MR1-restricted T cell clonotypes are associated with “resistance” to Mycobacterium tuberculosis infection

Cross, Deborah L.; Layton, Erik D.; Yu, Krystle K.Q.; Smith, Malisa T.; Aguilar, Melissa S.; Li, Shamin; Wilcox, Elise C.; Chapuis, Aude G.; Mayanja-Kizza, Harriet; Stein, Catherine M.; Boom, W. Henry; Hawn, Thomas R.; Bradley, Philip; Newell, Evan W.; Seshadri, Chetan

doi:10.1172/jci.insight.166505

JCI Insight

2024

DOI: 10.1172/jci.insight.166505

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MR1-restricted T cell clonotypes are associated with “resistance” to Mycobacterium tuberculosis infection

Deborah L. Cross,

Erik D. Layton,

Krystle K.Q. Yu

et al.

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2024

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Immune correlates of protection as a game changer in tuberculosis vaccine development

Wang,

Fan,

2024

npj Vaccines

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The absence of validated correlates of protection (CoPs) hampers the rational design and clinical development of new tuberculosis vaccines. In this review, we provide an overview of the potential CoPs in tuberculosis vaccine research. Major hindrances and potential opportunities are then discussed. Based on recent progress, it is reasonable to anticipate that success in the ongoing efforts to identify CoPs would be a game-changer in tuberculosis vaccine development.

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Immune correlates of protection as a game changer in tuberculosis vaccine development

Wang,

Fan,

2024

npj Vaccines

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MR1-restricted T cell clonotypes are associated with “resistance” to Mycobacterium tuberculosis infection

Cited by 1 publication

References 58 publications

Immune correlates of protection as a game changer in tuberculosis vaccine development

Immune correlates of protection as a game changer in tuberculosis vaccine development

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