MR Spectroscopy and Spectroscopic Imaging for Evaluation of Skeletal Muscle Metabolism: Basics and Applications in Metabolic Diseases

Boesch, Chris

doi:10.1007/174_2013_847

Cited by 1 publication

(3 citation statements)

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“…In particular, 31-phosphorous ( 31 P) MRS was used to study the energy metabolism of muscular tissue since the very beginning of MR examinations in humans when small-bore magnets for studies of the limbs became available. 67,82 Spatial localization was less demanding in these studies. However, high temporal resolution was necessary to follow metabolism during exercise and recovery.…”

Section: P Magnetic Resonance Spectroscopymentioning

confidence: 89%

“…In addition to non-proton MRI, several other advanced imaging techniques have been used to study muscle diseases. Many of these were discussed in recent reviews, 13,15,16,67,68 and therefore the information here is limited to a short summary of the technique and recent advances. The reviews offer more in-depth information.…”

Section: P Magnetic Resonance Spectroscopymentioning

confidence: 99%

“…13,82 Intracellular pH, as well as the MR signal intensity ratios P i :PCr (inorganic phosphate [P i] to phosphocreatine [PCr]) and PDE:PCr (phosphodiester [PDE] to PCr), were reported to increase depending on the stage and severity of the muscle degeneration. 13,67,68,82 It was shown conclusively how MRS and MRSI were used in numerous diseases to characterize an involvement of the muscular metabolism. Recent reviews offer more in-depth information.…”

Section: P Magnetic Resonance Spectroscopymentioning

confidence: 99%

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Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

Weber

Nagel

Kan

et al. 2020

Semin Musculoskelet Radiol

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The role of neuromuscular imaging in the diagnosis of inherited and acquired muscle diseases has gained clinical relevance. In particular, magnetic resonance imaging (MRI), especially whole-body applications, is increasingly being used for the diagnosis and monitoring of disease progression. In addition, they are considered as a powerful outcome measure in clinical trials. Because many muscle diseases have a distinct muscle involvement pattern, whole-body imaging can be of diagnostic value by identifying this pattern and thus narrowing the differential diagnosis and supporting the clinical diagnosis. In addition, more advanced MRI applications including non-proton MRI, diffusion tensor imaging, perfusion MRI, T2 mapping, and magnetic resonance spectroscopy provide deeper insights into muscle pathophysiology beyond the mere detection of fatty degeneration and/or muscle edema. In this review article, we present and discuss recent data on these quantitative MRI techniques in muscle diseases, with a particular focus on non-proton imaging techniques.

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Section: P Magnetic Resonance Spectroscopymentioning

confidence: 89%