR [ 21 , 23 , 32 , 35 , 50–54 , 56–60 , 62 , 63 , 65 , 67–69 , 71–73 ]. Random-effects model was used to pool the data because of the significant heterogeneity amongst the included studies ( I 2 = 94.1; P <0.01).…”

Section: Resultsmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

Liu

Li³

et al. 2018

Bioscience Reports

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The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, Embase, Web of Science, and CNKI up to 1 December 2017. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared with patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV, and PDW were higher in patients with DR (SMD = 0.77; 95% CI: 0.49–1.05; P<0.001; SMD = 0.68; 95% CI: 0.36–0.99; P<0.001; SMD = 0.52; 95% CI: 0.28–0.76; P<0.01). Compared with patients with T2DM and without DN, NLR, MPV, and PDW were higher in patients with DN (SMD = 0.63; 95% CI: 0.43–0.83; P<0.001; SMD = 0.81; 95% CI: 0.36–1.25; P<0.001; SMD = 0.70; 95% CI: 0.50–0.90; P<0.001). We also found that MPV was strongly associated with the severity of DR, and NLR was closely related to the degree of DN. Our findings indicated that NLR, MPV, and PDW could be recommended as inexpensive diagnostic biomarkers for DN and DR. However, considering several limitations in the present study, further high-quality clinical studies should be performed to investigate the relationship of NLR, MPV, and PDW to DN and DR.

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“…Mean platelet volume was found to be higher in patients with uncontrolled DM than those with controlled disease and healthy nondiabetic persons (Radha & Selvam, ).…”

Section: Introductionmentioning

confidence: 99%

Platelet Indices as a marker for early prediction of erectile dysfunction in diabetic patients

et al. 2018

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Erectile dysfunction is one of the major concerns in diabetic patients. Platelet Indices including mean platelet volume, platelet count and platelet distribution width are important biomarkers for platelet activation and pathophysiology of atherothrombosis. Measurement of Platelet Indices may early predict erectile dysfunction in diabetic men. This study aimed to measure Platelet Indices in diabetic patients with erectile dysfunction and to correlate between them and erectile dysfunction especially of vasculogenic type. The study included 30 diabetic patients with diagnosed erectile dysfunction and 20 normal males as a control. Each patient was evaluated by history, International Index of Erectile Function-5, general and local examination, HbA1c, pharmaco-penile duplex ultrasonography and blood sample to measure Platelet Indices. Platelet distribution width and mean platelet volume were significantly higher in patients than controls (p < 0.001). Their levels were significantly higher in vasculogenic erectile dysfunction than other types (p < 0.001). No statistically significant association regards the platelet count (p > 0.05). We concluded that Platelet Indices are high in diabetic patients with erectile dysfunction especially those with vasculogenic aetiology. They can predict erectile dysfunction in diabetic men early, and so they may be considered as cheap, available and useful biomarker for early diagnosis of vasculogenic erectile dysfunction in diabetic patients. K E Y W O R D Sdiabetes, erectile dysfunction, Platelet Indices

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MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication

Cited by 16 publications

References 25 publications

Evaluation of Mean Platelet Volume in Diabetes Mellitus and Its Role in Microvascular Complications

Evaluation of Mean Platelet Volume in Diabetes Mellitus and Its Role in Microvascular Complications

The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

Platelet Indices as a marker for early prediction of erectile dysfunction in diabetic patients

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