MRI findings in medial temporal lobe structures in schizophrenia

Becker, Thomas; Elmer, K.; Mechela, B.; Schneider, Frank; Taubert, S.; Schroth, Gerhard; Grodd, Wolfgang; Bartels, Matthias; Beckmann, H.

doi:10.1016/0924-977x(90)90018-6

Cited by 33 publications

(13 citation statements)

References 9 publications

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“…Becker et al, 1990;Bogerts et al, 1990;Dauphinais et al, 1990;Degreef et al, 1990;DeLisi et al, 1991;Johnstone et al, 1989;Kawasaki et al, 1993;Niemann et al, 2000;Roy et al, 1998;Shenton et al, 1992). These MRI findings are also consistent with several post-mortem findings which have reported both reduced volume in the amygdala-hippocampal complex and increased temporal horn volume (e.g.…”

Section: Lateral Ventriclessupporting

confidence: 78%

“…Becker et al, 1990Becker et al, , 1996Bogerts et al, 1990Bogerts et al, , 1993bBreier et al, 1992;Chua and McKenna, 1995;DeLisi et al, 1988DeLisi et al, , 1991Hirayasu et al, 1998;Kawasaki et al, 1993;Lawrie et al, 1999;Shenton et al, 1992). There has nonetheless generally been an attempt made to delineate an anterior portion which is primarily amygdala, and a posterior portion which is primarily hippocampus.…”

Section: Temporal Lobe Findingsmentioning

confidence: 99%

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A review of MRI findings in schizophrenia

Shenton

Dickey

Frumin

et al. 2001

Schizophrenia Research

2,145

121

1,332

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After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin,E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the ' schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G. K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia.The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier postmortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe ab...

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Section: Lateral Ventriclessupporting

confidence: 78%

Section: Temporal Lobe Findingsmentioning

confidence: 99%

A review of MRI findings in schizophrenia

Shenton

Dickey

Frumin

et al. 2001

Schizophrenia Research

2,145

121

1,332

View full text Add to dashboard Cite

show abstract

“…The Neuroscientist 18 (2) Study or Subgroup Altshuler et al, 1998Baiano et al, 2008Becker et al, 1990Breier et al, 1992Chakos et al, 2005Chakos et al, 2005c Ebdrup et al, 2010Exner et al, 2008Frazier et al, 2008Fukuzako et al, 1996Fukuzako et al, 1997Gur et al, 2000Kuroki et al, 2006Levitt et al, 2001Marsh et al, 1997Matsumoto et al, 2001Meisenzahl et al, 2009Meisenzahl et al, 2009c Niemann et al, 2000Rajarethinam et al, 2001Rametti et al, 2007Razi et al, 1999Razi et al, 1999c Rupp et al, 2005Rusch et al, 2008Sachdev et al, 2000Sallet et al, 2003Sanfilipo et al, 2000Sim et al, 2006Smith et al, 2003Spoletini et al, 2011c Strasser et al, 2005Sumich et al, 2002 Suzuki et al, 2005 (b) Swayze et al, 1992Szendi et al, 2006Szeszko et al, 2003Takahashi et al, 2006Tanskanen et al, 2005Velakoulis et al, 1999Velakoulis et al, 1999c Verma et al, 2009Weiss et al, 2005…”

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confidence: 97%

Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia

2011

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Several magnetic resonance imaging studies have reported hippocampal volume reduction in patients with schizophrenia, but other studies have reported contrasting results. In this review and meta-analysis, the authors aim to clarify whether a reduction in hippocampal volume characterizes patients with schizophrenia by considering illness phase (chronic and first episode) and hippocampus side separately. They made a detailed literature search for studies reporting physical volumetric hippocampal measures of patients with schizophrenia and healthy control (HC) participants and found 44 studies that were eligible for meta-analysis. Individual meta-analyses were also performed on 13 studies of first-episode patients and on 22 studies of chronic patients. The authors also detected any different findings when only males or both males and females were considered. Finally, additional meta-analyses and analyses of variance investigated the role of the factors "illness phase" and "side" on hippocampal volume reduction. Overall, the patient group showed significant bilateral hippocampal volume reduction compared with HC. Interestingly, first-episode and chronic patients showed same-size hippocampal volume reduction. Moreover, the left hippocampus was smaller than the right hippocampus in patients and HC. This review and meta-analysis raises the question about whether hippocampal volume reduction in schizophrenia is of neurodevelopmental origin. Future studies should specifically investigate this issue.

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“…2000;57:769-775 T EMPORAL LOBE structures and circuitry modulate cognition and emotion, prompting their neuroanatomic examination in schizophrenia. Investigations with magnetic resonance imaging (MRI) have evaluated lobar volumes [1][2][3][4][5] and specific subregions [6][7][8][9][10][11][12][13][14][15] implicated in neurobehavioral domains aberrant in schizophrenia, such as memory. Regional volumes have also been linked to clinical features, including thought disorder and auditory hallucinations.…”

mentioning

confidence: 99%

“…[16][17][18] Studies have reported volume reduction in the global temporal lobe, 1 gray matter (GM), but not white matter (WM), 2,11 with lateralization to the left hemisphere. 3 Regional analysis revealed decreased vol-ume in temporolimbic structures including the hippocampus, 6,7,9,11,12,[19][20][21][22] parahippocampal gyrus, 7,23 and amygdala. 19,20 However, some studies did not find differences in these regions.…”

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confidence: 99%