MR Contrast Agents for Liver Imaging: What, When, How

Gandhi, Sunil; Brown, Michèle A.; Wong, James; Aguirre, Diego A.; Sirlin, Claude B.

doi:10.1148/rg.266065014

Cited by 149 publications

(105 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The introduction of breath-hold sequences with gadolinium chelates have facilitated the development of dynamic contrast-enhanced imaging of the liver in clinical practice. 27,28 In turn, a number of studies have described changes in hepatic parenchyma texture after contrast-enhanced imaging by MRI (Table 1). [27][28][29][30][31][32][33][34][35] Early patchy enhancement may correlate with increased numbers of macrophages and necroinflammation on liver histology.…”

Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

et al. 2008

View full text Add to dashboard Cite

Chronic liver disease and cirrhosis remains a major public health problem worldwide. While the majority of complications from chronic liver disease result from progressive hepatic fibrosis, the available diagnostic tests used in clinical practice are not sensitive or specific enough to detect occult liver injury at early or intermediate stages. While liver biopsy can stage the extent of fibrosis at diagnosis, its utility as a tool for longitudinal monitoring will be limited at the population level. To date, a number of methods including serum marker panels and ultrasound-based transient elastrography have been proposed for the non-invasive identification of hepatic fibrosis. Novel techniques including magnetic resonance (MR) spectroscopy, diffusion weighted MR, and MR elastography have also emerged for detecting fibrosis. In contrast to other non-invasive methods, MR imaging holds the promise of providing functional and biological information about hepatic pathophysiology as it relates to the natural history and future treatment of hepatic fibrosis. (HEPATOLOGY 2008;47:332-342.)

show abstract

Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Dezavantajları ise rekonstrüksiyon artefaktları ve sinyal-gürültü oranında düşmedir. 12 SENSE tekniğinin esas fonksiyonu hızlı görüntüle-medir. Redüksiyon zamanının azalması görüntü kalitesini kötüleştiren solunum hareketinden ve barsak peristaltizminden kaynaklanan artefaktları azaltıp, görüntü kalitesini arttırır.…”

Section: Discussionunclassified

“…SENSE tekniği her tip puls sekansı ile birlikte kullanılan oldukça esnek bir yöntemdir. 11,12 Hızlı T2A sekanslar, fokal karaciğer lezyonlarının saptanması ve karakterizasyonunda önemli bir role sahiptir. Bu çalışmada SENSE tekniği kullanılarak inceleme süresi önemli ölçüde kısaltılmış (10s), SPIR SENSE T2A, SENSE T2A, TSE T2A sekans ve dinamik kontrastlı T1A görüntüler arasındaki lezyon saptama duyarlılığı karşılaştırıl-mıştır.…”

Section: Discussionunclassified

See 1 more Smart Citation

Comparison of T2-SENSE, Turbo Spin Echo T2-and T1-weighted MR Sequences for Detection of Liver Lesions

