MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study: Table 1

Akaishi, Tetsuya; Sato, Douglas Kazutoshi; Nakashima, Ichiro; Takeshita, Takayuki; Takahashi, Toshiyuki; Doi, Hiroshi; Kurosawa, Kazuhiro; Kaneko, Kimihiko; Kuroda, Hiroshi; Nishiyama, Shuhei; Misu, Tatsuro; Nakazawa, Toru; Fujihara, Kazuo; Akiyama, Masashi

doi:10.1136/jnnp-2014-310206

Cited by 131 publications

(127 citation statements)

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“…Some studies have found similar results for pRNFL and mGCIPL , where they are better preserved in patient with MOG-ON eyes than AQP4-ON eyes; however, the number of patients enrolled in this study was small 23. Another study yielded32 controversial results, where patients who were MOG-Ab-positive had more retinal atrophy than patients with AQP4-Ab-positive NMOSD.…”

Section: Discussionmentioning

confidence: 52%

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

et al. 2018

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Section: Discussionmentioning

confidence: 52%

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

et al. 2018

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“…All of the CSF samples were blindly analysed at Tohoku University to detect AQP4-Ab and MOG-Ab antibodies, using CBAs with human M23-AQP4 or full-length human MOG-transfected HEK293 live cells, as previously described 4. In those samples with confirmed CSF positivity for AQP4-Ab or MOG-Ab antibodies, MS and controls, astrocyte and myelin damage were evaluated by measuring CSF levels of GFAP and MBP, respectively, using commercially available ELISAs from Cosmic Corporation (Tokyo, Japan) and SPI bio (Montigny-le-Bretonneux, France) following manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies

Kaneko

Sato

Nakashima

et al. 2016

J Neurol Neurosurg Psychiatry

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“…Some previous studies, employing either structural or clinical assessment of visual function, suggested that MOG-IgG-positive patients have fewer attacks, better recovery from relapses, and less neuro-axonal retinal damage than AQP4-IgG-positive patients [4, 21, 22]. However, it is a potential drawback that observation periods were relatively short and sample sizes low in those studies.…”

Section: Introductionmentioning

confidence: 99%

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients

Pache

Zimmermann

Mikolajczak

et al. 2016

J Neuroinflammation

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BackgroundAntibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage in the retina of MOG-IgG-positive patients in comparison with AQP4-IgG-positive NMOSD patients.MethodsAfferent visual system damage following ON was bilaterally assessed in 16 MOG-IgG-positive patients with a history of ON and compared with that in 16 AQP4-IgG-positive NMOSD patients. In addition, 16 healthy controls matched for age, sex, and disease duration were analyzed. Study data included ON history, retinal optical coherence tomography, visual acuity, and visual evoked potentials.ResultsEight MOG-IgG-positive patients had a previous diagnosis of AQP4-IgG-negative NMOSD with ON and myelitis, and eight of (mainly recurrent) ON. Twenty-nine of the 32 eyes of the MOG-IgG-positive patients had been affected by at least one episode of ON. Peripapillary retinal nerve fiber layer thickness (pRNFL) and ganglion cell and inner plexiform layer volume (GCIP) were significantly reduced in ON eyes of MOG-IgG-positive patients (pRNFL = 59 ± 23 μm; GCIP = 1.50 ± 0.34 mm3) compared with healthy controls (pRNFL = 99 ± 6 μm, p < 0.001; GCIP = 1.97 ± 0.11 mm3, p < 0.001). Visual acuity was impaired in eyes after ON in MOG-IgG-positive patients (0.35 ± 0.88 logMAR). There were no significant differences in any structural or functional visual parameters between MOG-IgG-positive and AQP4-IgG-positive patients (pRNFL: 59 ± 21 μm; GCIP: 1.41 ± 0.27 mm3; Visual acuity = 0.72 ± 1.09 logMAR). Importantly, MOG-IgG-positive patients had a significantly higher annual ON relapse rate than AQP4-IgG-positive patients (median 0.69 vs. 0.29 attacks/year, p = 0.004), meaning that on average a single ON episode caused less damage in MOG-IgG-positive than in AQP4-IgG-positive patients. pRNFL and GCIP loss correlated with the number of ON episodes in MOG-IgG-positive patients (p < 0.001), but not in AQP4-IgG-positive patients.ConclusionsRetinal neuro-axonal damage and visual impairment after ON in MOG-IgG-positive patients are as severe as in AQP4-IgG-positive NMOSD patients. In MOG-IgG-positive patients, damage accrual may be driven by higher relapse rates, whereas AQP4-IgG-positive patients showed fewer but more severe episodes of ON. Given the marked damage in some of our MOG-IgG-positive patients, early diagnosis and timely initiation and close monitoring of immunosuppressive therapy are important.Electronic supplementary materialThe online version of this article (doi:10.1186/s12974-016-0720-6) contains supplementary material, which is available to authorized users.

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MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study: Table 1

Cited by 131 publications

References 5 publications

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients

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