mRNA-based vaccines – global approach, challenges, and could be a promising wayout for future pandemics

Makhijani, Shivani; Elossaily, Gehan M.; Rojekar, Satish; Ingle, Rahul G.

doi:10.1080/10837450.2024.2361656

Cited by 4 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, solid microneedles alone cannot distribute or facilitate the passage of drugs. [38,39].Then, medications were injected or applied directly to the skin region punctured by microneedles in square patches. Scientists described a method involving the construction of a device utilizing a nanoscale zinc oxide pyramidal rod array.…”

Section: Solid Microneedlesmentioning

confidence: 99%

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Rojekar,

Parit,

Gholap

et al. 2024

Preprint

View full text Add to dashboard Cite

Microneedle technology is a novel platform technology that revolutionizes ocular drug delivery and addresses critical challenges in the treatment of ocular diseases. Routine treatment methods, such as eye drops and intravitreal injections, suffer from low bioavailability and poor patient compliance. So, novel advanced platform technologies are required to overcome these challenges. Microneedle is a minimally invasive and promising alternative technique that helps precisely control drug delivery to targeted tissues and organs. This review investigates the potential impact of microneedle technology for eye care, underscoring recent advancements, underlying mechanisms, and emerging preclinical and clinical uses. Different types of microneedles, including solid, coated, dissolvable, and hollow, have demonstrated their potential and capability to bypass several barriers in the cornea and sclera. This ensures effective drug penetration and delivery. The current innovations in material science and fabrication methods have enhanced the safety and efficacy of microneedles, reducing discomfort and the chances of infections. These microneedle technologies offer sustained and controlled drug delivery, which could improve therapeutic outcomes for various disease conditions like age-related macular degeneration, glaucoma, diabetic neuropathy, etc. In the current review, recent preclinical and clinical studies emphasize microneedle-based ocular drug delivery's feasibility and potential benefits. These include improved pharmacokinetics, reduced dosing frequency, enhanced patient adherence, and, most importantly, microneedles offer versatile platforms for delivering a wide range of small and large molecules and gene therapies. Despite the exciting progress, obstacles such as regulatory barriers, scalability, and long-term biocompatibility persist. It will be essential to tackle these challenges through interdisciplinary research and partnerships to integrate microneedle technology into standard clinical use effectively. Ultimately, microneedle drug delivery offers a revolutionary method that has the potential to significantly enhance the treatment and results of ocular diseases, marking the dawn of a new era in eye care.

show abstract

Section: Solid Microneedlesmentioning

confidence: 99%

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Rojekar,

Parit,

Gholap

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Design and performance analysis of portable solar powered cooler for vaccine storage

Marwa,

Kivevele,

Kichonge

et al. 2024

Energy Science & Engineering

View full text Add to dashboard Cite

The efficacy of vaccine storage is significantly impacted by temperature fluctuations within the cooler, often exacerbated by using phase change materials in existing cooler designs for remote areas. These materials can undergo uneven melting and phase separation, leading to temperature instability and vaccine potency loss. In response to this challenge, the present study introduces a novel design of a portable, locally‐made solar‐powered cooler optimized for longer storage periods. The cooler's performance in terms of temperature distribution, airflow dynamics, and the coefficient of performance (COP) is meticulously examined through computational fluid dynamics (CFD) simulations. The simulated results were validated using experimental data from the open literature, ensuring accuracy and reliability. The findings indicate that the developed cooler achieves significant improvements over traditional models. For instance, the current model reaches a temperature of +12°C in just 84 min, compared to 208 min, as reported in the literature results. Moreover, the current model reaches a temperature of −12°C in 195 min and it has energy efficient with a COP of 4.5. Statistical analysis further confirms the reliability of the simulation results, with root mean square and mean absolute percentage errors of 6.587 and 24.2%, respectively. Additionally, a comparative study of five insulative materials highlights polyurethane (Po) as the top performer, with a heat transfer performance of 14.3%, followed by feather fiber (Fe) (18.7%), fly ash (Fl) (19.8%), fiberglass (Fi) (21.9%), and coconut fiber (Co) (25.9%). Notably, net present value (NPV) of $689.336 and $448.01 was obtained for economic analysis of the current model over the existing model, showing the feasibility of the study. Hence, the cooler's effectiveness in storing vaccines in isolated regions exceeds that of conventional models, providing a hopeful solution to tackle vital challenges in vaccine distribution and preservation.

show abstract