MRI In rectal cancer: Correlations between MRI features and molecular markers Ki‐67, HIF‐1α, and VEGF

Meng, Xiangjiao; Li, Huijuan; Kong, Lingling; Zhao, Xianguang; Huang, Zhaoqin; Zhao, Haitao; Zhu, Wei; Li, Xin; J, Yu; Xing, Ligang

doi:10.1002/jmri.25195

Cited by 36 publications

(31 citation statements)

References 35 publications

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“…There is increasing evidence that ADC reflects KI67 index in several tumors [ 5 ]. In rectal cancer, a correlation coefficient of r=-0.42 was identified in a recent meta-analysis [ 5 ], with a range from r=-0.30 to −0.49 indicating only a moderate correlation in this tumor entity [ 4 , 18 , 19 ]. However, no histogram analysis was used to identify further associations with Ki67 index in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, only few studies investigated possible associations between ADC values and histopathology findings like cellularity, KI 67 and VEGF [ 4 , 6 , 18 , 19 ], but none of them used the histogram approach. Presumably, ADC values might not only be able to reflect cellularity in rectal cancer but also other histopathological markers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study

Meyer

Höhn

2018

Oncotarget

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Functional imaging modalities like Diffusion-weighted imaging are increasingly used to predict tumor behavior like cellularity and vascularity in different tumors. Histogram analysis is an emergent imaging analysis, in which every voxel is used to obtain a histogram and therefore statistically information about tumors can be provided. The purpose of this study was to elucidate possible associations between ADC histogram parameters and several immunhistochemical features in rectal cancer. Overall, 11 patients with histologically proven rectal cancer were included into the study. There were 2 (18.18%) females and 9 males with a mean age of 67.1 years. KI 67-index, expression of p53, EGFR, VEGF, and Hif1-alpha were semiautomatically estimated. The tumors were divided into PD1-positive and PD1-negative lesions. ADC histogram analysis was performed as a whole lesion measurement using an in-house matlab application.Spearman's correlation analysis revealed a strong correlation between EGFR expression and ADCmax (p=0.72, P=0.02). None of the vascular parameters (VEGF, Hif1-alpha) correlated with ADC parameters. Kurtosis and skewness correlated inversely with p53 expression (p=-0.64, P=0.03 and p=-0.81, P=0.002, respectively). ADCmedian and ADCmode correlated with Ki67 (p=-0.62, P=0.04 and p=-0.65, P=0.03, respectively). PD1-positive tumors showed statistically significant lower ADCmax values in comparison to PD1-negative tumors, 1.93 ± 0.36 vs 2.32 ± 0.47×10−3mm2/s, p=0.04.Several associations were identified between histogram parameter derived from ADC maps and EGFR, KI 67 and p53 expression in rectal cancer. Furthermore, ADCmax was different between PD1 positive and PD1 negative tumors indicating an important role of ADC parameters for possible future treatment prediction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study

Meyer

Höhn

2018

Oncotarget

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“…Accordingly, these represent two facets of tumour biology, and both parameters are used for predicting prognosis. 4,5,9,34 Curvo-Semedo et al 5 demonstrated that lower ADC values were associated with a more aggressive tumour profile in 50 rectal cancers. In our experience, mEMVI and low ADC min values were significantly correlated with synchronous M stage in NMC.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Diffusion-weighted imaging (DWI) maps the diffusion of water molecules, with diffusion in malignant tissues having high signal intensity and a low apparent diffusion coefficient (ADC) and it is considered as a potential predictive value of aggressiveness. 4,5 Fluorine-18 fludeoxyglucose (FDG) positron emission tomography (PET)-CT imaging is based on the theory that enhanced glucose metabolism represents a major and characteristic metabolic change in tumour cells. According to this theory, tumour cells demonstrate increased FDG uptake, which is related to the proliferative activity and aggressiveness of the tumour.…”

Section: Introductionmentioning

confidence: 99%

The potential predictive value of MRI and PET-CT in mucinous and nonmucinous rectal cancer to identify patients at high risk of metastatic disease

Barbaro¹,

Leccisotti²,

Vecchio³

et al. 2017

BJR

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“…After thorough review 14 articles were suitable for the present meta-analysis [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used for the research [31].…”

Section: Data Acquisitionmentioning

confidence: 99%

Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors—A Systematic Review and Meta-Analysis

Meyer¹,

Wienke

2019

Diagnostics

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To date, only a few studies have investigated relationships between Diffusion-weighted imaging (DWI) and Vascular endothelial growth factor (VEGF) expression in tumors. The reported results are contradictory. The aim of the present analysis was to review the published results and to perform a meta-analysis regarding associations between apparent diffusion coefficients (ADC) derived from DWI and VEGF expression. MEDLINE library was screened for relationships between ADC and VEGF expression up to January 2019. Overall, 14 studies with 578 patients were identified. In 10 studies (71.4%) 3 T scanners were used and in four studies (28.6%) 1.5 T scanners. Furthermore, seven studies (50%) had a prospective design and seven studies (50%) had a retrospective design. Most frequently, prostate cancer, followed by rectal cancer, cervical cancer and esophageal cancer were identified. The pooled correlation coefficient of all tumors was r = −0.02 [95% CI −0.26–0.21]. ADC values derived from routinely acquired DWI do not correlate with VEGF expression in various tumors. Therefore, DWI is not sensitive enough to reflect angiogenesis-related microstructure of tumors.

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MRI In rectal cancer: Correlations between MRI features and molecular markers Ki‐67, HIF‐1α, and VEGF

Abstract: Our results suggest that the ADC values on DW-MRI may be used as a measurement of cell proliferation and hypoxia in RC. J. Magn. Reson. Imaging 2016;44:594-600.

Cited by 36 publications

References 35 publications

Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study

Histogram analysis of ADC in rectal cancer: associations with different histopathological findings including expression of EGFR, Hif1-alpha, VEGF, p53, PD1, and KI 67. A preliminary study

The potential predictive value of MRI and PET-CT in mucinous and nonmucinous rectal cancer to identify patients at high risk of metastatic disease

Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors—A Systematic Review and Meta-Analysis

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