Değirmenci¹,

Çalışkan²,

Kara³

2011

Sakarya Med J

View full text Add to dashboard Cite

ÖzetAmaç: Bu çalışmada karaciğer kitlelerinin saptanmasında çok hızlı sensitivity encoding (SENSE) T2 ağırlıklı (T2A), turbo spin eko (TSE) T2A ve T1 ağırlıklı (T1A), manyetik rezonans görüntüleme (MRG) sekanslarının karşılaştırılması amaçlanmaktadır. Gereç ve Yöntem: Bilinen karaciğer kitlesi olan veya yeni tespit edilen toplam 30 hasta çalışmamıza dahil edildi. Tüm hastalara solunum tetiklemeli SENSE T2A, yağ baskılı, selective presaturation invertion recovery (SPIR) SENSE T2A, nefes tutmalı TSE T2A ve nefes tutmalı dinamik kontrastlı 3 boyutlu (3B) T1 fast field echo (FFE) sekansları uygulandı. Saptanan kitlelerin, sayı, boyut, kenar ve sinyal özellikleri değerlendirilip buna göre gruplar oluşturuldu. T2A sekanslarda lezyonlar kenar özelliklerine göre silik ve keskin konturlu, sinyal özelliklerine göre ise hafif, orta ve belirgin hiperintens olarak gruplara ayrıldı. T2A sekanslarda elde edilen lezyon sayıları, T1A sekanslarda elde edilen lezyon sayıları ile karşılaş-tırıldı. Ayrıca T2A sekanslar arasında lezyon sayı ve boyutları açısından karşılaştırma yapıldı. Bulgular: Çalışmamızda yağ baskılı SENSE T2A (SPIR SENSE) sekansta lezyon sayısı en fazla bulundu. Ancak lezyon saptama duyarlılığı açısından istatistiksel olarak T2A sekanslar ile T1A sekanslar arasında anlamlı fark bulunmadı. SPIR SENSE T2A, SENSE T2A ve TSE T2A sekansları arasın-da lezyon boyutu açısından anlamlı istatistiksel fark bulunmadı. Kontur ve sinyal özelliklerine göre yapılan karşılaştırmada T2A sekanslar arasında istatistiksel fark saptanmadı. Sonuç: SENSE T2A çok hızlı sekanslar, özellikle yağ baskılama ile birlikte kullanıldıklarında, karaciğer lezyonlarını saptamada, TSE T2A sekans kadar duyarlıdır. Çok hızlı SENSE T2A sekanslar, TSE T2A sekansların yerine karaciğer görüntülenmesinde kullanılabilecek güvenilir sekanslardır. AbstractObjective: This study aimed to compare ultrafast sensitivity encoding (SENSE) T2-weighted (T2W), turbo spin echo (TSE) T2-W and T1-weighted (T1W) sequences of magnetic resonance imaging (MRI) for detection of liver masses. Materials and Methods: A total of 30 patients with a known or newly detected liver mass were included in the study. All patients underwent respiratory-triggered T2-W SENSE, fat suppressed (SPIR) T2-W SEN-SE, breath-hold TSE T2-weighted and breath-hold dynamic contrastenhanced 3-dimensional (3D) T1-FFE sequences. The detected masses were evaluated for size, margins and signal characteristics, and accordingly the groups were formed. Lesions on T2-W sequences divided into distinct groups as soft and sharp contours according to their edges, and light, medium and hyperintense according to the characteristics of the signal. The number of lesions on T2-W sequences was compared with that on T1-weighted sequences. In addition, the number and size of lesions among T2-weighted sequences were compared. Results: The maximum number of lesions was found in SENSE T2-W fat suppressed (SPIR SENSE) sequences. However, in terms of lesion detection sensitivity, no statistically significant difference was foun...

show abstract

“…These properties may allow for improved tumor imaging. 21 Intravenous contrast-enhanced abdominal imaging is an important screening and diagnostic modality in liver transplant candidates. Given the potential risk for CIN associated with iodinated CT contrast and the effect of renal insufficiency on mortality in patients with cirrhosis, alternate contrast modalities for abdominal imaging need to be examined for this patient population.…”

mentioning

confidence: 99%

Renal safety of intravenous gadolinium‐enhanced magnetic resonance imaging in patients awaiting liver transplantation

Shaffer¹,

Parikh²,

Runge³

et al. 2015

Liver Transpl

View full text Add to dashboard Cite

Renal dysfunction in cirrhosis carries a high morbidity and mortality. Given the potential risk of contrast-induced nephropathy associated with iodinated intravenous contrast used in computed tomography (CT), alternate contrast modalities for abdominal imaging in liver transplant candidates need to be examined. The purpose of this study was to examine the renal safety of magnetic resonance imaging (MRI) with gadolinium in patients awaiting liver transplantation. The study involved a retrospective analysis of 352 patients of abdominal MRI with low-dose gadobenate dimeglumine (MultiHance) (0.05 mmol/kg) in patients with cirrhosis and without renal replacement therapy at a single center during the period from 2007 to 2013. For each case, serum creatinine before and within a few days after the MRI were compared. In addition, the patients were analyzed for the development of nephrogenic systemic fibrosis (NSF), a reported complication of gadolinium in chronic kidney disease. The pre-MRI serum creatinine values ranged from 0.36 to 4.86 mg/dL, with 70 patients (20%) having values 1.5 mg/dL. A comparison of the pre-and post-MRI serum creatinine values did not demonstrate a clinically significant difference (mean change 5 0.017 mg/dL; P 5 0.38), including those patients with a pre-MRI serum creatinine 1.5 mg/ dL. In addition, no cases of NSF were noted. In conclusion, our findings suggest that MRI with low-dose gadobenate dimeglumine (MultiHance) is a nonnephrotoxic imaging modality in liver transplant candidates, and its use can be cautiously expanded to liver transplant candidates with concomitant renal insufficiency.

show abstract

MR Contrast Agents for Liver Imaging: What, When, How

Cited by 149 publications

References 70 publications

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

Comparison of T2-SENSE, Turbo Spin Echo T2-and T1-weighted MR Sequences for Detection of Liver Lesions

Renal safety of intravenous gadolinium‐enhanced magnetic resonance imaging in patients awaiting liver transplantation

Contact Info

Product

Resources

About