MRI Findings in Deep and Generalized Morphea (Localized Scleroderma)

Horger, Marius; Fierlbeck, Gerhard; Kuemmerle‐Deschner, Jasmin; Tzaribachev, Nikolay; Wehrmann, Manfred; Claussen, Claus D.; Fritz, Jan

doi:10.2214/ajr.07.2163

Cited by 82 publications

(58 citation statements)

References 14 publications

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“…No laboratory markers have been found that aid long-term monitoring. Different imaging modalities have evaluated LS, including radiographs and CT scans, which show bone growth abnormalities, and MRI, which shows loss of subcutaneous tissue and deep tissue abnormalities [7,8]. Radiography and CT have the disadvantage of ionizing radiation, and MR use is limited by its expense and the need to sedate younger patients.…”

Section: Introductionmentioning

confidence: 99%

The use of doppler ultrasound to evaluate lesions of localized scleroderma

Liebling²

2009

Curr Rheumatol Rep

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Doppler ultrasound shows great promise for the evaluation of localized scleroderma (LS). Disease-related structural changes, such as tissue thickening, atrophy, and architectural alterations, can be readily detected using ultrasound. High spatial resolution enables monitoring of changes in tissue thickness over the course of disease and treatment. Doppler ultrasound may also aid assessment of disease activity. Both abnormal tissue echogenicity and vascularity levels can represent disease activity in some patients. Because tissue thickness, echogenicity, and vascularity vary with body site and age, accurate ultrasound evaluation of the LS lesion requires comparison to a control site, ideally the contralateral side. Evaluation of deeper tissues is important, as disease involvement may reside primarily below the dermis. Further study is needed to determine the validity, sensitivity, and reliability of ultrasound for LS.

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Section: Introductionmentioning

confidence: 99%

The use of doppler ultrasound to evaluate lesions of localized scleroderma

Liebling²

2009

Curr Rheumatol Rep

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“…• Magnetic resonance imaging (MRI) and computed tomography (CT) are two imaging methods used in more severe cases of LoSc involving the skin, subcutaneous tissue, muscles, fasciae and bones [38]. On account of frequent CNS and eye involvement patients with localized scleroderma en coup de sabre and progressive facial hemiatrophy require individual assessment to determine whether MRI and CT are warranted [2,3].…”

Section: Metody Oceny Aktywności Lub Nasilenia Choroby I Uszkodzenia mentioning

confidence: 99%

“…• Rezonans magnetyczny i tomografia komputerowa (magnetic resonance imaging -MRI, computed tomography -CT) -metody obrazowania stosowane w cięższych przypadkach LoSc, które przebiegają z zajęciem skóry, tkanki podskórnej, mięśni, powięzi i kości [38]. Pacjenci z twardziną typu cięcia szablą oraz z postępującym zanikiem połowiczym twarzy wymagają indywidualnej oceny pod kątem wykonania powyższych badań ze względu na częste zajęcie OUN i narzą-du wzroku [2,3].…”

Section: Metody Oceny Aktywności Lub Nasilenia Choroby I Uszkodzenia unclassified

Localized scleroderma – classification and tools used for the evaluation of tissue damage and disease activity/severity

Wolska-Gawron¹,

Krasowska²

2017

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Localized scleroderma is a rare autoimmune disorder affecting the dermis, subcutaneous tissue and deeper structures. The course of localized scleroderma includes three stages: early inflammation, progressive sclerosis and atrophy. The active stage of the disease is characterized by erythema ('lilac ring'), skin induration, and appearance of new or expansion of pre-existing skin lesions during the preceding month. The most recent localized scleroderma classification recognizes five types of the disease: localized, generalized, linear, deep and mixed. Various methods have been proposed for the evaluation of disease activity or severity and tissue damage, including ultrasonography, thermography, durometry, computed tomography and magnetic resonance imaging. However, all of them have their limitations, as they only make it possible to assess one component of the disease: activity or severity or tissue damage. The LS Cutaneous Assessment Tool (LoSCAT) questionnaire is a promising method of patient evaluation because of its availability, repeatability of results and sensitivity to changes resulting from treatment. STRESZCZENIETwardzina ograniczona jest rzadką chorobą autoimmunologiczną, która przebiega z zajęciem skóry, tkanki podskórnej i tkanek głębiej położonych. Choroba klinicznie ma trzy fazy: wczesną zapalną, postępującego stwardnienia i zanikową (atroficzną). Wykładnikami aktywnego procesu chorobowego są: rumień (lilac ring), stwardnienie skóry, pojawianie się nowych wykwitów skórnych lub powiększenie wcześniej istniejących zmian w ciągu ostatniego miesiąca. Najnowsza klasyfikacja wyróżnia pięć typów twardziny ograniczonej: ograniczona, uogólniona, linijna, głęboka i mieszana. Zaproponowano wiele metod oceny aktywności lub nasilenia choroby oraz uszkodzenia tkanek, takich jak ultrasonografia, termografia, durometria, tomografia komputerowa czy rezonans magnetyczny. Ograniczenia powyż-szych badań wynikają z możliwości oceny tylko jednego wykładnika -aktywności lub nasilenia choroby albo uszkodzenia tkanek. Przedstawiona metoda ewaluacji pacjentów oparta na zastosowaniu kwestionariusza do oceny aktywności i nasilenia choroby (LoSCAT) jest godna uwagi ze względu na dostępność narzędzia, powtarzalność wyników, a także czułość formularza na zmiany wynikające z zastosowanego leczenia.

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“…In the early inflammatory stages of the disease, MRI shows thickening of the dermis and infiltration of the subcutaneous tissue with an increase in signal intensity on shorttau inversion recovery images and contrast-enhanced T1-weighted images, and hypointense signal on unenhanced T1-weighted images. Involvement of fascia and musculature beneath the skin is reflected by similar signal intensities [64]. Neuroimaging is also indicated for patients with the linear scleroderma en coup de sabre variety.…”

Section: Mrimentioning

confidence: 99%

Diagnosis and treatment of systemic and localized scleroderma

Khanna¹

2011

Expert Review of Dermatology

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MRI Findings in Deep and Generalized Morphea (Localized Scleroderma)

Cited by 82 publications

References 14 publications

The use of doppler ultrasound to evaluate lesions of localized scleroderma

The use of doppler ultrasound to evaluate lesions of localized scleroderma

Localized scleroderma – classification and tools used for the evaluation of tissue damage and disease activity/severity

Diagnosis and treatment of systemic and localized scleroderma

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